- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02144935
Collaborative Assessment of Pediatric Transverse Myelitis: Understand, Reveal, Educate or CAPTURE Study (TMCAPTURE)
Patients and families are invited to participate in an online registry and data repository specifically for patients with transverse myelitis (TM) or acute flaccid myelitis (AFM). The data generated in this study will come from surveys, interviews, review of medical records.
Data from this study will be utilized to guide future clinical trials for children with an acute case of TM or AFM. Parents and school aged children will complete an online survey 7 banks of questions. Each bundle of survey topics have 7-10 questions. We will have both the parent and child complete a outcomes based survey within 6 months of diagnosis and invite to participate every 4 months until study end in 2024.
Study Overview
Status
Detailed Description
Both parent and child will participate in the online questionnaires. The validated questionnaires, PROMIS or Patient-Reported Outcomes Measurement Information System, are blocks of 8-10 questions. 7 blocks of questions for the parent and 7 similar blocks for the child: anxiety, depressive symptoms, fatigue, mobility, pain interference, peer relationships, upper extremity function.
Participation via the Internet: When a child or family enters the Transverse Myelitis Association (TMA) website, they will be directed to information about the CAPTURE study. If the family is interested in participation, the TMA will give them the UT southwestern in Dallas, TX research coordinator information. It is up to the parent/guardian to contact the study staff from University Texas Southwestern. Once initial contact is complete, at the family's request, study staff will send the consent form to the interested family. The family will need to email or mail the consent back. Once the signed consent form is in hand, we will send the research survey to the email the parent provides. One survey for the parent, a separate but similar survey for a school aged child.
We will invite parents of school aged children to complete a school survey. This is a one time only questionnaire. Ideally, the parents will complete this either 6 months or 1 year into their child's recovery of TM/AFM.
We invite families living outside of North America to participate in the online survey. They need to be fluent in English, same as the North American cohort.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Texas
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Dallas, Texas, United States, 75235
- UTexasSouthwestern
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria for the registry:
- Diagnosis of transverse myelitis (TM) or acute flaccid myelitis (AFM)
- Patient is within 6 months of symptom onset
- Ability of patent or legal guardian is able to provide informed consent
- Ability of a child 10 or older able to provide assent
- Access to the internet
Exclusion Criteria for the registry:
- Inability to provide appropriate consent or assent
- Diagnosis of multiple sclerosis, neuromyelitis optica, or neuromyelitis optica spectrum disorder
Study Plan
How is the study designed?
Design Details
- Observational Models: Case-Only
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
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myelitis, transverse or acute flaccid myelitis
Observational study with online survey participation highlighting outcomes recovery.
The surveys can be completed by the child and parent, or if too young to participate, parent only.
The survey asks how the child is doing after hospitalization within 6 months of diagnosis, and every 4 months until study end in 2024.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
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Patient and parent reported symptoms of recovery
Time Frame: up to one year post symptom onset
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each parent /guardian and child will fill out a questionnaire examining how you feel about your ability to move and your emotions.
This is completed at 3,6,and 12 months after symptoms are diagnosed.
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up to one year post symptom onset
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
ASIA scale
Time Frame: up to one year after symptom diagnosis
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We will measure the motor (movement) and sensory (touch) of the child above and below the spinal lesion.
This is completed at 3 time points 3,6,and 12 months post symptom onset.
For the secondary outcomes, the family needs to be able to travel to 1 of the 5 centers listed in the study.
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up to one year after symptom diagnosis
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Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Benjamin Greenberg, MD, UT Southwestern
Publications and helpful links
Helpful Links
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Central Nervous System Diseases
- Nervous System Diseases
- Infections
- Immune System Diseases
- Neoplasms
- Demyelinating Autoimmune Diseases, CNS
- Autoimmune Diseases of the Nervous System
- Demyelinating Diseases
- Autoimmune Diseases
- Neoplasms by Site
- Neurologic Manifestations
- Central Nervous System Infections
- Neurodegenerative Diseases
- Spinal Cord Diseases
- Nervous System Neoplasms
- Paraneoplastic Syndromes, Nervous System
- Paraneoplastic Syndromes
- Paralysis
- Paraplegia
- Myelitis
- Myelitis, Transverse
Other Study ID Numbers
- 012014-077 (Other Identifier: UTSW IRB)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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