- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02208609
Zinc Bioavailability From Amaranth-enriched Maize Tortillas
April 27, 2016 updated by: University of Colorado, Denver
Absorption of Zinc (Zn) From Traditional Maize Tortillas and Amaranth-enriched Tortillas by Toddlers in the Indigenous Post-Mayan Population
Young children in Guatemala are at risk for nutrient deficiencies due to plant-based diets and poor sanitation.
Stunting, frequent diarrhea, and respiratory infections are common.
Supplementation of Zn to children during diarrhea episodes has been shown to diminish duration and severity of illness.
Poor Zn absorption due to high fiber and phytate in this diet might play a role in these processes.
Supplementation of this micronutrient in the diet might be beneficial.
The investigators will compare absorption of Zn from white maize tortillas enriched with 20% amaranth to traditional white corn tortillas in preschool children in Guatemala.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
This is a randomized cross-over study of zinc absorption in young children living in the Western Highlands of Guatemala.
Absorption of zinc will be measured from maize tortillas and maize tortillas fortified with 20% amaranth as the major food staple which provides at least 70% energy and at least 90% zinc and phytate of the diet.
Participants will be randomized as to which type of tortilla they receive on the first and second day.
Fractional absorption of zinc (FAZ) from all meals in one day for one type of tortilla and one day for the other will be measured by extrinsic labeling with stable isotopes of zinc.
FAZ will be measured by a dual isotope tracer ratio (DITR) technique based on ratio of urine enrichment of orally versus intravenously administered zinc stable isotopes.
Measurement of total zinc in duplicate diets on test days allow for determination of quantities of this micronutrient absorbed.
Study Type
Interventional
Enrollment (Actual)
20
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Guatemala City, Guatemala
- Universidad Francisco Marroquín
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Colorado
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Aurora, Colorado, United States, 80045
- University of Colorado Anschutz Medical Campus
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
1 year to 3 years (Child)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- 2-3 years of age
- apparently healthy
- eats >2-3 tortillas at each meal of the day.
Exclusion Criteria:
- Chispitas or macrovital supplementation
- breastfeeding
- birth weight < 2,500 g
- birth defect affecting growth and development
- chronic infection
- twin or triplet
- sibling enrolled in study
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Maize Tortillas with 20% Amaranth
Children in this arm were fed maize tortillas fortified with 20% amaranth
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Subjects received Maize tortillas with 20% Amaranth added.
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Experimental: Maize Tortillas without 20% Amaranth
Children in this arm were fed maize tortillas without amaranth
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Maize tortillas without Amaranth.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Zinc Absorption
Time Frame: 2 days
|
Absorption of zinc will be compared in young children when fed the common maize tortilla and a tortilla fortified with 20 % amaranth.. Fractional absorption of zinc for a day will be measured by extrinsic labeling with stable isotopes of zinc.
Fractional absorption of zinc will be measured by a dual isotope tracer ratio technique.
Measurement of total zinc in duplicate diets on test day will allow determination of quantity of this micronutrient absorbed (mg/d).
|
2 days
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2012
Primary Completion (Actual)
December 1, 2015
Study Completion (Actual)
December 1, 2015
Study Registration Dates
First Submitted
August 1, 2014
First Submitted That Met QC Criteria
August 4, 2014
First Posted (Estimate)
August 5, 2014
Study Record Updates
Last Update Posted (Estimate)
April 29, 2016
Last Update Submitted That Met QC Criteria
April 27, 2016
Last Verified
April 1, 2016
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 13-0282
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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