- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02119637
Effects of Transcranial Magnetic Stimulation (TMS) on Somatosensory Perception
Background:
- Different parts of the brain are involved in feeling touch. Researchers want to study whether repetitive magnetic stimulation (rTMS) to the sensory cortex affects how sensation feels. rTMS is a repeated magnetic pulse that interferes with brain activity. It affects a small part of the brain beneath the scalp. Researchers want to find out the role of sensory cortex in sensing different types of touch.
Objectives:
- To find out the role of sensory cortex, a brain area, in sensing different types of touch.
Eligibility:
- Healthy adults ages 18 45.
Design:
- Participants will be pre-screened with a telephone interview. Then they will be screened with physical and psychological exams and a urine test.
- In Session 1, participants will have an MRI brain scan and fill out questionnaires.
- For MRI, a magnetic field and radio waves take pictures of the brain. Participants will lie on a table that slides in and out of a metal cylinder. A coil will be placed over their head. They will perform a task during the scan. The scanner makes loud knocking noises. Participants will get earplugs. They will be in the scanner for up to 60 minutes.
- In Sessions 2 and 3, participants will take urine tests. Their perception of touch will be measured. Then rTMS will be used to stimulate their sensory cortex and scalp for about 20 minutes. Their perception of touch will be measured again.
- For rTMS, a wire coil is held on the scalp. A brief electrical current passes through the coil and creates a magnetic pulse that affects activity in the brain.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
Maryland
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Bethesda, Maryland, United States, 20892
- National Institutes of Health Clinical Center, 9000 Rockville Pike
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
INCLUSION CRITERIA:
- between 18 and 45 years old
- right-handed.
- Fluent in English.
- able to provide written informed consent.
EXCLUSION CRITEIRA:
- Has a dermatological condition such as scars, burns, callouses, or tattoos that might influence cutaneous sensibility on the hands
- Has had recent or permanent injury of upper limbs or amputation or use of prosthetic arm or leg
- Used recreational drugs within the past month
- Is pregnant or breastfeeding.
- Has a current chronic pain condition or has had chronic pain in the past (painful condition lasting more than six months).
- Has a major medical condition, such as kidney, liver, cardiovascular, autonomic, pulmonary, or neurological problems (including blindness or deafness) or a chronic systemic disease (e.g. diabetes).
- Has a medical condition potentially affecting somatosensation (e.g. Raynaud s Disease, peripheral neuropathy, or circulatory disorder).
- Participant has or had psychiatric disorders such as major depression, major anxiety-related problems, substance or alcohol dependence or abuse, post-traumatic stress syndrome, bipolar disorder, psychosis, or suicide attempts or persistent suicide ideation.
- Has metal implants or fragments in the body as this would make having an MRI scan unsafe. This includes pacemakers, medication pumps, aneurysm clips, metallic prostheses (such as metal pins and rods, heart valves or cochlear implants), shrapnel fragments, permanent eye liner or small metal fragments in the eye that welders and other metal workers may have.
- Is uncomfortable in closed spaces (has claustrophobia) so that he/she would feel uncomfortable in the MRI machine, or a condition that prevents him/her from lying flat for up to 1 hour or rotating palm up for 15 minutes while lying flat.
- Weight of 275 pounds or higher.
- History of head trauma that was diagnosed as a concussion or was associated with loss of consciousness or was associated with loss of consciousness.
- Personal history of a seizure or first degree relative with a seizure disorder
- Participation in brain stimulation within one week of any TMS session in this study
- Use of neuro-active drugs including opioids, antidepressants, anticonvulsants/antiepileptics, antipsychotics, dopamine agonists, sleep or anxiety medications, stimulants like methylphenidate (Ritalin), antihistamines, certain viral medications, or any other medication affecting the central nervous system
- History of hearing loss
- Obtained less than 6 hours of sleep the night before either TMS session (will be asked at each TMS session)
- Consumed more than 16oz of coffee or an energy drink (anything with 500mg caffeine or more) on the day of the TMS session. (Caffeine > 500mg and sleep deprivation can increase seizure risk (Engel J, 2008).
- Consumed alcohol on the day of the TMS session or shows signs of alcohol intoxication or alcohol withdrawal syndrome
- Motor threshold over 82% of Magstim output.
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Study 1 TMS to S1
Cohort of healthy participants received screening, brain MRI, TMS to S1 and vertex, and somatosensory testing, including 2-point discrimination and gentle brushing.
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1 Hz rTMS for 20 minutes.
TMS sessions were separated by at least 24 hours.
Anatomical MRI, resting state MRI and functional MRI using gentle brushing and finger movement
|
Study 2 TMS targeting S2/insula
Cohort of healthy participants received screening, brain MRI before and after TMS, TMS to S2/insula and vertex, and somatosensory testing, including 2-point discrimination and gentle brushing.
|
1 Hz rTMS for 20 minutes.
TMS sessions were separated by at least 24 hours.
Anatomical MRI, resting state MRI and functional MRI using gentle brushing and finger movement
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
2-point touch discrimination on hand during active and control rTMS sessions
Time Frame: 2 years
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Primary outcome for Study 1. Touched palm with one or two tips separated by 4 distances.
Subject reported if he/she felt one or two touches at each separation distance.
|
2 years
|
Collaborators and Investigators
Investigators
- Principal Investigator: Mary C Bushnell, Ph.D., National Center for Complementary and Integrative Health (NCCIH)
Publications and helpful links
General Publications
- Baron-Cohen S, Wheelwright S, Skinner R, Martin J, Clubley E. The autism-spectrum quotient (AQ): evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. J Autism Dev Disord. 2001 Feb;31(1):5-17. doi: 10.1023/a:1005653411471. Erratum In: J Autism Dev Disord 2001 Dec;31(6):603.
- Bolognini N, Rossetti A, Casati C, Mancini F, Vallar G. Neuromodulation of multisensory perception: a tDCS study of the sound-induced flash illusion. Neuropsychologia. 2011 Jan;49(2):231-7. doi: 10.1016/j.neuropsychologia.2010.11.015. Epub 2010 Nov 19.
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- 140100
- 14-AT-0100
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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