Effects of Aloe Vera Toothpaste on Periodontal Parameters

Effects of Aloe Vera Toothpaste on Periodontal Parameters of Patients With Gingivitis

This study aimed to assess the effects of Aloe Vera toothpaste on dental plaque and gingivitis.

The single-blind cross-over clinical trial was conducted on 20 dental students (10 males and 10 females with a mean age of 24.5±4 yrs.) with gingivitis. Students were randomly divided into 2 groups. The first group used Aloe Vera toothpaste for 30 days. A 2-week wash-out period was allowed and then subjects used fluoride toothpaste for the next 30 days . This order was reversed in group 2.

Study Overview

• Status: Completed
• Conditions: Gingivitis
• Intervention / Treatment: Other: Foramen Herbal Aloe toothpaste; Other: fluoride toothpaste

Detailed Description

Toothpastes are used with tooth brushing to better control microbial plaque. Herbal toothpastes have recently gained attention. This study aimed to assess the effects of Aloe Vera toothpaste on dental plaque and gingivitis.

This single-blind cross-over clinical trial was conducted on 20 dental students (10 males and 10 females with a mean age of 24.5±4 yrs.) with gingivitis. Students were randomly divided into 2 groups. The first group used Aloe Vera toothpaste for 30 days and then their plaque index (PI) and gingival index (GI) were recorded. A 2-week wash-out period was allowed and then subjects used fluoride toothpaste for the next 30 days and underwent PI and GI assessment again. This order was reversed in group 2. Wilcoxon-Sign Rank and two way Repeated Measure ANOVA tests were applied for statistical analysis.

• Study Type: Interventional
• Enrollment (Actual): 20
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Iran, Islamic Republic of
  • Tehran, Iran, Islamic Republic of, 19585175
    • Tehran Dental Branch, Islamic azad University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 24 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Subjects were selected among dental students with at least 20 natural teeth without systemic disease
• No periodontal treatment at least 6 months to the study
• No use of systemic antibiotic and anti-inflammatory drugs within the last 3 months, nonsmokers, no pregnancy or lactating women
• Subjects with PD≤3mm, (clinical attachment level)CAL<1mm, PI≥2 and gingival bleeding in more than 30% of the tested areas were enrolled with the diagnosis of plaque-related gingivitis.

Exclusion Criteria:

• Subjects with orthodontic appliances ,multiple bridges, partial denture, multiple caries were excluded from the study

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Foramen Herbal Aloe toothpaste; test group was asked to brush the teeth with Foramen Herbal Aloe toothpaste for 30 days once a day.	Other: Foramen Herbal Aloe toothpaste; use of aloe-vera toothpaste for 30 days in the test group.
Active Comparator: use of fluoride toothpaste (signal); use of a fluoride toothpaste (signal) in control group once a day for 30 days .	Other: fluoride toothpaste; use of signal toothpaste once a day for 30 days in the control group.; Other Names: signal

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
measuring gingival index	to compare the efficacy of the aloe-vera toothpaste with a known conventional toothpaste, the gingival index was recorded at baseline and after 30 days of consumption and compared with the two understudy toothpastes.	1-2days

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
measuring gingival index	to compare the efficacy of the aloe-vera toothpaste with a known conventional toothpaste, the gingival index was recorded at baseline and after 30 days of consumption and compared with the two understudy toothpastes.	1-2 days
measuring plaque index	to compare the efficacy of the aloe-vera toothpaste with a known conventional toothpaste, the plaque index was recorded at baseline and after 30 days of consumption and compared with the two understudy toothpastes.	1-2 days

Collaborators and Investigators

• Sponsor: Islamic Azad University, Tehran
• Investigators: Principal Investigator: Ferena Sayar, DDS;MSc, Tehran Dental Branch, Islamic Azad University,Tehran/Iran

Study record dates

Study Major Dates

• Study Start: September 1, 2013
• Primary Completion (Actual): February 1, 2014
• Study Completion (Actual): June 1, 2014

Study Registration Dates

• First Submitted: August 30, 2014
• First Submitted That Met QC Criteria: September 9, 2014
• First Posted (Estimate): September 10, 2014

Study Record Updates

• Last Update Posted (Estimate): January 14, 2015
• Last Update Submitted That Met QC Criteria: January 13, 2015
• Last Verified: January 1, 2015

More Information

Terms related to this study

• Keywords: clinical trial; anti-inflammatory agents; oral hygiene; Gingivitis; Toothpaste; Aloevera
• Additional Relevant MeSH Terms: Infections; Stomatognathic Diseases; Periodontal Diseases; Mouth Diseases; Gingival Diseases; Gingivitis; Physiological Effects of Drugs; Protective Agents; Cariostatic Agents; Fluorides
• Other Study ID Numbers: IRCT2014040517053N2