Efficacy Study of an Olfactory Stimulation Program for the Recuperation of Autobiographical Memories in Anorexia (OLFANOR)

April 17, 2026 updated by: Lille Catholic University

Efficacy Study of an Olfactory Stimulation Program in Relaxing Environment for the Recuperation of Autobiographical Memories in Anorexic Patients

The purpose of this study is to estimate the impact of an olfactive stimulation, in relaxing environment, on the access at the autobiographical memories in anorexic patients.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

100

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Lille, France
        • Groupement des Hôpitaux de l'Institut Catholique de Lille

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

13 years to 24 years (Child, Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Eating disorders, anorexia (restrictive form or mixed) according to DSM IV-TR ( Diagnostic and Statistical Manual of Mental Disorders IV - Text Revision) criteria
  • Patient hospitalized in a department of one of the inquiring centers for a minimal duration of 5 weeks
  • French language ability
  • Coverage by the social insurance
  • Fully informed patient who consent to participate in the study

Exclusion Criteria:

  • Major mental associated disorders (psychotic disorders, bipolar disorder, major depression), neurological disorders or addiction to substances
  • Psychotropic treatment (with the exception of antidepressants, anxiolytics and sleeping drugs, if the treatment was started more than 30 days ago)
  • Any disorder susceptible to alter the reasoning capacities, discernment or judgment
  • Physically or psychologically unable to answer questionnaires

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Supportive Care
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Program
olfactory stimulation program
Behavioral: olfactory stimulation program

8 individual sessions of olfactory stimulation at the rate of 2 sessions per week. 3 semi-directed interviews will be help (one at the beginning of the trial, the second 5 weeks later and the third at 6 month).

For each session, patients have to smell two different odors (previously selected from a panel presented to the patient during first visits) and then they are invited to evoke memories and feelings related to each odor.
No Intervention: Control
normal follow-up

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Proportion of reminded specific autobiographical memories (Autobiographical Memory Test (AMT)
Time Frame: After 5 weeks
Autobiographical Memory Test (AMT) at inclusion and 5 weeks after
After 5 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Body mass index
Time Frame: first day of enrollment and 5 weeks after
Evaluation of size and weight
first day of enrollment and 5 weeks after
Evaluation of the specific memories recovery stimulation on the emotional differentiation ability (Level of Emotional Awareness Scale (LEAS)
Time Frame: first day of enrollment and 5 weeks after
Level of Emotional Awareness Scale (LEAS)
first day of enrollment and 5 weeks after
Evaluation of mental rumination (Cambridge Exeter Rumination Thinking Scale)
Time Frame: first day of enrollment and 5 weeks after
Cambridge Exeter Rumination Thinking Scale
first day of enrollment and 5 weeks after
Evaluation of anxiety and depression (Hospital Anxiety and Depression Scale)
Time Frame: first day of enrollment and 5 weeks after
Hospital Anxiety and Depression Scale
first day of enrollment and 5 weeks after
Evaluation of eating behaviors (Eating Disorder Inventory)
Time Frame: first day of enrollment and 5 weeks after
Eating Disorder Inventory
first day of enrollment and 5 weeks after
Evaluation of history of abuse (Childhood Trauma Questionnaire)
Time Frame: first day of enrollment and 5 weeks after
Childhood Trauma Questionnaire
first day of enrollment and 5 weeks after
Evaluation of cognitive avoidance strategies (Questionnaire of cognitive avoidance)
Time Frame: first day of enrollment and 5 weeks after
Questionnaire of cognitive avoidance
first day of enrollment and 5 weeks after

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Lille Catholic University

Investigators

  • Study Director: Vincent Dodin, Groupement des Hôpitaux de l'Institut Catholique de Lille

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

June 1, 2014

Primary Completion (Actual)

September 1, 2017

Study Completion (Actual)

July 1, 2018

Study Registration Dates

First Submitted

November 4, 2014

First Submitted That Met QC Criteria

November 20, 2014

First Posted (Estimated)

November 21, 2014

Study Record Updates

Last Update Posted (Actual)

April 20, 2026

Last Update Submitted That Met QC Criteria

April 17, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • RC-P0028

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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