Evaluation of Myocardial Viability : Dual Energy Cardiac CT vs. Cardiac MRI (InfarctusGSI)

April 9, 2026 updated by: University Hospital, Rouen

Evaluation of Myocardial Viability in Late Presentation Myocardial Infarction: Dual Energy Cardiac CT vs. Cardiac MRI.

The purpose of this study is therefore to show that associated with cardiac angiography echocardiography, in myocardial seen late, would provide the information necessary for the decision revascularization, in a timely manner.

This would allow the patient to avoid duplication of tests including risk related to coronary angiography (bleeding complications, stroke ...) and those related to the implantation of coronary stent (stent) without expected earnings in case of non-viability . This would also reduce the length of hospital stay and costs due to numerous reviews.

Study Overview

Status

Terminated

Conditions

Intervention / Treatment

Detailed Description

Percutaneous coronary intervention is not recommended in stable patients with late presentation myocardial infarction, and myocardial viability needs to be evaluated before the procedure. The aim of the study is to evaluate the sensibility and specificity of dual-energy CT for the evaluation of myocardial viability in comparison to cardiac MRI.

The experimental procedure is limited to a second CT acquisition performed 10 minutes in dual energy mode.

Sensitivity and Specificity of delayed enhancement >50% of myocardial thickness provided by dual-energy CT will be evaluated in comparison to cardiac MRI.

Study Type

Interventional

Enrollment (Actual)

31

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
    • Normandy
      • Rouen, Normandy, France, 76031
        • University Hospital of Rouen

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Man or woman
  • Major patient
  • Patient with electrical, biological and clinical signs of myocardial infarction, with late presentation (>24 hours)
  • Creatinine clearance (calculated using the Cockcroft (<age 65) or MDRD (> 65 years))formula > 30 ml / min.
  • Affiliation to the french social security scheme.
  • Women of childbearing age: Negative pregnancy test (urine test).
  • Postmenopausal women, menopause confirmation of diagnosis
  • Patient able to understand the spoken and written French.
  • Signature of informed consent

Exclusion Criteria:

  • Collapsus or organ failure requiring urgent care in intensive care unit
  • Arrhythmia and/or non-reducible tachycardia.
  • History of allergic reaction after iodinated contrast medium injection.
  • History of nephrogenic systemic fibrosis.
  • History of claustrophobia
  • Unbalanced asthma.
  • Acute pulmonary edema.
  • Pregnant or breastfeeding women.
  • Clinical signs of thyrotoxicosis.
  • Person placed under judicial protection,
  • Patient suffering from serious psychiatric disease.
  • Patients participating in another clinical trial.
  • Contraindication to MRI

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Diagnostic
  • Allocation: N/A
  • Interventional Model: Single Group Assignment

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: second propeller arm scanner
The experimental procedure is to conduct a second helical scanner strictly centered on the heart, 10 minutes after the first helix without inject contrast medium, to assess late enhancement to the inclusion visit.
Radiation: second propeller arm scanner
The experimental procedure is to conduct a second helical scanner strictly centered on the heart, 10 minutes after the first helix without inject contrast medium, to assess late enhancement.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Number of patient with a possible evaluation of myocardial viability using dual-energy cardiac CT
Time Frame: Day 4
To study the sensitivity of dual-energy cardiac CT for the evaluation of myocardial viability, in patients with late presentation myocardial infarction.
Day 4

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Number of patient with a possible evaluation of myocardial viability using cardiac MRI
Time Frame: Day 4
To study the sensitivity of cardiac MRI for the evaluation of myocardial viability in patients with late presentation myocardial infarction.
Day 4

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Rouen

Investigators

  • Principal Investigator: Benjamin DUBOURG, Doctor, University Hospital, Rouen
  • Study Director: Jean-Nicolas DACHER, Professor, University Hospital, Rouen

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 10, 2015

Primary Completion (Actual)

October 7, 2016

Study Completion (Actual)

October 7, 2016

Study Registration Dates

First Submitted

December 15, 2014

First Submitted That Met QC Criteria

February 4, 2015

First Posted (Estimated)

February 10, 2015

Study Record Updates

Last Update Posted (Actual)

April 14, 2026

Last Update Submitted That Met QC Criteria

April 9, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2013/205/HP

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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