- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02952066
Expressions of TRPV1 in Airway of Asthmatics (TRPV1)
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The research procedure will be conducted at University of Kentucky A.B. Chandler Hospital dedicated bronchoscopy suite located on third floor of Pavilion H module room #2, and will be performed only once as part of a standard of care bronchoscopy procedure scheduled by the participants pulmonary physician. This entire study (biopsy) will add 10 minutes or less. Following the biopsy, and after being discharged from the hospital, the participant's study participation will end.
Bronchial Biopsy: The investigator will collect five lung (bronchial) specimens (1-2 cubic millimeters each) from three zones of the participant's airway which will be individually coded, and stored for the computer image analysis of TRPV1 in the investigator's laboratory. Following analysis the samples will be destroyed. The results of the analysis cannot be used for determining a clinical diagnosis. Therefore, the investigator will not provide any findings to either the participant or their physician.
Participants will not get any personal benefit from taking part in this study. Their willingness to take part in this research study, may, in the future help doctors better understand and/or treat patients with asthma.
There will be no cost to the participant for having the bronchial biopsy performed.
Participants will not receive any rewards or payment for taking part in the study.
Study Type
Phase
- Not Applicable
Contacts and Locations
Study Locations
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Kentucky
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Lexington, Kentucky, United States, 40536
- University of Kentucky Medical Center
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Competent to understand informed consent
- Diagnosis of moderate to severe persistent allergic asthma.
- Clinical need for diagnostic bronchoscopy for assessment of asthmatic symptoms (e.g., to assess presence of chronic infection with non-tuberculous mycobacteria or other infectious agents as a cause for lack of asthma control) or therapeutic bronchoscopy for management of asthmatic symptoms (e.g., thermoplasty).
- Asthmatic subjects with history of positive skin test to confirm presence of allergy.
- Asthmatic subjects with pre-albuterol forced expiratory volume in the first second (FEV1) of <70% of the predicted value.
- Non-asthmatic patients will include those patients with solitary pulmonary nodules and healthy individuals with acute lung atelectasis (e.g. airway blocked by mucus plugs or foreign object).
- Scheduled for a diagnostic or therapeutic bronchoscopy procedure.
Exclusion Criteria:
- Inability to perform pulmonary function testing
- Unstable asthma control for asthmatic subjects
- An asthma exacerbation within the past month
- History of intubation for asthma
- History of smoking
- History of prematurity
- History of any lung disease or disorder except asthma
- History of congenital or acquired heart disease
- Pregnant/lactating females
- Any serious concurrent systemic disease including but not limited to diabetes, coronary artery disease, vasculitis, etc.
- History of heart arrhythmias including supraventricular tachycardia
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: TRP1 Density
Bronchial Biopsy: During the biopsy procedure the investigator will collect five bronchial specimens (1-2 cubic millimeters) each the major, lobar and segmental bronchi.
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Bronchial tissue taken during biopsy
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
TRPV1 density in airway mucosa tissue
Time Frame: one year
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one year
|
Collaborators and Investigators
Sponsor
Investigators
- Study Chair: Lu-Yan Lee, PhD, University of Kentucky
- Principal Investigator: Mehdi Khosravi, MD, University of Kentucky
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 15-0349-F6A
- U01AI123832 (U.S. NIH Grant/Contract)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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