- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03001180
Identification of Biomarkers for Patients With Vascular Anomalies
March 9, 2023 updated by: Children's Hospital Medical Center, Cincinnati
The study will use blood (serum and plasma) and tissue obtained from participants undergoing prescribed surgical resection of vascular anomalies of interest proposed in this study.
The study will also use blood (serum and plasma) and tissue collected and stored in a tissue bank maintained by the Department of Hematology/Oncology.
Study Overview
Status
Recruiting
Detailed Description
While vascular anomalies are rare diseases, they can be life-threatening and devastating to affected children and their families.
Advances in diagnosis, monitoring and therapies will be significantly improved if non-invasive biomarkers that are sensitive and specific can be identified.
Obtaining a tissue biopsy to help in diagnosis can actually worsen the disease and so identification of specific blood biomarkers is highly desirable.
Studies will measure angiogenic factors in serum and plasma samples at baseline and on therapy.
Tissue removed during surgical resection or blood removed prior to sclerotherapy will be used to obtain cells and tissue for the assessment of where biomarkers are coming from and to identify disease-causing pathways for new therapeutic targeting.
Study Type
Observational
Enrollment (Anticipated)
1000
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Timothy LeCras, PhD
- Phone Number: 5138034862
- Email: hvmcresearch@cchmc.org
Study Locations
-
-
Massachusetts
-
Boston, Massachusetts, United States, 02115
- Terminated
- Boston Children's Hospital
-
-
Ohio
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Cincinnati, Ohio, United States, 45229
- Recruiting
- Cincinnati Children's Hospital Medical Center
-
Contact:
- Megan Metcalf
- Phone Number: 513-803-2606
- Email: hvmcresearch@cchmc.org
-
Principal Investigator:
- Timothy LeCras, PhD
-
Sub-Investigator:
- Adrienne Hammill, MD, PhD
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
1 day and older (Child, Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Any participant having labs drawn as standard of care will have blood drawn for the study if consented/assented.
All participants who are undergoing a surgical procedure or sclerotherapy are currently consented for participation in the tissue bank.
The principle investigator will be looking at tissue from these participants.
There is no further recruitment for the study.
Description
Inclusion Criteria:
- Any patient having labs drawn as standard of care will have blood drawn for the study if consented/ assented.
- All patients who are undergoing a surgical procedure or sclerotherapy are currently consented for participation in the tissue bank.
Exclusion Criteria:
- N/A
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Case-Control
- Time Perspectives: Cross-Sectional
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Correlation of Biomarkers with Differential Diagnosis
Time Frame: An Average of Every 2 Years
|
An Average of Every 2 Years
|
Correlation of Biomarkers with Disease Severity
Time Frame: An Average of Every 2 Years
|
An Average of Every 2 Years
|
Correlation of Biomarkers with Response to Therapies
Time Frame: An Average of Every 2 Years
|
An Average of Every 2 Years
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Investigators
- Principal Investigator: Timothy LeCras, PhD, Children's Hospital Medical Center, Cincinnati
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
April 1, 2015
Primary Completion (Anticipated)
December 1, 2050
Study Completion (Anticipated)
December 1, 2050
Study Registration Dates
First Submitted
December 15, 2016
First Submitted That Met QC Criteria
December 20, 2016
First Posted (Estimate)
December 22, 2016
Study Record Updates
Last Update Posted (Actual)
March 13, 2023
Last Update Submitted That Met QC Criteria
March 9, 2023
Last Verified
March 1, 2023
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Cardiovascular Diseases
- Vascular Diseases
- Neoplasms by Histologic Type
- Neoplasms
- Musculoskeletal Diseases
- Bone Diseases
- Cardiovascular Abnormalities
- Hemangioma
- Neoplasms, Vascular Tissue
- Bone Diseases, Developmental
- Angiomatosis
- Bone Resorption
- Osteolysis
- Congenital Abnormalities
- Hemangioendothelioma
- Vascular Malformations
- Osteolysis, Essential
- Klippel-Trenaunay-Weber Syndrome
Other Study ID Numbers
- CCHMC-LMI
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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