Absorption and Muscle-stimulating Effect of Hydrolyzed and Minced Beef

To measure the absorption kinetics and postprandial amino acid availability after ingestion of minced beef compared with hydrolyzed beef in young males. Moreover, the basal muscle protein synthesis and the postprandial muscle protein synthetic response to minced beef and hydrolyzed beef ingestion are measured in young males. The postprandial muscle protein synthetic response is measured and compared during the early postprandial period (0-3 hours) after ingestion of the two meat products.

Study Overview

• Status: Unknown
• Conditions: Muscle Protein Synthesis; Meat Protein Supplements; Protein Absorption and Amino Acid Availability
• Intervention / Treatment: Dietary supplement: Minced beef; Dietary supplement: Hydrolyzed beef

• Study Type: Interventional
• Enrollment (Anticipated): 10
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Kasper Dideriksen, PhD; Phone Number: +45 35313948; Email: kasperjuel@hotmail.com
• Study Contact Backup: Name: Lars Holm, PhD; Email: larsh@sund.ku.dk

Study Locations

• Denmark
  • Copenhagen NV, Denmark, 2400
    • Bispebjerg Hospital
    • Principal Investigator: Kasper Dideriksen, PhD
    • Contact: Kasper Dideriksen, PhD; Phone Number: +45 35313948; Email: kasperjuel@hotmail.com
    • Principal Investigator: Søren Reitelseder, PhD
    • Principal Investigator: Lars Holm, PhD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 30 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Healthy
• Non-obese (BMI<30)

Exclusion Criteria:

• Chronic medical disease
• >5 hour of exercise weekly, except light activities such as stretching/gymnastics and bike-riding/walking as transportation

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Health Services Research
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Minced beef	Dietary supplement: Minced beef; Cow meat protein supplement
Experimental: Hydrolyzed beef	Dietary supplement: Hydrolyzed beef; Cow meat protein supplement

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in skeletal muscle protein fractional synthetic rate	The fractional synthetic rate of skeletal muscle proteins (%/h) measured during the overnight fasted state and the postprandial state.	During the postprandial period (0-3 hrs).

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Protein absorption	The change in venous plasma ring-2H5-phenylalanine enrichment after ingestion of meat protein, reflects the protein absorption from the meat protein products.	During the postprandial period (0-3 hrs).
Plasma amino acid concentration	Change in venous plasma amino acid concentration after ingestion of meat protein.	During the postprandial period (0-3 hrs).

Collaborators and Investigators

• Sponsor: Kasper Dideriksen
• Investigators: Principal Investigator: Søren Reitelseder, PhD, Bispebjerg Hospital; Principal Investigator: Kasper Dideriksen, PhD, Bispebjerg Hospital; Principal Investigator: Lars Holm, PhD, Bispebjerg Hospital

Study record dates

Study Major Dates

• Study Start: November 1, 2016
• Primary Completion (Anticipated): March 1, 2018
• Study Completion (Anticipated): March 1, 2018

Study Registration Dates

• First Submitted: March 30, 2016
• First Submitted That Met QC Criteria: April 4, 2016
• First Posted (Estimate): April 8, 2016

Study Record Updates

• Last Update Posted (Estimate): November 8, 2016
• Last Update Submitted That Met QC Criteria: November 7, 2016
• Last Verified: November 1, 2016

More Information

Terms related to this study

• Other Study ID Numbers: H-15012327

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO