Adaptive Cognitive Training in Healthy Older Adults

July 31, 2019 updated by: Bruyere Research Institute
Cognitive training has emerged as a promising method to maintain, enhance, and rehabilitate cognitive function in older adults and individuals with dementia. In recent years, such training has become particularly appealing in the clinical context, with many paradigms aimed specifically at adults experiencing various stages of cognitive decline due to Mild Cognitive Impairment, Alzheimer's disease, and vascular dementias. However, basic questions remain. For example, uncertainty persists regarding factors that influence observed improvements as well as the conditions that would maximize transfer and sustainability of training effects. The objective of this study is to evaluate factors that may maximize the benefits of computerized cognitive training in older adults.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The study involves 25 sessions of an adaptive cognitive training program, completed over 5 weeks. Pre and post training assessments will evaluate any near and far transfer effects of training.

Study Type

Interventional

Enrollment (Actual)

99

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Canada
    • Ontario
      • Ottawa, Ontario, Canada, K1N 5C8
        • Bruyère Continuing Care

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

60 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • English as the maternal or primary spoken language.
  • Good self-reported health (i.e., no cerebro-, or cardio-vascular disease or neurological disease).
  • Normal or corrected-to-normal vision and hearing.

Exclusion Criteria:

  • Poor hearing or vision
  • Inadequate understanding of the English language

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Computerized cognitive training
Series of gamified tasks.
Other: Computerized cognitive training
Other Names:
  • Activate
Placebo Comparator: Computerized game training
Series of gamified tasks.
Other: Computerized games

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in ratings on cognitive training survey
Time Frame: Baseline, week 5
This survey aims to assess participant perceptions on cognitive training, and includes a series of related questions, rated on a scale of 1-7.
Baseline, week 5
Change in neural activity
Time Frame: Baseline, week 5
We will measure resting state as well as task-related EEG responses to determine the effects of cognitive training at the neural level.
Baseline, week 5
Change in performance on neuropsychological tests
Time Frame: Baseline, week 5
Using a set of standard neuropsychological evaluations, we will measure changes in attention, memory, and executive function following cognitive training.
Baseline, week 5

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in ratings of psychological wellbeing
Time Frame: Baseline, week 5
We will use standardized questionnaires to assess quality of life, in order to measure the influence of cognitive training on factors related to wellbeing.
Baseline, week 5

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Bruyere Research Institute

Collaborators

University of Ottawa

Investigators

  • Principal Investigator: Patrick Davidson, PhD, University of Ottawa
  • Study Director: Sheida Rabipour, MSc, University of Ottawa

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

August 1, 2016

Primary Completion (Actual)

August 1, 2018

Study Completion (Actual)

August 1, 2018

Study Registration Dates

First Submitted

July 29, 2014

First Submitted That Met QC Criteria

July 30, 2014

First Posted (Estimate)

July 31, 2014

Study Record Updates

Last Update Posted (Actual)

August 2, 2019

Last Update Submitted That Met QC Criteria

July 31, 2019

Last Verified

August 1, 2017

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • M16-14-018

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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