Analysis of B Cells From Autoimmune Individuals

Analysis of B Cells From Autoimmune Individuals

Sponsors

Lead Sponsor: University of Colorado, Denver

Source University of Colorado, Denver
Brief Summary

This observational study aims at finding out if individual with autoimmunity exhibit increased numbers of B cells that express two types (instead of one type) of antibodies, and if B cells of individuals genetically susceptible to autoimmunity display defects in the biological process of tolerance, which removes B cells that participate in autoimmunity.

Detailed Description

Peripheral blood B cells of SLE patients are analyzed by flow cytometry to determine the frequency of B cells co-expressing immunoglobulin kappa an lambda light chains. This frequency is correlated to the disease activity.

Overall Status Recruiting
Start Date May 2016
Completion Date May 2026
Primary Completion Date May 2026
Study Type Observational
Primary Outcome
Measure Time Frame
Frequency of kappa to lambda ratios of B cells in blood of autoimmune adults 1 day
Frequency of CD19 and IgM low B cells in cord blood of babies born from autoimmune mothers 1 day
Enrollment 200
Condition
Eligibility

Sampling Method: Non-Probability Sample

Criteria:

Inclusion Criteria:

- Adult Males and Females diagnosed with Lupus;

- Adult Females who are pregnant and diagnosed with:

- lupus erythematosus

- rheumatoid arthritis, or

- type 1 diabetes.

Exclusion Criteria:

- Adult males or adult females treated with B-cell depletion therapies.

Gender: All

Minimum Age: 18 Years

Maximum Age: 65 Years

Healthy Volunteers: No

Overall Official
Last Name Role Affiliation
Roberta Pelanda, PhD Principal Investigator University of Colorado, Denver
Overall Contact

Last Name: Roberta Pelanda, PhD

Phone: 303-724-8666

Email: [email protected]

Location
Facility: Status: Contact: University of Colorado Roberta Pelanda, PhD 303-724-8666 [email protected]
Location Countries

United States

Verification Date

October 2019

Responsible Party

Type: Sponsor

Has Expanded Access No
Condition Browse
Patient Data Undecided
Study Design Info

Observational Model: Other

Time Perspective: Cross-Sectional

Source: ClinicalTrials.gov