Thyroid Disorders in Malaysia: A Nationwide Multicentre Study (MyEndo-Thyroid)

Thyroid Disorders in Malaysian: A Nationwide Multicentre Study

This will be a population based study looking at the prevalence of thyroid disorders in Malaysia (including hypo- and hyperthyroidism, subclinical hypo- or hyperthyroidism) and its association with different ethnicity and iodine status. The study will also look at genetic susceptibility for autoimmune thyroid disorders in the Malaysian population

General hypotheses:

The prevalence of thyroid disorders in Malaysia is 10% for hypothyroidism and 2% for hyperthyroidism Hypo- and hyperthyroidism is associated with iodine status in our population There are different susceptibility gene for autoimmune thyroid disorder in different ethnicity in our population

Study Overview

• Status: Completed
• Conditions: Hypothyroidism; Graves Disease; Hyperthyroidism; Subclinical Hypothyroidism; Iodine Deficiency; Genetic Susceptibility; Subclinical Hyperthyroidism; Hashimoto's Thyroiditis

Detailed Description

This will be a cross-sectional population based study involving Malaysian adults (aged 18 year old and above). Cluster sampling will be used to select respondents that will be representative of the Malaysian population. Selected respondent will be interviewed, anthropometric measurement taken, blood and urine sample taken.

Blood will be analyzed for thyroid function (thyroxine, triiodothyronine and thyroid stimulating hormone), autoantibodies (anti-thyroperoxidase and anti-thyroglobulin). Urine will be analyzed for urinary iodine.

Those diagnosed with autoimmune thyroid disorders with strong family history of thyroid disorders (multiplex multi-generation family involvement) will have their blood sent for whole exome sequencing and linkage analysis done to identify possible susceptible gene for autoimmune thyroid disorders

Respondents detected to have hypo- or hyper- and subclinical hypo- or hyperthyroidism will be referred to their nearest health centre for further evaluation and treatment appropriate for their condition.

• Study Type: Observational
• Enrollment (Actual): 2498

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Adult (aged equal or more than 18 years old ) Malaysian citizen living in Malaysia at the time of sampling

Description

Inclusion Criteria:

• Aged equal or more than 18 years old at the time of sampling
• Malaysian citizen

Exclusion Criteria:

• Respondents who did not give consent

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Number of participants with abnormal thyroid function	Overt or subclinical hypothyroidism Overt or subclinical hyperthyroidism	Day 0

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Number of participants with positive thyroid autoantibodies	Anti-thyroglobulin Anti-thyroperoxidase	Day 0
Number of participants with Iodine deficiency status	Urinary iodine level	Day 0

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Number of participants with genetic susceptibility to autoimmune thyroid disorders	whole exome sequencing and linkage analysis in families with autoimmune thyroid disorders (multiplex multi-generation involvement)	Day 0

Collaborators and Investigators

• Sponsor: International Islamic University Malaysia
• Collaborators: University of Malaya; National University of Malaysia; International Medical University; Malaysian Endocrine and Metabolic Society
• Investigators: Principal Investigator: Nor Azmi Kamaruddin, MBBS, MMed, National University of Malaysia; Principal Investigator: Norlela Sukor, MMed, Phd, National University of Malaysia; Principal Investigator: Norhanita Othman, National University of Malaysia; Principal Investigator: Johari Ali, University of Malaya; Principal Investigator: Shirenee Vethakkan, University of Malaya; Principal Investigator: Siew Kim Kwa, International Medical University; Principal Investigator: Kuck Meng Chong, MD, Malaysian Endocrine and Metabolic Society; Principal Investigator: Lecthuman Ramanathan, Malaysian Endocrine and Metabolic Society; Principal Investigator: Hussein Zanariah, Malaysian Endocrine and Metabolic Society; Principal Investigator: Nurain Mohd Noor, Malaysian Endocrine and Metabolic Society; Principal Investigator: Norhaliza Mohd Ali, Malaysian Endocrine and Metabolic Society; Principal Investigator: Norhayati Yahya, Malaysian Endocrine and Metabolic Society; Principal Investigator: Nor Azizah Aziz, Malaysian Endocrine and Metabolic Society

Study record dates

Study Major Dates

• Study Start: August 1, 2014
• Primary Completion (ACTUAL): September 1, 2016
• Study Completion (ACTUAL): September 1, 2016

Study Registration Dates

• First Submitted: July 9, 2014
• First Submitted That Met QC Criteria: July 11, 2014
• First Posted (ESTIMATE): July 15, 2014

Study Record Updates

• Last Update Posted (ESTIMATE): October 18, 2016
• Last Update Submitted That Met QC Criteria: October 17, 2016
• Last Verified: October 1, 2016

More Information

Terms related to this study

• Keywords: Hypothyroidism; Hyperthyroidism; Iodine deficiency; Genetic susceptibility; Autoimmune thyroid disorders
• Additional Relevant MeSH Terms: Pathologic Processes; Immune System Diseases; Autoimmune Diseases; Eye Diseases; Endocrine System Diseases; Disease Attributes; Exophthalmos; Orbital Diseases; Goiter; Thyroiditis, Autoimmune; Hypothyroidism; Thyroid Diseases; Hyperthyroidism; Disease Susceptibility; Genetic Predisposition to Disease; Hashimoto Disease; Graves Disease; Thyroiditis
• Other Study ID Numbers: MyEndo-Thyroid