- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03075696
A Dose Escalation Study of Glofitamab (RO7082859) as a Single Agent and in Combination With Obinutuzumab, Administered After a Fixed, Single Pre-Treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma
A Multicenter, Open-Label, Phase I/II Study to Evaluate the Safety, Efficacy, Tolerability and Pharmacokinetics of Escalating Doses of Glofitamab (RO7082859) as a Single Agent and in Combination With Obinutuzumab Administered After a Fixed, Single Dose Pre-Treatment of Obinutuzumab (Gazyva®/Gazyvaro™) in Patients With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Estimated)
Phase
- Phase 2
- Phase 1
Contacts and Locations
Study Contact
- Name: Reference Study ID Number: NP30179 https://forpatients.roche.com/
- Phone Number: 888-662-6728 (U.S. and Canada)
- Email: global-roche-genentech-trials@gene.com
Study Locations
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New South Wales
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Randwick, New South Wales, Australia, 2031
- Recruiting
- Prince of Wales Hospital; Haematology
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Victoria
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Melbourne, Victoria, Australia, 3000
- Recruiting
- Peter MacCallum Cancer Centre
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Bruxelles, Belgium, 1200
- Recruiting
- Cliniques Universitaires St-Luc
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Gent, Belgium, 9000
- Recruiting
- UZ Gent
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Ontario
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Toronto, Ontario, Canada, M5G 1Z5
- Active, not recruiting
- Princess Margaret Cancer Center
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Praha 2, Czechia, 128 08
- Active, not recruiting
- Vseobecna Fakultni Nemocnice v Praze, I. Interni Klinika - Klinika Hematoonkologie VFN a 1. LF UK
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København Ø, Denmark, 2100
- Recruiting
- Rigshospitalet; Hæmatologisk Klinik, Klinisk Afprøvnings Team KAT
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Helsinki, Finland, 00029
- Recruiting
- Helsinki University Central Hospital; Dept of Oncology
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Creteil, France, 94010
- Recruiting
- Hopital Henri Mondor; Hematologie Clinique
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Lille, France, 59037
- Active, not recruiting
- Hopital Claude Huriez; Hematologie
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Montpellier, France, 34295
- Recruiting
- CHU Saint Eloi; Service d'Hématologie Clinique
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Pierre Benite, France, 69495
- Recruiting
- Ch Lyon Sud; Hemato Secteur Jules Courmont
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Rennes, France, 35033
- Recruiting
- CHU DE RENNES - CHU Pontchaillou; Service d'Hématologie Clinique Adulte
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Emilia-Romagna
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Ravenna, Emilia-Romagna, Italy, 48121
- Recruiting
- AUSL della Romagna; Dipartimento Oncoematologico - U.O.C. Oncologia
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Lombardia
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Milano, Lombardia, Italy, 20133
- Recruiting
- Fond. IRCCS Istituto Nazionale Tumori; S. C. Ematologia
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Rozzano, Lombardia, Italy, 20089
- Recruiting
- Istituto Clinico Humanitas;U.O. Oncologia Medica Ed Ematologia
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Piemonte
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Torino, Piemonte, Italy, 10126
- Withdrawn
- A.O.U. Citta' Della Salute E Della Scienza-P.O. Molinette;S.C. Ematologia
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Auckland, New Zealand, 1023
- Active, not recruiting
- Auckland Cancer Trial Centre; Ward 64, Auckland City Hospital,
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Gda?sk, Poland, 80-214
- Active, not recruiting
- Uniwersyteckie Centrum Kliniczne; Osrodek Badan Wczesnych Faz
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Pozna?, Poland, 60-569
- Recruiting
- Uniwersytecki Szpital Kliniczny w Poznaniu; Oddzial Hematologii i Transplantacji Szpiku
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Warszawa, Poland, 02-781
- Withdrawn
- Centrum Onkologii-Instytut im. M. Sklodowskiej-Curie; Oddzial Badan Wczesnych Faz
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Wroc?aw, Poland, 50-367
- Completed
- Uniwersytecki Szpital Kliniczny; Klinika Hematologii, Nowotworów Krwi i Transplantacji Szpiku
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Barcelona, Spain, 08035
- Recruiting
- Hospital Universitari Vall d'Hebron; Servicio de Hematologia
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Barcelona, Spain, 08003
- Recruiting
- Hospital del Mar; Servicio de Hematologia
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Madrid, Spain, 28041
- Active, not recruiting
- Hospital Univ. 12 de Octubre; Servicio de Hematologia
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Barcelona
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Badalona, Barcelona, Spain, 08915
- Active, not recruiting
- Hospital Universitari Germans Trias i Pujol; Servicio de Hematologia
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L'Hospitalet de Llobregat, Barcelona, Spain, 08908
- Active, not recruiting
- Hospital Duran i Reynals L'Hospitalet; Hematology Department
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Cantabria
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Santander, Cantabria, Spain, 39008
- Active, not recruiting
- Hospital Universitario Marques de Valdecilla; Servicio de Hematologia
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Taichung, Taiwan, 404
- Recruiting
- China Medical University Hospital; Oncology and Hematology
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Taipei, Taiwan, 100
- Active, not recruiting
- National Taiwan Universtiy Hospital; Division of Hematology
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California
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Los Angeles, California, United States, 90048
- Withdrawn
- Cedars Sinai Medical Center
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Illinois
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Harvey, Illinois, United States, 60426
- Withdrawn
- Ingalls Memorial Hospital
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Kansas
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Kansas City, Kansas, United States, 66160
- Withdrawn
- University of Kansas Medical Centre
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Michigan
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Ann Arbor, Michigan, United States, 48109-0934
- Active, not recruiting
- University of Michigan
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Missouri
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Saint Louis, Missouri, United States, 63110
- Recruiting
- Washington University; Wash Uni. Sch. Of Med
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New York
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New York, New York, United States, 10029
- Completed
- Mount Sinai Medical Center
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New York, New York, United States, 10065
- Completed
- MSKCC
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Pennsylvania
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Pittsburgh, Pennsylvania, United States, 15212
- Active, not recruiting
- Allegheny Health Network (Pittsburg PA)
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Utah
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Salt Lake City, Utah, United States, 84112
- Withdrawn
- Hunstman Cancer Institute
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Virginia
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Richmond, Virginia, United States, 23230
- Withdrawn
- Virginia Commonwealth University Medical Center
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Washington
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Seattle, Washington, United States, 98104
- Recruiting
- Swedish Cancer Inst.
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Depending upon study part, a history or status of: 1) a histologically-confirmed hematological malignancy that is expected to express cluster of differentiation (CD)20; 2) relapse after or failure to respond to at least one prior treatment regimen; and 3) no available treatment options that are expected to prolong survival (e.g., standard chemotherapy or autologous stem cell transplant [ASCT])
- Measurable disease, defined as at lease one bi-dimensionally measurable nodal lesion, defined as > 1.5 cm in its longest dimension, or at least one bi-dimensionally measureable extranodal lesion, defined as > 1.0 cm in its longest dimension
- Able to provide a fresh biopsy from a safely accessible site, per investigator determination, providing the patient has more than one measurable target lesion
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Life expectancy of >/=12 weeks
- AEs from prior anti-cancer therapy must have resolved to Grade less than or equal to (</=) 1
- Adequate liver, hematological and renal function
- Negative serologic or polymerase chain reaction (PCR) test results for acute or chronic Hepatitis B virus (HBV) infection
- Negative test results for Hepatitis C virus (HCV) and human immunodeficiency virus (HIV)
- Negative serum pregnancy test within 7 days prior to study treatment in women of childbearing potential. Women who are not of childbearing potential who are considered to be post-menopausal (at least 12 months of non-therapy amenorrhea) or surgically sterile (absence of ovaries and/or uterus) are not required to have a pregnancy test
Exclusion Criteria:
- Inability to comply with protocol mandated hospitalizations and restrictions
- Participants with chronic lymphocytic leukemia (CLL), Burkitt lymphoma and lymphoplasmacytic lymphoma
- Participants with a known or suspected history of hemophagocytic lymphohistiocytosis (HLH)
- Participants with acute bacterial, viral, or fungal infection at baseline, confirmed by a positive blood culture within 72 hours prior to obinutuzumab infusion or by clinical judgment in the absence of a positive blood culture
- Participants with known active infection, or reactivation of a latent infection, whether bacterial, viral, fungal, mycobacterial, or other pathogens or any major episode of infection requiring hospitalization or treatment with IV antibiotics within 4 weeks of dosing
- Prior treatment with systemic immunotherapeutic agents, including, but not limited to, radio-immunoconjugates, antibody-drug conjugates, immune/cytokines and monoclonal antibodies (e.g., anti-cytotoxic T-lymphocyte-associated protein 4 [anti-CTLA4], anti-programmed death 1 [anti-PD1] and anti-programmed death ligand 1 [anti-PDL1]) within 4 weeks or five half-lives of the drug, whichever is shorter, before obinutuzumab infusion on Cycle 1 Day -7
- History of treatment-emergent immune-related AEs associated with prior immunotherapeutic agents
- Documented refractoriness to an obinutuzumab-containing regimen
- Treatment with standard radiotherapy, any chemotherapeutic agent, or treatment with any other investigational anti-cancer agent, including chimeric antigen receptor therapy (CAR-T) within 4 weeks prior to obinutuzumab infusion
- Prior solid organ transplantation
- Prior allogeneic SCT
- Autologous SCT within 100 days prior to obinutuzumab infusion
- Participant with history of confirmed progressive multifocal leukoencephalopathy (PML)
- Current or past history of central nervous system (CNS) lymphoma
- Current or past history of CNS disease, such as stroke, epilepsy, CNS vasculitis, or neurodegenerative disease. Participants with a past history of stroke that have not experienced a stroke or transient ischemic attack in the past 2 years and have no residual neurologic deficits are allowed.
- Evidence of significant, uncontrolled concomitant diseases that could affect compliance with the protocol or interpretation of results, including diabetes mellitus, history of relevant pulmonary disorders and known autoimmune diseases
- Participants with another invasive malignancy in the last 2 years (with the exception of basal cell carcinoma and tumors deemed by the Investigator to be of low likelihood for recurrence)
- Significant or extensive history of cardiovascular disease such as New York Heart Association Class III or IV or Objective Class C or D cardiac disease, myocardial infarction within the last 6 months, unstable arrhythmias, or unstable angina
- Administration of a live, attenuated vaccine within 4 weeks before obinutuzumab infusion or anticipation that such a live attenuated vaccine will be required during the study
- Received systemic immunosuppressive medications (including but not limited to cyclophosphamide, azathioprine, methotrexate, thalidomide, and anti-tumor necrosis factor agents) within two weeks prior to obinutuzumab infusion. Treatment with corticosteroid </= 25 mg/day prednisone or equivalent is allowed. Inhaled and topical steroids are permitted.
- Any other diseases, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that would contraindicate the use of an investigational drug
- History of autoimmune disease, including but not limited to myocarditis, pneumonitis, myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus, erythematosus, rheumatoid arthritis, inflammatory bowel disease, vascular thrombosis associated with antiphospholipid syndrome, Wegener's granulomatosis, Sjögren's syndrome, Guillain-Barré syndrome, multiple sclerosis, vasculitis, or glomerulonephritis. Participants with a remote history of, or well controlled autoimmune disease, may be eligible to enroll after consultation with the Medical Monitor
- In Part III DLBCL dexamethasone cohort, patients with a history of hypersensitivity to dexamethasone or systemic corticosteroids will be excluded
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
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Experimental: Part I: Dose Escalation
Participants (single participant cohorts) will receive obinutuzumab (Gpt) 1000 milligrams (mg) single dose IV infusion on Day -7 (pre-treatment) followed by glofitamab IV infusion on Day 1 and Day 8 of Cycle 1. From Cycle 2 onwards, ascending doses of glofitamab will be administered on Day 1 of every 2 week cycle up to Cycle 12 (24 weeks) or until unacceptable toxicity or disease progression.
Glofitamab dosing will be initiated at 5 micrograms (mcg) (flat dose) followed by doses of 15 mcg, 45 mcg, 135 mcg, 405 mcg and 810 mcg.
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Glofitamab will be administered at a dose and as per the schedule specified in the respective arms.
Other Names:
Obinutuzumab 1000 mg single dose IV infusion on Day -7; or 2000 mg single dose administered on Day -7, or split into two 1000 mg doses administered on Days -1 and -7, and per the schedule specified in the respective arms.
Other Names:
Tocilizumab will be administered as an IV infusion, if required, for the management of severe Cytokine Release Syndrome (CRS) occurring during or after any infusion of glofitamab, as per the methods described in the Summary of Product Characteristics (SmPC) or other similar local prescribing documents.
Other Names:
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Experimental: Part II: Dose Escalation
In each treatment regimen, participants will receive obinituzumab (Gpt) 1000 milligrams (mg) IV infusion on Day -7 (pre-treatment); or 2000 mg either administered on Day -7, or split into two 1000 mg doses on Days -1 and -7. The first glofitamab IV infusion will be given on Day 1 of Cycle 1 and a total of 12 cycles will be administered. Monotherapy, glofitamab as a single agent: ascending doses of glofitamab administered on Day 1 of every 2 or 3 week cycle until either the MTD/OBD is defined. Combination Therapy: From Cycle 2 onwards, a fixed dose of 1000 mg obinutuzumab will be administered via IV infusion in combination with ascending doses of glofitamab on Day 1 of every 3 week cycle until either the MTD/OBD is defined. Step-up dosing: Q3W, participants will receive an initial low dose of glofitamab on C1D1, followed by a higher dose on C1D8; the total dose in C1 will not exceed the previously determined MTD. Higher doses may be explored from C2 or later cycles. |
Glofitamab will be administered at a dose and as per the schedule specified in the respective arms.
Other Names:
Obinutuzumab 1000 mg single dose IV infusion on Day -7; or 2000 mg single dose administered on Day -7, or split into two 1000 mg doses administered on Days -1 and -7, and per the schedule specified in the respective arms.
Other Names:
Tocilizumab will be administered as an IV infusion, if required, for the management of severe Cytokine Release Syndrome (CRS) occurring during or after any infusion of glofitamab, as per the methods described in the Summary of Product Characteristics (SmPC) or other similar local prescribing documents.
Other Names:
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Experimental: Part III: Dose Expansion
Part III will start once MTD/OBD is defined. Participants will receive Gpt 1000 mg single dose IV infusion on Day -7 (pre-treatment), followed by glofitamab at a fixed dose regimen or step-up dose regimen on a Q2W or Q3W dosing schedule as determined in Part II. A total of 12 cycles will be administered. Combination Therapy: From Cycle 2 onwards, a fixed dose of 1000 mg obinutuzumab will be administered via IV infusion in combination with glofitamab at the dosing regimen determined in Part II. |
Glofitamab will be administered at a dose and as per the schedule specified in the respective arms.
Other Names:
Obinutuzumab 1000 mg single dose IV infusion on Day -7; or 2000 mg single dose administered on Day -7, or split into two 1000 mg doses administered on Days -1 and -7, and per the schedule specified in the respective arms.
Other Names:
Tocilizumab will be administered as an IV infusion, if required, for the management of severe Cytokine Release Syndrome (CRS) occurring during or after any infusion of glofitamab, as per the methods described in the Summary of Product Characteristics (SmPC) or other similar local prescribing documents.
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
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Part I and II: Percentage of Participants With Dose Limiting Toxicities (DLTs)
Time Frame: From Baseline up to 4 weeks
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From Baseline up to 4 weeks
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Part I, II and III: Percentage of Participants With Adverse Events (AEs)
Time Frame: From Baseline up to 90 days after last dose of study drug or until study completion or participant withdrawal (up to 5 years)
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From Baseline up to 90 days after last dose of study drug or until study completion or participant withdrawal (up to 5 years)
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Part II: MTD or OBD of Glofitamab
Time Frame: From Baseline up to 4 weeks
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From Baseline up to 4 weeks
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Part II: Recommended Phase II Dose (RP2D) of Glofitamab
Time Frame: From Baseline up to 5 years
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From Baseline up to 5 years
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Part III: Complete Response (CR) Rate as Assessed by Independent Review Committee (IRC) According to Standard Non-Hodgkin's Lymphoma (NHL) Response Criteria (Lugano Classification)
Time Frame: From treatment start up to 5 years
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From treatment start up to 5 years
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Part I, II and III: Area Under the Serum Concentration Versus Time Curve (AUC) of Glofitamab
Time Frame: At pre-defined intervals from Cycle 1 Day 1 to Day 71
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At pre-defined intervals from Cycle 1 Day 1 to Day 71
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Part I, II and III: Maximum Serum Concentration (Cmax) of Glofitamab
Time Frame: At pre-defined intervals from Cycle 1 Day 1 to Day 198
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At pre-defined intervals from Cycle 1 Day 1 to Day 198
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Part I, II and III: Minimum Serum Concentration (Cmin) of Glofitamab
Time Frame: At pre-defined intervals from Cycle 1 Day 1 up to Day 198
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At pre-defined intervals from Cycle 1 Day 1 up to Day 198
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Part I, II and III: Clearance (CL) of Glofitamab
Time Frame: At pre-defined intervals from Cycle 1 Day 1 to Day 71
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At pre-defined intervals from Cycle 1 Day 1 to Day 71
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Part I, II and III: Volume of Distribution at Steady-State (Vss) of Glofitamab
Time Frame: At pre-defined intervals from Cycle 1 Day 1 to Day 71
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At pre-defined intervals from Cycle 1 Day 1 to Day 71
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Part I, II and III: Half-Life (t1/2) of Glofitamab
Time Frame: At pre-defined intervals from Cycle 1 Day 1 to Day 71
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At pre-defined intervals from Cycle 1 Day 1 to Day 71
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Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Part I, II and III: Cmax of Obinutuzumab
Time Frame: Pre-dose of obinutuzumab on Day -7; pre-dose (Hr 0) of glofitamab on Day 1 of Cycle 1
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Pre-dose of obinutuzumab on Day -7; pre-dose (Hr 0) of glofitamab on Day 1 of Cycle 1
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Part I, II and III: Cmin of Obinutuzumab
Time Frame: Pre-dose of obinutuzumab on Day -7; pre-dose (Hr 0) of glofitamab on Day 1 of Cycle 1
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Pre-dose of obinutuzumab on Day -7; pre-dose (Hr 0) of glofitamab on Day 1 of Cycle 1
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Part I, II and III: Anti-Drug Antibodies (ADA) to Glofitamab
Time Frame: Pre-dose of obinutuzumab on Day -7; pre-dose (Hr 0) of glofitamab on Day 1 of each cycle from Cycle 2 onwards for a maximum of 8-12 cycles, and at EOT/follow-up visit (up to 5 years)
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Pre-dose of obinutuzumab on Day -7; pre-dose (Hr 0) of glofitamab on Day 1 of each cycle from Cycle 2 onwards for a maximum of 8-12 cycles, and at EOT/follow-up visit (up to 5 years)
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Parts I and II: Percentage of Participants With Overall Response (Partial Response [PR] or Complete Response [CR]) as Determined by the Lugano Classification
Time Frame: From Baseline up to end of study or discontinuation due to disease progression (up to 5 years)
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From Baseline up to end of study or discontinuation due to disease progression (up to 5 years)
