Effect of Red Meat Intake on Occurrence of Serum Non-transferrin Bound Iron (NTBI)

January 11, 2017 updated by: Thomas Walczyk
This study aims to evaluate the effect of red meat intake on occurrence of non-transferrin bound iron (NTBI)

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Detailed Description

During Visit 1, blood samples will be collected to assess iron status. During Visit 2, after an overnight fast, participant will be given a standardized meal (rice and potatoes) with a portion of cooked beef (200 g). Blood samples will be collected right before and 2 hour after the meal for NTBI analysis.

NTBI concentration before and after meal consumption will be compared.

Study Type

Interventional

Enrollment (Anticipated)

15

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Singapore
      • Singapore, Singapore
        • National University of Singapore; National University Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

21 years to 45 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • Apparently healthy male volunteers (21 - 45 years old)
  • C-reactive protein (CRP) < 5 mg/L

Exclusion Criteria:

  • Blood donation or significant blood loss (e.g. surgery) within the past 4 months
  • Regular intake of iron and other nutrient supplements within the past 4 months
  • Regular intake of medication except oral contraceptives
  • Acute or recent inflammatory or infectious symptoms
  • Chronic gastrointestinal disorders or metabolic diseases
  • Smoking
  • Coeliac disease or gluten-related disorders
  • Iron deficiency anemia (Hb < 14 g/dL for males) with serum ferritin concentration < 30 ng/mL)
  • Non-iron deficiency anemia (serum ferritin concentration within normal range (30 - 300 ng/mL for males) but low hemoglobin (< 14 g/dL for males)
  • Iron overload conditions (serum ferritin concentration > 300 ng/mL for males)
  • Known hereditary disorders of iron metabolism

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Other: Beef
Beef topside fully cooked, 200g
Other: Beef
200 g beef topside which is fully cooked will be provided to participant after overnight fast. The intervention is one time only.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Occurrence of serum non-transferrin bound iron (NTBI) after consumption of red meat
Time Frame: 2 hour post meal administration
Blood samples collected 2 h after consumption of red meat will be analyzed for non-transferrin bound iron (NTBI) concentration
2 hour post meal administration

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Thomas Walczyk

Investigators

  • Principal Investigator: Thomas Walczyk, Ph.D, National University, Singapore

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 2016

Primary Completion (Anticipated)

March 1, 2017

Study Completion (Anticipated)

March 1, 2017

Study Registration Dates

First Submitted

January 10, 2017

First Submitted That Met QC Criteria

January 11, 2017

First Posted (Estimate)

January 12, 2017

Study Record Updates

Last Update Posted (Estimate)

January 12, 2017

Last Update Submitted That Met QC Criteria

January 11, 2017

Last Verified

January 1, 2017

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 13-441

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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