- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02837965
Observational Study Assessing Outcomes, Treatment Patterns and Related Costs in Patients in Bullous Pemphigoid (EDP-PB)
Multicenter Prospective Observational Study Assessing Outcomes, Adverse Events, Treatment Patterns and Related Costs in Patients Diagnosed With Bullous Pemphigoid
Study Overview
Status
Conditions
Detailed Description
Bullous pemphigoid is the most common autoimmune blistering disease of the skin, usually affecting the elderly. It is a chronic disease characterized by spontaneous exacerbations and remissions. Bullous pemphigoid is mediated by IgG autoantibodies directed against hemidesmosomal proteins (BP180, BP230), which are involved in dermal-epidermal adhesion in the skin. The diagnosis of bullous pemphigoid is based on clinical and immunopathological findings, including skin direct immunofluorescence. The disease usually requires on average a 1-year duration of treatment although a long-term maintenance therapy may be necessary some cases. High doses oral corticosteroids have been considered as the mainstay of treatment for many years, but are deleterious, with a high rate of treatment side effects, including mortality. Topical superpotent corticosteroids have been demonstrated to be as effective but safer than high doses of oral corticosteroids, reducing side effects and mortality rate, while controlling the disease in between 95% to 100% of cases. Despite its high efficacy, topical superpotent corticosteroid therapy is often considered as poorly convenient. In addition, immunosuppressant drugs and methotrexate are poorly tolerated or frequently contra-indicated in those elderly patients with bullous pemphigoid. To date, no study has evaluated the real-world use and costs of the different treatments in this disease.
Purpose The project is an observational, multi-center, prospective, non-interventional and open-label data collection study assessing outcomes, adverse events, treatment patterns and related costs in patients diagnosed with bullous pemphigoid. The patient enrollment period will be 1 year with a follow-up (observation period) of 1 year for each patient. Four dermatology centres in France will participate.
Primary objective:
The specific goal is to describe in each patient with bullous pemphigoid the therapeutic management, including: i) all topical and systemic medications and nursing cares; ii) clinical and biological monitoring and iii) clinical outcome during the first year of treatment. The hypothesis to be answered by the study is that topical superpotent corticosteroid therapy is properly used to treat bullous pemphigoid in real-world life as recommended by French guidelines and whether this treatment influences the medical costs by comparison with systemic therapies (e.g. methotrexate or prednisone).
Secondary objectives:
- To determine the factors influencing the first-line therapy : topical superpotent corticosteroid therapy (treatment scheme 1 or TS1) versus systemic therapy (treatment scheme 2 or TS2).
- To determine the factors influencing disease outcome during the first year of treatment, especially TS1 versus TS2.
- To determine total, medical and non-medical costs, during the first year of treatment and to compare these costs between patients treated according TS1 versus TS2.
Exploratory objectives
- To sequentially evaluate several blood biomarkers, including anti-BP180 and anti-BP230 IgG autoantibodies, IL-17, IL-23, IL-12 or other biologic makers and to compare them according the treatment scheme (TS1 versus TS2).
Included patients with bullous pemphigoid will be followed for 1 year. Baseline and 6 follow-up visits are planned to record disease activity, treatment and laboratory monitoring modalities and to collect blood samples for ancillary studies. Clinical data recorded at baseline are gender, age and associated medical conditions (neurological disorders: dementia, stroke, Parkinson's disease, multiple sclerosis; malignancy; other diseases). Baseline clinical evaluation includes the number of daily new blisters for 3 consecutive days, localization of skin or mucous membrane blisters and erosions and BPDAI (bullous pemphigoid disease area index). Extensive bullous pemphigoid is defined as the occurrence of at least 10 new daily blisters. The first-line treatment used will be recorded (superpotent topical CS, i.e. clobetasol propionate cream, 20-30g per day; methotrexate; other systemic therapy). At each visit, the presence of pruritus, erythematous or eczematous or urticarial plaques, and the number of new daily blisters are recorded and a BPDAI (bullous pemphigoid disease area index) is calculated. Topical and systemic treatments for bullous pemphigoid are recorded at each visit, as the occurrence and date of relapse, which eventually occurred. Relapse is defined as the reappearance of ≥3 new daily blisters along with pruritus and/or erythematous, eczematous or urticarial plaques.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Contact
- Name: Philippe Bernard
- Phone Number: 326784488
- Email: pbernard@chu-reims.fr
Study Locations
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Reims, France, 51092
- CHU Reims
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Written informed consent from the patient or a legally authorized representative person.
- Patients affiliated to social security system
- BP newly diagnosed according to the following criteria: i) suggestive clinical features; ii) histological picture of subepidermal blisters with an infiltrate of eosinophils in the superficial dermis; iii) presence of continuous, linear deposits of IgG and C3 deposits along the skin basement membrane zone by direct IF.
- Patients: no prior superpotent topical steroid therapy or systemic treatment for BP for more than 2 weeks
Exclusion Criteria:
- BP in relapse
- Pemphigoid of pregnancy
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
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diagnosed bullous pemphigoid
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
BPDAI (bullous pemphigoid disease area index)
Time Frame: up to one year
|
up to one year
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Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimated)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Skin Diseases
- Immune System Diseases
- Autoimmune Diseases
- Skin Diseases, Vesiculobullous
- Pemphigoid, Bullous
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Anti-Infective Agents
- Nucleic Acid Synthesis Inhibitors
- Enzyme Inhibitors
- Anti-Inflammatory Agents
- Antirheumatic Agents
- Antimetabolites, Antineoplastic
- Antimetabolites
- Antineoplastic Agents
- Immunosuppressive Agents
- Immunologic Factors
- Glucocorticoids
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Antineoplastic Agents, Hormonal
- Dermatologic Agents
- Anti-Bacterial Agents
- Reproductive Control Agents
- Antiprotozoal Agents
- Antiparasitic Agents
- Antimalarials
- Abortifacient Agents, Nonsteroidal
- Abortifacient Agents
- Folic Acid Antagonists
- Prednisone
- Doxycycline
- Methotrexate
Other Study ID Numbers
- PR12042*
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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