- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02025309
Intraoperative Methylprednisolone and Sugammadex
Does Intraoperatively Administered Methylprednisolone Prolong the Neuromuscular Blocade Reversal Effect of Sugammadex?
Sugammadex, a modified γ-cyclodextrin is a selective relaxant-binding agent that reverses the effects of steroidal neuromuscular blocking agents, rocuronium and vecuronium. It shows its activity by encapsulating these. Likewise, some other steroid hormones and drugs like flucloxacillin, toremifene, fusidic acid can also be effected. Thus, assuming that methylprednisolone would also be encapsulated by sugammadex and decrease its efficiency, in this study we aimed to compare the recovery times from recuronium-induced muscle relaxation after reversal with sugammadex between patients who receive intraoperative methylprednisolone or not.
After institutional review board (IRB) approval and informed consent, 100 patients will be enrolled in this prospective, single center, controlled study. Anaesthesia will be induced with propofol (3mg/kg) and rocuronium (0.6 mg/kg), followed by sevoflurane maintenance. Patients will be divided randomly into two groups methylprednisolone administered group and control group respectively). Neuromuscular blockade will be monitored using calibrated acceleromyography train-of-four (TOF WATCH SX Organon Ltd, Dublin, Ireland). Once rocuronium-induced neuromuscular blockade recovers spontaneously to TOF-count-two, all patients will receive 2.0 mg/kg of sugammadex. Neuromuscular monitoring will be continued until recovery of the TOF ratio to 0.9 at the ulnar nerve. The time to recovery of TOF to 0.9 will be compared in both groups. The statistical analyses will be performed using Student T Test and Mann-Whitney U test.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Phase
- Phase 4
Contacts and Locations
Study Locations
-
-
-
Ankara, Turkey, 06700
- Ankara University Faculty of Medicine, Ibni Sina Hospital OR
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- patient operated under general anesthesia and endothracheal intubation.
- 18-65 years old
- ASA II
Exclusion Criteria:
- Neuromuscular desease
- Renal desease
- Liver failure
- Hypersensitivity to the medications used in the study.
- Being on steroid medication
- Pregnanacy, Lactation
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Screening
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Group Methylprednisolone
Patient in this group received general anaesthesia for surgical procedures.
During the anesthesia management methylprednisolone was administered intravenously (1mg/kg) to the patients in this group.
Also neuromuscular monitorisation was performed to assess the train of four ratio at the end of the procedure, after the reversal of neuromuscular block.
All patients were followed during the recovery period from general anaesthesia and the time needed to regain a full neuromuscular recovery was noted.
For that, the train of four ratio was followed up and the ratio of 0.9 was recorded.
|
Other Names:
|
Placebo Comparator: Group Control
Patients who received general anaesthesia and endothracheal entubation but who did not recieved methyprednisone during general anaesthesia were enrolled in the study as control group.
Neuromuscular monitorisation was performed to assess the train of four ratio at the end of the procedure, after the reversal of neuromuscular block.
All patients were followed during the recovery period from general anaesthesia and the time needed to regain a full neuromuscular recovery was noted.
For that, the train of four ratio was followed up and the ratio of 0.9 was recorded.
|
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Train of four ratio 0.9
Time Frame: During the procedure period.
|
At the end of the procedure, train of four (TOF) monitorisation was continued and once rocuronium-induced neuromuscular blockade recovered spontaneously to TOF-count-two, all patients received 2.0 mg/kg of sugammadex.
Then, neuromuscular monitoring was continued until recovery of the TOF ratio to 0.9 at the ulnar nerve.
The time needed for the recovery of TOF to 0.9 was noted.
|
During the procedure period.
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Merve Hayriye Kocaoglu, MD, Ankara University Faculty of Medicine
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- 16-627-13
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Neuromuscular Monitoring
-
Fondazione IRCCS Istituto Nazionale dei Tumori,...CompletedNeuromuscular Blockade | Neuromuscular MonitoringItaly
-
Universitair Ziekenhuis BrusselUnknownNeuromuscular Blockade | Neuromuscular MonitoringBelgium
-
University Hospital, CaenCompletedNeuromuscular Monitoring
-
Erasme University HospitalRecruitingNeuromuscular Monitoring | Neuromuscular Blocking AgentsBelgium
-
Onze Lieve Vrouw HospitalMayo ClinicTerminated
-
Tianjin Medical University General HospitalCompletedNeuromuscular Monitoring
-
Hospital Universitario La FeCompletedNeuromuscular Blockade MonitoringSpain
-
University of DebrecenCompletedNeuromuscular Monitoring | ElectromyographyHungary
-
Central Hospital, Nancy, FranceUnknownNeuromuscular Monitoring | CurarisationFrance
-
Erasme University HospitalRecruiting
Clinical Trials on Neuromuscular monitorisation
-
Iuliu Hatieganu University of Medicine and PharmacyUnknownSepsis | Septic Shock | Hemodynamic InstabilityRomania
-
Antalya Training and Research HospitalCompleted
-
Universidad San JorgeCompletedMuscle Tone AbnormalitiesSpain
-
Ajou University School of MedicineCompletedPneumoperitoneumKorea, Republic of
-
Brooks RehabilitationTerminatedBlepharoptosis | LagophthalmosUnited States
-
University Hospital, BrestRecruitingAsthma | Chronic Obstructive Pulmonary Disease Overlap SyndromeFrance
-
Riphah International UniversityCompleted
-
University of Texas Southwestern Medical CenterMerck Sharp & Dohme LLCRecruiting
-
Hacettepe UniversityNot yet recruiting
-
Konkuk University Medical CenterCompletedHip FracturesKorea, Republic of