Clinical Assessment of Caries and Dental Plaque Based on Auto-fluorescence Imaging System

Clinical Detection and Quantification of Caries and Dental Plaque Based on Auto-fluorescence Imaging System: An Observational Study

The purpose of this study was to evaluate the applicability of auto-fluorescence imaging system to detect and quantify caries and dental plaque. Participants were advised to rinse their mouth with distilled water to exclude any chance of fluorescence from food debris. A well trained physicist majored in optical spectroscopy captured auto-fluorescence images of buccal aspects of two maxillary central incisors and occlusal aspects of four first molars from each patient in a dark room. Then they chewed a disclosing agent to assess the Quigley Hein plaque index modified by Turesky of each tooth. Furthermore, participants were also required to brush their teeth for 3min, then International Caries Detection and Assessment System（ICDAS）codes of relevant teeth to evaluate degrees of caries were recorded by an experienced dentist using a mouth mirror and explorer. The Spearman rank correlation coefficient between colorimetric parameters of fluorescence image and the plaque index and ICDAS code were calculated to evaluate the sensitivity and specificity of auto-fluorescence imaging system.

Study Overview

• Status: Unknown
• Conditions: Dental Plaque; Optical Imaging; Dental Caries (Diagnosis)

• Study Type: Observational
• Enrollment (Anticipated): 60

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 54 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

The study population consisted of 60 patients are from the Affiliated Stomatology Hospital of Medical College, Zhejiang University. They have caries in their mouth and need to be treated by dentists with filling cavity. Two maxillary central incisors and four first molars exist in each patient.

Description

Inclusion Criteria:

Subjects were required to:

• 1. have two maxillary central incisors and four first molars in mouth;
• 2. have caries in their mouth or have a high risk to get caries and need to be treated by dentists ;
• 3. sign informed consent form.

Exclusion Criteria:

• 1.two incisors and four first molars of participants ever received endodontics treatment;
• 2. history of antibiotics, mouthwashes, or any periodontal treatment during the last 3 months;
• 3.with calculus and cementum exposed in tooth cervical;
• 4. active systemic disease;
• 5. physical or mental disability;
• 6. pregnant or lactating.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Auto-fluorescence image assessment	Colorimetric parameters of auto-fluorescence images of buccal aspects of two maxillary central incisors and occlusal aspects of four first molars from each patient were calculated to get the Percentage Plaque Index (PPI). PPI is defined as the ratio between area of dental plaque on teeth and the whole teeth area.	1 week after image collection
The Quigley Hein plaque index modified by Turesky	After disclosing dental plaque, plaque index was evaluated as following scoring system:0 no plaque; separate flecks of plaque at the cervical margin of the margin of the tooth;; a thin continuous band of plaque (up to 1 mm) at the cervical margin;; a band of plaque wider than 1 mm but covering less than (1/3)rd of crown;; plaque covering at least (1/3)rd but less than (2/3)rd of the crown;; plaque covering (2/3)rd or more of the crown	right after disclosing
ICDAS scoring results	After brushing teeth, ICDAS codes were recorded by an experienced dentist using a mouth mirror and explorer:0 sound； first visual change in enamel;; distinct visual change in enamel;; localized enamel breakdown;; underlying dentine shadow;; distinct cavity with visible dentine;; extensive cavity within visible dentine.	right after oral detection

Collaborators and Investigators

• Sponsor: Hui Chen
• Investigators: Study Chair: Hui Chen, Affiliated Hospital of Stomatology, College of Medicine, Zhejiang University

Study record dates

Study Major Dates

• Study Start (Actual): May 1, 2016
• Primary Completion (Anticipated): May 1, 2017
• Study Completion (Anticipated): September 1, 2017

Study Registration Dates

• First Submitted: January 30, 2017
• First Submitted That Met QC Criteria: January 30, 2017
• First Posted (Estimate): January 31, 2017

Study Record Updates

• Last Update Posted (Estimate): January 31, 2017
• Last Update Submitted That Met QC Criteria: January 30, 2017
• Last Verified: January 1, 2017

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Stomatognathic Diseases; Tooth Demineralization; Tooth Diseases; Dental Deposits; Dental Caries; Dental Plaque
• Other Study ID Numbers: DHZhejiangU1

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED