Evaluation of Conventional Antibiotic Prophylaxis During a Change of Hip or Knee Infected at a Time

Evaluation of the Effect of a Conventional Antibiotic Prophylaxis on the Positivity of Intraoperative Bacteriological Samples During a Change of Hip or Knee Infected at a Time

Infection is a serious complications after undergoing total hip replacement. It occurs in about 1% of cases. The optimal treatment of these infections is discussed. The team validated by international publications change strategy of the infected prosthesis at a time.

Antibiotic prophylaxis has significantly reduced the infection intraoperative contamination in orthopedic surgery rates. It must be conventionally administered before the surgical incision. In response to infection, it is typically recommended to start this antibiotic after the completion of the deep bacteriological samples, so as not to negate the risk of these samples by the prior administration of antibiotics. This attitude, however, is not formally validated by the scientific literature. In contrast, two recent publications challenge this practice, and suggest the use of a conventional antibiotic prophylaxis even in septic interventions. Our multidisciplinary team opted for a few months for this new strategy. We wish to evaluate the influence of this new approach results in the treatment of infection in total hip or knee.

Study Overview

• Status: Completed
• Conditions: Total Hip Replacement
• Intervention / Treatment: Other: Retrospective analysis of records

• Study Type: Observational
• Enrollment (Actual): 80

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

80 patients operated in service between January 2012 and July 2013 for treatment of an infection of total hip or knee.

Description

Inclusion Criteria:

• patients operated in service between January 2012 and July 2013 for treatment of an infection of total hip or knee.

Exclusion Criteria:

• patients operated in service before January 2012 and after July 2013 for treatment of an infection of total hip or knee.

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Retrospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
concordance of pre-and intraoperative bacteriological documentation	concordance of pre-and intraoperative bacteriological documentation (division into 3 classes: complete, partial, no - Chi-square test	preoperative; intraoperative

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
rates to relapse of the initial infection or a new infection	rates to relapse of the initial infection or a new infection (survival curves according to Kaplan-Meier with log-rank test)	preoperative; intraoperative

Collaborators and Investigators

• Sponsor: University Hospital, Strasbourg, France

Study record dates

Study Major Dates

• Study Start (Actual): November 1, 2014
• Primary Completion (Actual): October 31, 2017
• Study Completion (Actual): October 31, 2017

Study Registration Dates

• First Submitted: October 20, 2014
• First Submitted That Met QC Criteria: October 20, 2014
• First Posted (Estimated): October 22, 2014

Study Record Updates

• Last Update Posted (Estimated): September 5, 2025
• Last Update Submitted That Met QC Criteria: September 4, 2025
• Last Verified: September 1, 2025

More Information

Terms related to this study

• Keywords: Hip replacement; Knee replacement; Antibiotic prophylaxis; Knee infection; Hip infection
• Other Study ID Numbers: 004-14