Clinical Trial for PB-119 in Healthy Subjects (Phase I)

Safety, Tolerability and Pharmacokinetics of Single Dose of PB-119 in Healthy Volunteers

GLP-1 analogues have been widely used because of their unique advantages (no risk of hypoglycemia) due to their glucose dependent mechanism. Due to the short half-life of peptide in plasma, peptides have to be administered frequently (i.e. BID for Byetta, with Exenatide as API).To improve the patients compliance and reduce potential adverse events associated with GLP-1 analogues, a long acting GLP-1 analogue (PB-119), which may be administered once weekly, was developed by PegBio Inc. In order to provide rational for dosage range to be studied in Phase Ib, the safety profile, tolerance, and pharmacokinetic behavior of PB-119 in healthy subjects will be studied in this randomized, controlled dose escalating trial.

Study Overview

• Status: Completed
• Conditions: Type II Diabetes
• Intervention / Treatment: Drug: PB-119

• Study Type: Interventional
• Enrollment (Actual): 70
• Phase: Phase 1

Contacts and Locations

Study Locations

• China
  • Beijing
    • Beijing, Beijing, China, 100000
      • Peking University First Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 45 years (ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Male or female volunteers, ages: between 18-45;
• Body weight： female >= 45kg, male >=50kg, BMI >=19-24kg/m2
• Physical examination, blood routine, urine routine, liver and kidney function and related laboratory tests are normal or slightly abnormal but not clinically significant;
• Read, agree, and sign the informed consent;
• Be able to communicate with the investigator and finish the study according to the protocol.

Exclusion Criteria （anyone or more of the following):

• Allergic to the API or excipients used (citric acid, mannitol, Meta-Cresol);
• Experiencing clinically significant disease or surgery within 4 weeks before the study;
• Clinically significant disease history in systems including cardiovascular system, endocrine system, neutral system, immunology system, psychiatry，metabolic disorder;
• Disease history of gastrointestinal tract, liver, and kidney (for example, the Partial resection surgery in GI tract, liver, or kidney);
• Fever history within 3 days of the screening;
• Clinical significant abnormality found in laboratory tests (blood, urine routine test) within 2 weeks before study;
• ECG or vital signs is clinically significant abnormality as judged by the Investigator( systolic blood pressure <90mmHg or ≥140mmHg; diastolic blood pressure<60mmHg or ≥90mmHg; heart rate <50bpm or >100bpm);
• Antibody test for HIV, BsAg, C hepatitis, or Microspironema pallidum positive;
• Alcoholics or drink frequently within 6 months of trial (more than 14 unit of alcohol, in which 1 unit is 360mL beers, or 45 ml wine with 40% alcohol content, or 150mL port wine;
• Addicted to cigarette, tea, coffee or drugs;
• Have specific requirement for diets (or allergic to any food);
• Have been administered in the past 2 weeks with any drug (such as antibiotics, anticoagulant, diuretics) that might interfere the PK profile of drug/drug candidate to be used in this study;
• Participated in any clinical trial in the past 3 months;
• Donated blood of more than 360 ml in the past 3 months;
• Plan to be pregnant herself or his spouse in the next 6 months;
• Females administered with any oral contraceptive 30 days before the study or during the study;
• Females dosed with long acting estrogen or progestin (injections or implant) 6 months before the study or during the study;
• Females at childbearing age that had unprotected intercourse 14 days before the study or will have during the study;
• Female who is pregnant or nursing;
• Anybody who might not be able to complete the study, or considered not appropriate by the investigator.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: NA
• Interventional Model: SINGLE_GROUP
• Masking: DOUBLE

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: Exenatide analogue, Injection; PB-119 will be administered once weekly subcutaneously at dosage of 2μg、5μg、10μg、25μg、50μg、100μg、200μg or 400μg.	Drug: PB-119

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Safety/Adverse Event Outcome Measure	Up to 3 weeks

Collaborators and Investigators

• Sponsor: PegBio Co., Ltd.
• Investigators: Principal Investigator: Yuan Lv, Doctor, No.1 Hospital of Peking University

Publications and helpful links

General Publications

• Cui H, Zhao CY, Lv Y, Wei MJ, Zhu Y, Li Y, Xia YH, Liu Y, Tian JH, Zhang P. Safety, Tolerability and Pharmacokinetics of Single Dose Polyethylene Glycolated Exenatide Injection (PB-119) in Healthy Volunteers. Eur J Drug Metab Pharmacokinet. 2020 Jun;45(3):361-369. doi: 10.1007/s13318-020-00605-9. Erratum In: Eur J Drug Metab Pharmacokinet. 2020 Apr 6;:

Study record dates

Study Major Dates

• Study Start: February 1, 2014
• Primary Completion (ACTUAL): November 1, 2014
• Study Completion (ACTUAL): November 1, 2014

Study Registration Dates

• First Submitted: March 9, 2014
• First Submitted That Met QC Criteria: March 9, 2014
• First Posted (ESTIMATE): March 11, 2014

Study Record Updates

• Last Update Posted (ACTUAL): February 14, 2017
• Last Update Submitted That Met QC Criteria: February 13, 2017
• Last Verified: February 1, 2017

More Information

Terms related to this study

• Keywords: safety,; pharmacokinetics,; Long acting GLP-1 analogue
• Additional Relevant MeSH Terms: Glucose Metabolism Disorders; Metabolic Diseases; Endocrine System Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2
• Other Study ID Numbers: ICP-I-2013-08