- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02012855
Effect of Different Types of Carbohydrates Consumed After Exercise on Blood Fat Levels
May 2, 2017 updated by: Phil Chilibeck, University of Saskatchewan
Effect of Exercise and Glycemic Index of Carbohydrate Feeding on Postprandial Lipid Metabolism
The increase in fat (i.e.
triglyceride) in the blood after a meal is a well-established risk factor for heart disease (Nordestgaard et al. 2007).
Endurance exercise is beneficial for improving the blood lipid response to a subsequent meal; that is, the appearance of fat (triglyceride) in the blood is less after a meal if endurance exercise was performed shortly before (i.e.
within half a day) of the meal (Petit et al. 2003).
This benefit of exercise is unfortunately negated if the after-exercise food choice to replace the calories expended during exercise is one containing high glycemic index carbohydrates.
For example, if a high glycemic index carbohydrate is consumed after an evening exercise session, the exercise no longer has an effect of lowering triglyceride in the blood after a meal consumed the next morning (Harrison et al. 2009; Burton et al. 2008).
Very rarely do people perform an exercise session and then fast until their next meal hours later.
The more common practice is to consume food immediately after the exercise to enhance recovery and because hunger is stimulated with exercise.
Consuming carbohydrate with a low glycemic index has been shown to reduce the level of fat in the blood following a subsequent meal (Gruendel et al. 2007).
To date, no studies have examined the effects of consuming a low-glycemic index meal after exercise on the blood fat response to a subsequent meal.
The specific objective of our research is to determine the effect of consuming low glycemic index lentils after an endurance exercise session on the blood fat (triglyceride) response to a subsequent meal.
Twenty-five overweight or obese men will have their blood triglycerides measured four times over six hours after a high-fat morning meal following four different conditions, in a randomized, counterbalanced, cross-over design (i.e. the 25 subjects will each participate in all four conditions, where the order of conditions for each person is randomized): 1) After exercise (90 minutes of moderate intensity walking) is performed the evening before, followed by caloric replacement with a high-glycemic index meal (i.e.
white bread and instant mashed potatoes); 2) After the same exercise is performed the evening before, followed by caloric replacement with a lentil-based meal; 3) After the same exercise is performed the evening before, followed by fasting; 4) After a no exercise/ no meal condition (i.e.
control condition).
In addition to measuring blood triglycerides we will measure blood insulin, free fatty acid, high density lipoproteins, low density lipoproteins, and glucose levels as these are also related to cardiovascular disease risk and may be altered with exercise and lentil consumption.
We will also measure the muscle's ability to burn fat (i.e.
fat oxidation) by assessing respiratory gases (oxygen consumption and carbon dioxide output) after the high-fat meal because we expect exercise and lentils to increase fat oxidation.
Our expected results are that consuming lentils after endurance exercise will lower the blood triglyceride response to a subsequent meal compared to exercise alone or when high-glycemic index carbohydrates are consumed after the exercise.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
23
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Saskatchewan
-
Saskatoon, Saskatchewan, Canada, S7N 5B2
- University of Saskatchewan
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 44 years (Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Body mass index of 25 or greater
- 18-44 years of age
Exclusion Criteria:
- diabetics
- smokers
- those taking medications for cholesterol or glucose
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Exercise only
90 minutes of exercise
|
|
Experimental: Exercise and high glycemic index meal
90 minutes of exercise followed by a high glycemic index meal matched for calories expended during the exercise
|
|
Experimental: Exercise and low glycemic index meal
90 minutes of exercise followed by a low glycemic index meal matched for calories expended during the exercise
|
|
No Intervention: No exercise and no meal
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Change in blood triglycerides
Time Frame: Change from baseline at 6 hours
|
Change from baseline at 6 hours
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Change in blood glucose
Time Frame: Change from baseline at 6 hours
|
Change from baseline at 6 hours
|
Change in fat oxidation
Time Frame: Change from baseline at 6 hours
|
Change from baseline at 6 hours
|
Change in low density lipoproteins
Time Frame: Change from baseline at 6 hours
|
Change from baseline at 6 hours
|
Change in high density lipoproteins
Time Frame: Change from baseline at 6 hours
|
Change from baseline at 6 hours
|
Change in total cholesterol
Time Frame: Change from baseline at 6 hours
|
Change from baseline at 6 hours
|
Change in insulin level
Time Frame: Change from baseline at 6 hours
|
Change from baseline at 6 hours
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
August 1, 2013
Primary Completion (Actual)
August 1, 2015
Study Completion (Actual)
August 1, 2015
Study Registration Dates
First Submitted
August 15, 2013
First Submitted That Met QC Criteria
December 10, 2013
First Posted (Estimate)
December 16, 2013
Study Record Updates
Last Update Posted (Actual)
May 5, 2017
Last Update Submitted That Met QC Criteria
May 2, 2017
Last Verified
May 1, 2017
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 000041
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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