Sonographic Measurement of Bladder Wall Thickness in Patients With Neurogenic Bladder Dysfunction

Sonographic Measurement of Bladder Wall Thickness in Patients With Neurogenic Bladder Dysfunction Due to Spinal Cord Injury

Video-urodynamic investigations are regarded as the current standard diagnostics for neurogenic bladder dysfunction in patients with spinal cord injury. This examination is exact, but time consuming, costly and associated with the risk of urinary tract infection.

In patients with lower urinary tract symptoms due to benign prostate hyperplasia, sonographic measurement of bladder wall thickness has been demonstrated to be able to replace urodynamic testing for the diagnosis of infravesical obstruction.

Hypothesis: measurement of bladder wall thickness in patients with neurogenic bladder dysfunction due to spinal cord injury is closely related to the known risk factors for upper urinary tract deterioration (bladder compliance, detrusor leak point pressure) in this group of patients and can therefore replace urodynamic examination in selected cases.

Study Overview

• Status: Completed
• Conditions: Spinal Cord Injury
• Intervention / Treatment: Other: sonographic measurement of bladder wall thickness

• Study Type: Observational
• Enrollment (Actual): 60

Contacts and Locations

Study Locations

• Switzerland
  • Nottwil, Switzerland, 6007
    • Swiss paraplecic centre

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

individuals with neurogenic bladder dysfunction due to spinal cord injury

Description

Inclusion Criteria:

• neurogenic bladder dysfunction due to spinal cord injury
• ability to understand German language
• willingness and capability to undergo urodynamic testing
• age > or = 18 years

Exclusion Criteria:

• acute urinary infection at the time of examination
• known bladder tumor or bladder stone
• age < 18 years
• not capable to understand aim and purpose of the examination

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
one arm; neurogenic bladder dysfunction; evaluation of the clinical utility of bladder wall thickness as a diagnostic tool in patients with spinal cord injury	Other: sonographic measurement of bladder wall thickness; measurement of bladder wall thickness by ultrasound at different filling states of the bladder during urodynamic investigation

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
correlation bladder wall thickness and detrusor compliance	measurement of detrusor compliance at maximum bladder volume; measurement of bladder wall thickness at maximum bladder volume	calculated from maximum bladder filling

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
correlation bladder wall thickness and maximum detrusor pressure	correlation between bladder wall thickness and maximum detrusor pressure during the urodynamic storage phase	measurement at maximum bladder capacity

Collaborators and Investigators

• Sponsor: Swiss Paraplegic Research, Nottwil
• Investigators: Principal Investigator: Juergen Pannek, MD, Swiss Paraplegic Centre

Study record dates

Study Major Dates

• Study Start: August 1, 2009
• Primary Completion (Actual): October 1, 2011
• Study Completion (Actual): October 1, 2011

Study Registration Dates

• First Submitted: December 10, 2010
• First Submitted That Met QC Criteria: February 16, 2011
• First Posted (Estimated): February 18, 2011

Study Record Updates

• Last Update Posted (Actual): February 13, 2024
• Last Update Submitted That Met QC Criteria: February 9, 2024
• Last Verified: February 1, 2024

More Information

Terms related to this study

• Keywords: ultrasound; spinal cord injury; urodynamics; neurogenic bladder dysfunction
• Additional Relevant MeSH Terms: Central Nervous System Diseases; Nervous System Diseases; Urologic Diseases; Urinary Bladder Diseases; Neurologic Manifestations; Wounds and Injuries; Trauma, Nervous System; Spinal Cord Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Spinal Cord Injuries; Urinary Bladder, Neurogenic
• Other Study ID Numbers: 2009-07; EK900 (Registry Identifier: Ethic committee of Lucerne, Switzerland)