Sonographic Evaluation of Diaphragmatic Function in Critical Care Patients With Use of Non Invasive Ventilation (ECHODIA)

Usefulness of non invasive ventilation in patients extubated after more than 48 hours of invasive ventilation is still in debate except for specific patients (chronic pulmonary disease and chronic heart failure).

Many experimental and clinical studies have shown that diaphragmatic function is depressed by mechanical ventilation in intubated patients.

The investigators will test the hypothesis that non invasive ventilation after extubation may improve diaphragmatic function

Study Overview

• Status: Completed
• Conditions: Critical Care; Invasive Mechanical Ventilation
• Intervention / Treatment: Other: Sonographic diaphragmatic measurements

• Study Type: Observational
• Enrollment (Actual): 15

Contacts and Locations

Study Locations

• France
  • Strasbourg, France, 67091
    • Service d'anesthésie- réanimation chirurgicale, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Critical care patients (surgical or medical)

Description

Inclusion Criteria:

• Patient extubated after at least 48 hours of invasive ventilation
• Requiring non invasive ventilation
• Consent of patient

Exclusion Criteria:

• Diaphragmatic paralysis
• Neuromuscular disease
• significant pleural effusion
• atelectasis requiring bronchoscopy
• abdominal hypertension

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Diaphragmatic excursion	Before the first NIV session
Diaphragmatic thickening	Before the first NIV session
Diaphragmatic excursion	After the first NIV session
Diaphragmatic thickening	After the first NIV session
Diaphragmatic excursion	After 24 h of NIV use
Diaphragmatic thickening	After 24 h of NIV use

Collaborators and Investigators

• Sponsor: University Hospital, Strasbourg, France
• Investigators: Principal Investigator: Gharib AJOB, MD, Hôpitaux Universitaires de Strasbourg

Study record dates

Study Major Dates

• Study Start (ACTUAL): June 19, 2015
• Primary Completion (ACTUAL): July 15, 2016
• Study Completion (ACTUAL): July 15, 2016

Study Registration Dates

• First Submitted: February 23, 2015
• First Submitted That Met QC Criteria: February 27, 2015
• First Posted (ESTIMATE): March 5, 2015

Study Record Updates

• Last Update Posted (ACTUAL): March 22, 2018
• Last Update Submitted That Met QC Criteria: March 21, 2018
• Last Verified: March 1, 2018

More Information

Terms related to this study

• Keywords: Non invasive ventilation; Sonography; Diaphragmatic function; Critical care patients; Extubation after 24 hours of invasive ventilation
• Other Study ID Numbers: 5957