MDS-CAN: A Prospective National MDS Clinical Database and Local Tissue Bank (MDS)

The purposes of this study are: 1. To identify and quantify the health utilities and quality of life experienced by patients who have been diagnosed with MDS and what are their predictors. 2. Measure the effects of patient related factors like frailty and comorbidity on quality of life and overall survival or toxicity to therapy. 3. Assess how quality of life changes over time and what are its predictors. This will be valuable information that may guide therapy, transfusion practices, etc., as MDS is a chronic, incurable disease that is often progressive.

Study Overview

• Status: Unknown
• Conditions: Myelodysplastic Syndrome (MDS)

Detailed Description

o Participants will be seen and assessed for the study every 6 (+/-1) months. Follow-up for routine clinical care will be dictated by the physician. Clinical information relevant to the MDS diagnosis is entered such as IPSS, IPSS-R, treatments received and responses. Transfusion dependence is recorded. Relevant laboratories such as ferritin, LDH, CBC etc are entered q 6 months. Hospitalizations, bleeding and infections are recorded.

Dates and causes of death are documented Dates of leukaemia transformation are documented. Patients undergoing allogeneic stem cell transplant are documented with date of transplant.

QOL is assessed every 6 months:

QOL instruments are QLQ-C30, QUALMS, EQ-5D and global fatigue scale

Disability, frailty, comorbidity and physical performance is recorded on a yearly basis Disability scale is the Lawton Brody SIADL scale Frailty is measured using the Rockwood clinical frailty scale The comorbidity elements necessary to calculate the Charlson comorbidity scale and the MDS-CI of Della Porta et al. are recorded Physical performance tests are grip strength, 10x stand sit test and the 4 meter walk test

Investigators will continue to enroll new patients throughout this study period of 6 years, but the plan (funding permitting) is to continue this registry indefinitely, with later questions to be addressed.

• Monitoring and auditing data are completed every quarter by a dedicated national registry project manager.
• Monthly data checks are completed to compare data entered into the registry against predefined rules for range or consistency with other data fields in the registry.
• Standard Operating Procedures to address registry operations and analysis activities, such as patient recruitment and data collection has been created and posted electronically in the database for all sites.
• Plan of 25% drop off from death has been assumed due to conversion to AML or non leukemia death and 5% from lost of follow up loss to follow up. This is with the purpose to address situations where variables are reported as missing, unavailable, "non-reported," uninterpreted, or considered missing because of data inconsistency or out-of-range.
• Participant's results will be summarized descriptively as a whole and by province. KM survival curves will be generated and compared using the log-rank test. Univariate and multivariate cox proportional hazard nodel of overall survival will be performed to detect significant association with baseline covariates and time-dependent covariates such as frailty, comorbidity and QOL scores using Statistical Analysis Software (SAS) PHREG procedure.

• Study Type: Observational
• Enrollment (Anticipated): 1200

Contacts and Locations

• Study Contact: Name: Rena Buckstein, MD FRCPC; Phone Number: 5847 416 480 6100; Email: rena.buckstein@sunnybrook.ca
• Study Contact Backup: Name: Martha Lenis, BHA; Phone Number: 85469 416 480 6100; Email: martha.lenis@sunnybrook.ca

Study Locations

• Canada
  • Ontario
    • Toronto, Ontario, Canada, M4N3M5
      • Recruiting
      • Odette Cancer Center
      • Contact: Rena J Buckstein, MD FRCPC; Phone Number: 416-480-5847; Email: rena.buckstein@sunnybrook.ca
      • Contact: Richard Wells, MD FRCPC PhD; Phone Number: 7928 416-480-6100; Email: rwells@sri.utoronto.ca
      • Sub-Investigator: Richard Wells, MD FRCPC PhD
      • Sub-Investigator: Matthew Cheung, MD FRCPC

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 19 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Primary care clinic, referrals from community physicians.

Description

Inclusion Criteria:

• New diagnosis of a Myelodysplastic syndrome
• New diagnosis of CMML-1/CMML-2 and MDS/MPN
• New diagnosis of low blast AML (blasts 20-30%) as defined by the WHO classification (Vardiman, 2002)
• Greater than 18 years of age at the time of diagnosis
• Able to read, write and speak English or French (non-English or French speaking patients may participate if appropriate translation is used)
• Able to consent.

Exclusion Criteria:

• Patients whose diagnostic bone marrow exceed 2 years prior signing consent
• Subjects with AML and bone marrow blast of 31% or more at the time of signing consent
• Prior allogenic cell transplant

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
quality of life	every 6 months up to 6 years

Collaborators and Investigators

• Sponsor: Sunnybrook Health Sciences Centre
• Collaborators: Health Sciences Centre, Winnipeg, Manitoba; The Ottawa Hospital; Jewish General Hospital; Providence Health & Services; Princess Margaret Hospital, Canada; British Columbia Cancer Agency; Royal Victoria Hospital, Canada; Tom Baker Cancer Centre; Vancouver Coastal Health; Juravinski Cancer Center; CancerCare Manitoba; Capital Health, Canada; Réseau de Santé Vitalité Health Network; Saskatoon City Hospital
• Investigators: Study Director: Rena Buckstein, MD FRCPC, Sunnybrook Health Science Centre

Publications and helpful links

General Publications

• Buckstein R, Chodirker L, Mozessohn L, Yee KWL, Geddes M, Zhu N, Shamy A, Leitch HA, Christou G, Banerji V, Brian L, Khalaf D, St-Hilaire E, Finn N, Nevill T, Keating MM, Storring J, Delage R, Parmentier A, Thambipillai A, Siddiqui M, Westcott C, Cameron C, Mamedov A, Spin P, Tang D. A natural history of lower-risk myelodysplastic syndromes with ring sideroblasts: an analysis of the MDS-CAN registry. Leuk Lymphoma. 2022 Dec;63(13):3165-3174. doi: 10.1080/10428194.2022.2109154. Epub 2022 Sep 12.
• Buckstein R, Wells RA, Zhu N, Leitch HA, Nevill TJ, Yee KW, Leber B, Sabloff M, St Hilaire E, Kumar R, Geddes M, Shamy A, Storring J, Kew A, Elemary M, Levitt M, Lenis M, Mamedov A, Zhang L, Rockwood K, Alibhai SM. Patient-related factors independently impact overall survival in patients with myelodysplastic syndromes: an MDS-CAN prospective study. Br J Haematol. 2016 Jul;174(1):88-101. doi: 10.1111/bjh.14033. Epub 2016 Mar 15.

Study record dates

Study Major Dates

• Study Start: August 1, 2005
• Primary Completion (Anticipated): February 1, 2020
• Study Completion (Anticipated): February 1, 2020

Study Registration Dates

• First Submitted: August 19, 2015
• First Submitted That Met QC Criteria: August 28, 2015
• First Posted (Estimate): September 2, 2015

Study Record Updates

• Last Update Posted (Estimate): November 16, 2016
• Last Update Submitted That Met QC Criteria: November 15, 2016
• Last Verified: November 1, 2016

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Neoplasms; Bone Marrow Diseases; Hematologic Diseases; Precancerous Conditions; Myelodysplastic Syndromes; Preleukemia
• Other Study ID Numbers: MDS Database

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: Yes
• IPD Plan Description: Individual participant data can be available to other researchers for their own patients from that center but not other centers. Collective anonymized data of all registry patients is available to them however.