Chronotherapy Randomized Controlled Trial

Adjunct Total Sleep Deprivation, Sleep Phase Advance, and White Light Therapy Vs. Partial Sleep Deprivation, Sleep Phase Delay, and Amber Light Therapy as Adjunctive Treatments in Acutely Suicidal and Depressed Inpatients.

Chronotherapy is a term that describes therapeutic alterations of sleep wake cycles. Different variations of sleep deprivation, set sleep wake schedules, and types of light therapy have demonstrated efficacy in rapidly treating depression, and suicidal thinking. This study seeks to explore the effect of two different chronotherapuetic protocols on acutely depressed and suicidal inpatients admitted to the Medical University of South Carolina

Study Overview

• Status: Terminated
• Conditions: Suicidal Ideation; Bipolar Depression; Major Depressive Disorder
• Intervention / Treatment: Other: Treatment as usual; Behavioral: Total Sleep deprivation, Sleep Phase Advance, and Bright Light Therapy; Behavioral: Partial Sleep deprivation, Sleep Phase Delay, and Low amber light.

Detailed Description

There is a consistently reported, rapid antidepressant response to a single night of total sleep deprivation in both unipolar, and bipolar depression. The clinical utility of this technique has been limited however, because responders have typically relapsed rapidly following recovery sleep. The addition of pharmacotherapy, sleep phase advance (a shift to an earlier sleep schedule with normalization over three days), and bright light therapy to sleep deprivation have each demonstrated efficacy in preventing relapse into depression. Combined total sleep deprivation, sleep phase advance, and bright light therapy, dubbed Triple Chronotherapy along with concomitant pharmacotherapy has demonstrated a rapid improvement in depressive symptoms that has remained durable for as long as 9 weeks post intervention. If the early, encouraging results of Triple Chronotherapy hold up to further study, the technique represents a near ideal inpatient treatment, as it is inexpensive, relatively easy to carry out, and has minimal side effects.

Despite encouraging early results, only one published report has attempted to use triple chronotherapy in suicidal patients, and in that trial only bipolar depressed patients were included, and one single variation of chronotherapy was tested (Three nights of sleep deprivation every other night with three light therapy sessions, combined with lithium). The lack of data in acutely suicidal patients significantly limits the utility of this intervention in the United States, where few non-suicidal patients are admitted. Published trials to this point have also excluded those with comorbid illness, which also limits the clinical usefulness of this intervention to a minority of patients. Furthermore there are sparse randomized adequately controlled trials, and still limited durability data on the technique.

We recently explored the tolerability and feasibility of the technique on acutely depressed and suicidal inpatients admitted to our inpatient unit with encouraging results. We subsequently propose to further explore the utility of this technique by piloting its effect compared to an active sham condition to determine if further study is indicated. Should further study be warranted, we hope to use the collected pilot data to determine the necessary number of participants to detect an effect.

• Study Type: Interventional
• Enrollment (Actual): 13
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • South Carolina
    • Charleston, South Carolina, United States, 29401
      • Medical University of South Carolina

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 90 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• A current episode of non-psychotic major depression
• Currently hospitalized
• Age greater than 18
• If bipolar illness, must not be a mixed state, and must be on a therapeutic dose of a mood stabilizer

Exclusion Criteria:

• Urine drug screen positive for cocaine, or current alcohol/dependence that requires detox
• current psychosis
• Panic Disorder
• Severe Borderline Personality Disorder
• A history of seizures, uncontrolled severe headaches, stroke, or other neurologic illness that produces either gait abnormalities or lowered seizure threshold
• Medical illness that would make wake therapy intolerable
• Cataracts, glaucoma, or other intrinsic eye condition
• Currently taking light sensitizing medications
• Current pregnancy
• Mental retardation or dementia
• Untreated sleep disorder such as Obstructive Sleep Apnea(OSA), narcolepsy, or periodic limb movement disorder(PLMD) that results in excessive sleepiness
• Currently receiving electroconvulsive therapy (ECT)

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: RANDOMIZED
• Interventional Model: PARALLEL
• Masking: DOUBLE

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: Triple Chronotherapy; Total Sleep Deprivation, Sleep phase advance, and Bright Light Therapy. Carex Health Brands Day-Light Classic 10,000 Lux	Behavioral: Total Sleep deprivation, Sleep Phase Advance, and Bright Light Therapy; Sleep deprivation, Sleep phase advance, and Bright light therapy
SHAM_COMPARATOR: Sham Triple Chronotherapy; Total sleep deprivation, Three day fixed wake schedule, and sham light therapy.	Behavioral: Partial Sleep deprivation, Sleep Phase Delay, and Low amber light.; Other Names: Carex Health Brands Day-Light Classic 10,000 LUX with custom amber filter from lowbluelights.com
ACTIVE_COMPARATOR: Treatment As Usual; Normal inpatient care including pharmacotherapy, psychotherapy, milieu therapy, and social work interventions.	Other: Treatment as usual

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Hamilton Depression Rating Scale	Change in scores from Pre and Post Hamilton Depression scores	Day prior to total sleep deprivation, and then again over the next 4 consecutive days. There will then be a continuation phase where data will be collected at one week, two weeks, 4 weeks, and 8 weeks.
Columbia Suicide Severity Rating Scale	Change in score of Columbia Suicide Severity Rating Scale	Day prior to total sleep deprivation, and then again over the next 4 consecutive days. There will then be a continuation phase where data will be collected at one week, two weeks, 4 weeks, and 8 weeks.

Collaborators and Investigators

• Sponsor: Medical University of South Carolina

Study record dates

Study Major Dates

• Study Start: June 1, 2014
• Primary Completion (ACTUAL): April 7, 2016
• Study Completion (ACTUAL): April 7, 2016

Study Registration Dates

• First Submitted: June 24, 2014
• First Submitted That Met QC Criteria: June 24, 2014
• First Posted (ESTIMATE): June 27, 2014

Study Record Updates

• Last Update Posted (ACTUAL): May 30, 2019
• Last Update Submitted That Met QC Criteria: May 29, 2019
• Last Verified: May 1, 2019

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Behavioral Symptoms; Mental Disorders; Nervous System Diseases; Mood Disorders; Dyssomnias; Sleep Wake Disorders; Neurologic Manifestations; Bipolar and Related Disorders; Self-Injurious Behavior; Suicide; Depressive Disorder; Bipolar Disorder; Suicidal Ideation; Depressive Disorder, Major; Sleep Deprivation
• Other Study ID Numbers: Chronotherapy RCT