- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02884752
Retrospective Study of Bone Infection Due to Campylobacter Spp (CAMPYLO)
Study Overview
Status
Detailed Description
Methods: By browsing the microbiological database of 6 BJI French reference centers, we collected all cases due to Campylobacter species between 2002 and 2012, including first and relapse cases. Clinical, microbiological and treatment features were analyzed using descriptive statistics.
Results: 14 episodes of BJI due to Campylobacter spp were identified in 10 patients. Mean age was 76.8 y.o. (63-96). Sex ratio M/F was 1.5. Nine patient had hip (n=6), knee (n=2), and shoulder (n=2) implants. Immunosuppression was observed in 6 patients (3 cancers, 1 cirrhosis, 1 rheumatoid arthritis, 1 corticosteroid treatment). During the 10 primary cases: all patients had fever and 2 presented digestive symptoms. Campylobacter spp were isolated on per operative samples in 5 patients. One of them presented positive blood culture. 5 patients had joint punctures: all of them were positives. Campylobacter species were C. fetus (n=7), C. coli (n=2) and C. spp (1). Strains were resistant to nalidixic acid (=10), ciprofloxacin (n=4), erythromycin (n=3) or cefotaxime (n=2). Only one C. fetus was susceptible to all antibiotics tested. Surgical treatment was performed in 8 patients (2 two-stage procedure, 6 irrigation). The mean duration of adapted antibiotherapy was 77 days (26-237). 3 out of 4 relapse cases were due to C. fetus. All were resistant to more than one antibiotic classes.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
-
Brest, France, 29609
- CHRU de Brest
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Patient with peroperative bone samples positive to Campylobacter spp. between Jan 2002 and Dec. 2012
- Adults over 18 yo
- No opposition to the study expressed by the patient
Exclusion Criteria:
- Adults below 18 yo
- Spine infection to Campylobacter spp.
- Outside of the timeframe of the study
- No microbiologic data available
- Opposition to the study expressed by the patient
Study Plan
How is the study designed?
Design Details
- Observational Models: Case-Only
- Time Perspectives: Retrospective
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Incidence rate of reported prosthetic joint Campylobacter spp. Infections
Time Frame: 1986 to 2013
|
1986 to 2013
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Séverine Ansart, MD, PHD, CHU Brest
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- CAMPYLO
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Bone Diseases, Infectious
-
Groupe Hospitalier Diaconesses Croix Saint-SimonFondation Ophtalmologique Adolphe de RothschildCompletedArthritis, Infectious | Bone Diseases, InfectiousFrance
-
Debiopharm International SACompletedBone Diseases, InfectiousUnited States
-
Central Hospital, Nancy, FranceEnrolling by invitationInfectious; Spondylitis
-
Universidad Autonoma de Nuevo LeonCompletedSyndrome | Bone Diseases, Infectious | Allografts | Disease of Bone | Spine Infection | Bone Graft; Complications, FractureMexico
-
Murdoch Childrens Research InstituteRecruitingOsteomyelitis | Septic Arthritis | Bone Infection | Bone and Joint InfectionNew Zealand, Australia
-
Rigshospitalet, DenmarkInnovation Fund Denmark; The research foundation of Copenhagen University Hospital... and other collaboratorsActive, not recruitingOsteomyelitis | Septic Arthritis | Bone Infection | Joint Infection | Bone and Joint InfectionDenmark
-
Prof. Dr. Ulrich HeiningerLuzerner KantonsspitalCompletedSeptic Arthritis | Acute Haematogenous OsteomyelitisSwitzerland
-
Xiaojuan LiRecruitingJoint Diseases | Musculoskeletal Diseases | Osteoarthritis | Bone Diseases, Infectious | ACL Tear | Cartilage DegenerationUnited States
-
Medicrea InternationalCompletedSpondylosis | Spinal Neoplasms | Spinal Cord Compression | Ossification of Posterior Longitudinal Ligament | Bone Disease, InfectiousFrance
-
Methodist Health SystemRecruitingOsteomyelitisUnited States