Evaluation of the Predictive Nature of the Postoperative CRP on Postoperative Recovery in Patients Undergoing Colorectal Resection (CRP-Track) (CRP-Track)

Evaluation of the Predictive Nature of the Postoperative CRP on Postoperative Recovery in Patients Undergoing Colorectal Resection

Colic and rectal resection represents a majority of hospitalizations in visceral surgery. The objective of this study was to evaluate the prognostic of inflammatory markers dosage (CRP, procalcitonin and venous lactate) on the postoperative recovery after colorectal surgery and on the length of stay.

Study Overview

• Status: Completed
• Conditions: Colorectal Postoperative Complication
• Intervention / Treatment: Other: C-reactive protein dosage

• Study Type: Interventional
• Enrollment (Actual): 176
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • La Roche sur Yon, France, 85925
    • Centre Hospitalier Départemental VENDEE
  • Nantes, France, 44000
    • CHU Nantes

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Upper age to 18 years
• Planned hospital stay for a colonic resection with anastomosis without permanent or temporary digestive bypass
• Patient with pre-operative CRP lower or egal to 172 mg/L
• No opposition at the participation of the study
• Expected patient return home after surgery (or convalescent home or not medicalized institution)

Exclusion Criteria:

• Patient under guardianship
• Protected or private patient freedom
• Minor patient
• Colectomy surgery with digestive bypass or digestive anastomosis
• Complex combined surgery (significantly intestinal resection associated, another surgical procedure that can interfere with postoperative CRP)
• General inflammatory disease susceptive to modify dosage values
• Anti-inflammatory therapy (AINS/ corticosteroids/ immunosuppressive)
• Patient unable to understand the study

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: C-reactive protein dosage	Other: C-reactive protein dosage

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
C-reactive protein rate	The time of postoperative recovery will be compared to the CRP values at 3 postoperative days. The postoperative recovery is a composite endpoint defined by : no pain > 2 on the VAS scale; presence of a gaseous bowel; patient autonomy in terms of ambulation and body care (IRM 5-6); no fever	3 postoperative days

Collaborators and Investigators

• Sponsor: Centre Hospitalier Departemental Vendee
• Investigators: Study Director: Emeric ABET, Centre Hospitalier Départemental VENDEE

Study record dates

Study Major Dates

• Study Start (Actual): July 6, 2015
• Primary Completion (Actual): March 11, 2017
• Study Completion (Actual): June 13, 2017

Study Registration Dates

• First Submitted: March 2, 2015
• First Submitted That Met QC Criteria: March 17, 2015
• First Posted (Estimate): March 23, 2015

Study Record Updates

• Last Update Posted (Actual): June 19, 2017
• Last Update Submitted That Met QC Criteria: June 16, 2017
• Last Verified: June 1, 2017

More Information

Terms related to this study

• Keywords: Postoperative complication; Length of stay; CRP
• Additional Relevant MeSH Terms: Pathologic Processes; Postoperative Complications
• Other Study ID Numbers: CHD 065-14