- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02078037
Systemic Normothermia in Intracerebral Hemorrhage (ICH) (SNICH)
January 6, 2017 updated by: The Cleveland Clinic
Patients with a supratentorial intracerebral hemorrhage will be randomly assigned to either the experimental group which will keep them at a normal body temperature or the standard of care group.
The investigators propose to test the hypothesis that prophylactic forced normothermia in patients with ICH leads to less systemic inflammation and decreased perihematomal edema.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
This is a randomized device efficacy trial.
Patients with a supratentorial intracerebral hemorrhage (ICH) admitted to the Cleveland Clinic Neurointensive Care Unit within 1 day of symptom onset and who have not experienced episodes of temperature elevation will be enrolled after consent.
Patients randomized to the experimental arm, will have Artic Sun cooling pads applied to the torso and thighs for five days.
The Arctic Sun device will keep the body temperature at the normal range of 35.5 - 37.5 degrees Celsius.
Patients randomized to the active comparator arm will receive a standard of care treatment at the discretion of the treating physician.
Patients will have hourly measurement of blood pressure, heart rate, respiratory rate, urine output, temperature (from the urinary catheter) shivering scale, and nursing neurological assessment.
Glasgow coma scale, NIH Stroke Scale Score (NIHSS), telemetry monitoring and labs will also be performed daily.
The investigators will also collect demographic information about the patients (i.e.
age, gender, medical risk factors) and information regarding their current disease process.
Study Type
Interventional
Enrollment (Actual)
9
Phase
- Early Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Ohio
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Cleveland, Ohio, United States, 44195
- Cleveland Clinic
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
16 years to 83 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Patients with spontaneous supratentorial ICH >20 cc
- Age 18 to 85 years of age
- Consent from the patient or surrogate decision maker
- Within 24 hours of onset of ictus
Exclusion Criteria:
- Hemorrhage secondary to trauma, Arterio-venous malformation (AVM), aneurysm or Arterio-venous dural fistula
- Moribund state and deemed unlikely to survive until study completion (5 days)
- Patients with a don-not-resuscitate (DNR) order
- Known infection at the time of admission (elevated white blood cell count (WBC) with identified infection source).
- Evidence of a blood dyscrasia
- Pregnancy
- Renal failure (CCR < 50 ml/min)
- Contraindications for a brain MRI scan
- Infratentorial ICH
- Warfarin-induced intracerebral hemorrhages NOT corrected to International Normalized Ratio (INR) < 1.4 within 24 hours
- Episode of fever > 38.5 degrees Celsius prior to enrollment
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Arctic Sun cooling device
The Arctic Sun device pads will be placed on the patient as per manufacturer's instructions.
Patients, who cannot tolerate placement of all the pads for any given reason, will still be included in the study if they can maintain normothermia (normal body temperature).
The total normothermia time for the study is five days.
After 5 days, the attending physician will make clinical decisions based on the patient needs.The temperature goal for this study is 36.5 degree Celsius, but normothermia for the purpose of this study will be defined as a temperature of 35.5 - 37.5 degree Celsius.
A thermometer mounted urinary catheter will be used for temperature monitoring and feedback to the Arctic Sun.
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The Arctic Sun® 5000 Temperature management systems (Bard Medical), a non- invasive, surface cooling technology that allows rapid and precise manipulation of core body temperature will be employed to maintain normothermia (normal temperature) in patients with ICH randomized to the treatment group.
Other Names:
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Active Comparator: Standard of Care
Patient will be given standard fever management (acetaminophen + cooling blanket at the discretion of the treating physician) initiated at a temperature of 38.5 degrees Celsius
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Patient will be given standard fever management (acetaminophen + cooling blanket at the discretion of the treating physician)
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
MRI measurement of relative perihematomal edema (% change of perihematomal edema)
Time Frame: First 5 days of hospital course
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Percent relative perihematomal edema growth between the initial MRI and the 5 day MRI
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First 5 days of hospital course
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Structured telephone interview of functional and cognitive outcome
Time Frame: 3 months and 1 year
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Functional and cognitive outcomes measured by structured phone assessment.
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3 months and 1 year
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Serum cytokine measurement with inflammatory cytokine protein array
Time Frame: 5 days
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Cytokine markers of inflammation tested daily over the first 5 days.
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5 days
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Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Serum cytokine measurement with inflammatory cytokine protein array in control ICH patients
Time Frame: 5 days
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Cytokine markers of inflammation tested daily over the first five days of the study in control ICH patients to determine the natural inflammation history of ICH.
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5 days
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Diagnosis of Pneumonia/Sepsis/Adult Respiratory Distress Syndrome (ARDS)
Time Frame: First 10 days of hospital stay
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Berlin classification for mild adult respiratory distress syndrome (previously ALI) and adult respiratory distress syndrome (ARDS).
Centers for Disease Control and Prevention (CDC) definitions for pneumonia and sepsis.
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First 10 days of hospital stay
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Javier J Provencio, MD, The Cleveland Clinic
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
March 1, 2014
Primary Completion (Actual)
April 1, 2016
Study Completion (Actual)
April 1, 2016
Study Registration Dates
First Submitted
February 21, 2014
First Submitted That Met QC Criteria
March 3, 2014
First Posted (Estimate)
March 5, 2014
Study Record Updates
Last Update Posted (Estimate)
January 10, 2017
Last Update Submitted That Met QC Criteria
January 6, 2017
Last Verified
January 1, 2017
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 13-1407
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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