- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02281695
PEEP Influence on Gas Exchange During Early Weaning (MHOPEEP)
The Influence of Different PEEP Values on Gas Exchange in Spontaneously Breathing Patients During Early Weaning
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
First, during controlled mechanical ventilation all patients will be ventilated for 5 minutes with 100% oxygen. After 5 minutes an PaO2/FiO2 will be calculated and compared with a PaO2/FiO2 during ventilation with FiO2 - 30%.
The patients will be divided in two sections: Section A are the patients with less than 24 hours mechanical ventilation until weaning start. Section B are the patients with more than 24 hours until weaning start.
The patients in every section will be further divided in two groups. Group 1 will be weaned starting with a PEEP equal with P mean during BiPAP, Group 2 will be weaned starting with a PEEP equal with PEEP during BiPAP.
Further, the weaning will be conducted after an known algorithm. The differences in the oxygenation and decarboxylation will be measured after 30 and 120 Minutes for Group A and after 30, 120, 240, 360 Minutes for Group B.
Study Type
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Niedersachsen
-
Osnabrück, Niedersachsen, Germany, 49074
- Marienhospital Osnabrück
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- All Patients that are mechanical ventilated on the intensive care unit.
Exclusion Criteria:
- Patients under 18 years of age
- Patients that where in an other study in the last 30 days
- Patients that are enrolled in other studies
- Pregnant woman
- Nursing mothers
- Existing severe Lung disease
- Existing COPD Gold IV
Study Plan
How is the study designed?
Design Details
- Primary Purpose: SUPPORTIVE_CARE
- Allocation: RANDOMIZED
- Interventional Model: SINGLE_GROUP
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
ACTIVE_COMPARATOR: Arm A
Patients that are mechanically ventilated for less than 24 hours until the weaning process can be started. At the beginning of the weaning process the PEEP will be adjusted at a value equal with the PEEP during BiPAP (Group 1) and Pmean during BiPAP (Group 2) During controlled mechanical ventilation all patients will be for 5 minutes with FiO2 - 100% ventilated. The PaO2/FiO2 after 5 minutes ventilation with 100% oxygen will be compared with the PaO2/FiO2 during ventilation with 30% oxygen. |
The PEEP will be adjusted after an previously established algorithm and the differences in the arterial blood oxygen partial pressure will be compared.
|
ACTIVE_COMPARATOR: Arm B
Patients that are mechanically ventilated for more than 24 hours until the weaning process can be started.
At the beginning of the weaning process the PEEP will be adjusted at a value equal with the PEEP during BiPAP (Group 1) and Pmean during BiPAP (Group 2) During controlled mechanical ventilation all patients will be for 5 minutes with FiO2 - 100% ventilated.
The PaO2/FiO2 after 5 minutes ventilation with 100% oxygen will be compared with the PaO2/FiO2 during ventilation with 30% oxygen.
|
The PEEP will be adjusted after an previously established algorithm and the differences in the arterial blood oxygen partial pressure will be compared.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Changes in the Oxygen Partial Pressure and CO2 Partial Pressure in the arterial blood gas analysis
Time Frame: 30, 60, 90, 120, 360 Minutes
|
30, 60, 90, 120, 360 Minutes
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Martin Beiderlinden, P.D. dr. - med., Marienhospital Osnabrück
Study record dates
Study Major Dates
Study Start (ACTUAL)
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- MHO 001
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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