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Part I, II and III: Percentage of Participants With PR or CR (Overall Response Rate) as Determined by the Lugano Classifications
Time Frame: From Baseline up to end of study or discontinuation due to disease progression (up to 5 years)
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From Baseline up to end of study or discontinuation due to disease progression (up to 5 years)
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Part I, II and III: Duration of Response (DOR) as Determined by the Lugano Classification
Time Frame: From first occurrence of documented objective response until disease progression, relapse or death due to any cause (up to 5 years)
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From first occurrence of documented objective response until disease progression, relapse or death due to any cause (up to 5 years)
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Part I, II and III: Duration of Complete Response (DOCR) as Determined by the Lugano Classification
Time Frame: From the first occurrence of a documented, complete response, until the time of relapse or death from any cause (up to 5 years)
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From the first occurrence of a documented, complete response, until the time of relapse or death from any cause (up to 5 years)
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Part I, II and III: Progression-Free Survival (PFS) as Determined by the Lugano Classification
Time Frame: From first study treatment to the first occurrence of disease progression or death due to any cause (up to 5 years)
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From first study treatment to the first occurrence of disease progression or death due to any cause (up to 5 years)
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Overall Survival (OS)
Time Frame: From the time of first study treatment to death from any cause (up to 5 years)
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From the time of first study treatment to death from any cause (up to 5 years)
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Time to First Overall Response (TFOR)
Time Frame: From time of treatment start to first documented response (up to 5 years)
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From time of treatment start to first documented response (up to 5 years)
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Time to First Complete Response (TFCR)
Time Frame: From treatment start to first documented complete response (up to 5 years)
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From treatment start to first documented complete response (up to 5 years)
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Health Related Quality of Life (HRQoL) as Assessed by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30)
Time Frame: From baseline through follow-up or until disease progression (up to 5 years)
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From baseline through follow-up or until disease progression (up to 5 years)
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HRQoL as Assessed by the Functional Assessment of Cancer Therapy-Lymphoma (FACT-Lym) Lymphoma Scale
Time Frame: From baseline through follow-up or until disease progression (up to 5 years)
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From baseline through follow-up or until disease progression (up to 5 years)
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Collaborators and Investigators
Sponsor
Investigators
- Study Director: Clinical Trials, Hoffmann-La Roche
Publications and helpful links
General Publications
- Frances N, Bacac M, Bray-French K, Christen F, Hinton H, Husar E, Quackenbush E, Schafer M, Schick E, Vyver AV, Richter WF. Novel in Vivo and in Vitro Pharmacokinetic/Pharmacodynamic-Based Human Starting Dose Selection for Glofitamab. J Pharm Sci. 2022 Apr;111(4):1208-1218. doi: 10.1016/j.xphs.2021.12.019. Epub 2021 Dec 22.
- Broske AE, Korfi K, Belousov A, Wilson S, Ooi CH, Bolen CR, Canamero M, Alcaide EG, James I, Piccione EC, Carlile DJ, Dimier N, Umana P, Bacac M, Weisser M, Dickinson M. Pharmacodynamics and molecular correlates of response to glofitamab in relapsed/refractory non-Hodgkin lymphoma. Blood Adv. 2022 Feb 8;6(3):1025-1037. doi: 10.1182/bloodadvances.2021005954.
- Hutchings M, Morschhauser F, Iacoboni G, Carlo-Stella C, Offner FC, Sureda A, Salles G, Martinez-Lopez J, Crump M, Thomas DN, Morcos PN, Ferlini C, Broske AE, Belousov A, Bacac M, Dimier N, Carlile DJ, Lundberg L, Perez-Callejo D, Umana P, Moore T, Weisser M, Dickinson MJ. Glofitamab, a Novel, Bivalent CD20-Targeting T-Cell-Engaging Bispecific Antibody, Induces Durable Complete Remissions in Relapsed or Refractory B-Cell Lymphoma: A Phase I Trial. J Clin Oncol. 2021 Jun 20;39(18):1959-1970. doi: 10.1200/JCO.20.03175. Epub 2021 Mar 19.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- NP30179
- 2016-001185-28 (EudraCT Number)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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