- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02864069
Impact of Combined Behavioral Interventions on Cognitive Outcomes in MCI (CBI)
January 7, 2020 updated by: Amy Jak, University of California, San Diego
Vast evidence supports use of physical exercise and cognitive stimulation for lowering risk for cognitive decline and dementia, with combinations of non-pharmacological interventions providing greatest promise for impacting cognitive aging.
This, paired with limited cognitive benefits from pharmacological interventions in dementia, has shifted focus to non-pharmacological interventions administered earlier in the disease course.
This application, therefore, proposes a randomized controlled trial (RCT; 12-week active intervention, 3- and 6-month follow-up) comparing 3 conditions: walking program (guided progressive increases in weekly step counts), computer-based cognitive training program (Brain HQ, Posit Science), and combination of the exercise and cognitive program, on cognitive, functional, and diagnostic outcomes in 60 sedentary, community-dwelling adults with mild cognitive impairment (MCI).
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
52
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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California
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La Jolla, California, United States, 92037
- UCSD
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
60 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- MCI diagnosis (can be self referral, will determine eligibility at baseline)
Exclusion Criteria:
- Dementia diagnosis
- Head trauma
- Neuro/psychiatric disorders
- Current substance dependence
- Sensory/mobility deficits
- No more than 1 hour of purposeful, aerobic activity/week
- Currently engaging in any other brain-stimulating computer program (No more than 1 hour a week)
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Health Services Research
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Walking Intervention
|
The walking intervention will begin following baseline assessments and will be continued for 12 weeks.
Participants will be given a pedometer to use daily and log their daily steps, with an identified goal of increasing step counts by 3000 steps a day over the course of the intervention.
After obtaining a week long baseline step count, individuals in the intervention group will progressively increase their step counts by 100 steps daily each week for the first three weeks, by 200 steps daily for weeks four through six, by 300 steps daily for weeks seven through nine, and by 400 steps daily for weeks ten through twelve.
Mean baseline step counts for sedentary older adults in our pilot work were 4150 per day; therefore, most participants will almost double their daily activity by the end of the intervention.
|
Experimental: Cognitive Training Intervention
|
In the CT condition, participants will use Brain HQ, a computer cognitive training program (Posit Science Corporation, San Francisco, CA), shown to be well tolerated by older adults with positive short- and long-term cognitive outcomes.
Participants will use the program 60 minutes/day, 5 days/week for 12 weeks.
If participants do not have a home computer/internet access, they can complete the modules at another location such as a public library, senior center, or at the MARC, but training will still be self-directed.
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Experimental: Combined Intervention
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The combined condition will concurrently follow both the walking and the CT programs as described above.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Rivermead Behavioral Memory Test
Time Frame: 12 weeks
|
The Rivermead Behavioral Memory Test (RBMT) is an ecologically valid assessment of cognitive functioning that tests some skills specifically trained in the CT condition (e.g., name learning, and story learning) but also additional untrained skills such as prospective memory.
Belongings subtest scaled scores: Minimum score = 1, Maximum score = 19; higher values represent better performance.
|
12 weeks
|
Everyday Cognition Scale
Time Frame: 12 weeks
|
The Everyday Cognition Scale (ECog) assesses (via informant report) everyday cognitive functioning in memory, language, visuospatial, and executive functioning domains.
Average total score was used: Minimum = 1, Maximum = 4, higher scores indicate greater impairment
|
12 weeks
|
Older Peoples Quality of Life Questionnaire
Time Frame: 12 weeks
|
Self report assessment of quality of life specific to older adults.
Assessment covers life overall, health, social relationships and participation, independence, control over life and freedom, home and neighborhood, psychological and emotional well-being, financial circumstances, leisure/activities, and culture and religion.
Total score minimum = 35, max = 175; lower scores indicate better quality of life.
|
12 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Investigators
- Principal Investigator: Amy Jak, Ph.D., University of California, San Diego
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
September 1, 2014
Primary Completion (Actual)
October 1, 2018
Study Completion (Actual)
October 1, 2018
Study Registration Dates
First Submitted
June 27, 2016
First Submitted That Met QC Criteria
August 8, 2016
First Posted (Estimate)
August 11, 2016
Study Record Updates
Last Update Posted (Actual)
January 18, 2020
Last Update Submitted That Met QC Criteria
January 7, 2020
Last Verified
January 1, 2020
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- NPSASA-14-321959
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
YES
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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Clinical Trials on Walking Intervention
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Fox Chase Cancer CenterCompletedCancer of PancreasUnited States
-
Charles University, Czech RepublicBrno University Hospital; University Hospital Olomouc; Tomas Bata Hospital, Czech... and other collaboratorsUnknownDiastolic Heart FailureCzechia
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University of California, Los AngelesCompletedStroke | Hypertension | Sedentary Lifestyle | Aged | Minority GroupsUnited States
-
University of Illinois at ChicagoRecruitingStress, Psychological | Cognitive DeclineUnited States
-
University of the Basque Country (UPV/EHU)Completed
-
Harvard UniversityBlue Cross Blue ShieldCompleted
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University Health Network, TorontoCanadian Institutes of Health Research (CIHR)Not yet recruitingDelirium | Cognitive Impairment | Dementia | Functional Decline
-
Jordi Gol i Gurina FoundationInstituto de Salud Carlos IIINot yet recruiting