Elastography in the Diagnosis of Chronic Pancreatitis

Chronic pancreatitis is a progressive inflammatory condition where progressive fibrosis and calcification results in loss of physiological pancreatic function (both endocrine and exocrine). The structural, fibrotic changes of chronic pancreatitis can only be seen in advanced disease with conventional radiology tests and the diagnosis of chronic pancreatitis early in the disease course remains challenging. Early diagnosis and treatment of chronic pancreatitis can prevent the complications of pain and malnutrition and improve the quality of life of patients. Endoscopic ultrasound (EUS) has recently become a favoured method for diagnosing early structural fibrotic changes of chronic pancreatitis in clinical practice; however this technique is subjective with sub-optimal intra-observer agreement. A new technique called elastography, performed during EUS, quantitatively measures tissue stiffness which may give more reliable results. This study aims to assess whether EUS elastography can accurately identify for chronic pancreatitis.

Patients referred for EUS examinations will be identified and recruited prospectively. The investigators will perform endoscopic ultrasound examinations with elastography readings in two groups of patients: those referred for EUS with suspicion of chronic pancreatitis and those referred for EUS for assessment of abdominal pain without risk factors or any other tests suggesting chronic pancreatitis. The elastography readings will then be compared to the gold standard which is a composite evaluation including standard EUS examination using morphological appearance (Rosemont classification), and other tests already performed including cross-sectional imaging (MRCP and CT), patient history and faecal pancreatic elastase (FEL-1).

Patients will be identified and data collected prospectively. There is no randomization or blinding involved in the study as the endoscopists will need to be aware of the indication for referral in order to carry out a complete examination.

Study Overview

• Status: Completed
• Conditions: Pancreatitis, Chronic
• Intervention / Treatment: Procedure: Endoscopic ultrasound elastography

Detailed Description

Chronic pancreatitis is a chronic inflammatory condition where progressive fibrosis and scarring leads to loss of pancreatic exocrine and endocrine function and can lead to development of malnutrition, weight loss, abdominal pain and impaired quality of life. Patients with chronic pancreatitis have a high risk of pancreatic adenocarcinoma compared to the general population so it is vital that they are identified early in the disease. There are numerous causes of chronic pancreatitis therefore early detection and treatment can prevent irreversible changes and symptoms developing.

Trans-abdominal ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI) are currently used to investigate patients with symptoms suggestive of chronic pancreatitis. These tests may, however, fail to show early changes in the bile ducts or small areas of inflammation in pancreatic tissue. In areas of diagnostic uncertainty, endoscopic ultrasound (EUS) is currently used to provide a more detailed assessment.

EUS uses a flexible endoscope (similar to a gastroscope) passed into the stomach via the mouth. The EUS scope has the addition of a tiny ultrasound probe on the tip which is used to acquire high resolution detailed images of the pancreas and other extra luminal structures (lymph nodes, bile ducts, mediastinum) lying only centimeters from the tip of the probe. Despite the advantages of EUS, image interpretation can be extremely challenging and in the presence of inflammation. Morphological changes of chronic pancreatitis seen at EUS have been classified according to the Rosemont classification; however, the findings are subjective with sub-optimal intra-observer agreement.

Elastography is an ultrasound technique used to assess stiffness of tissues in the body. It has established applications in detecting chronic liver disease, and improving diagnostic accuracy in breast and prostate cancers. Pancreatic elastography is now able to be performed during a standard EUS examination using the existing equipment (in a similar manner to Doppler). Tissue elasticity is measured and represented with different colours (on a scale of 1 to 255). The colour signal (red-green-blue) is then superimposed on the conventional grey-scale image. Areas of increased stiffness are marked with dark blue, intermediate areas with green and soft tissue areas with red. Areas of interest are able to be marked to give an elasticity reading and this is also compared to a control area of stomach wall to calculate a ratio (strain ratio).

Elastography has now become part of the routine EUS exam following several studies that have shown elastography can be successfully used to identify malignant pancreatic and lymph node masses with high sensitivity allowing accurate targeting of fine needle aspiration (FNA) biopsies and early confirmation or exclusion of cancer.

The investigators hypothesise that changes of chronic pancreatitis can also be detected using elastography assisted EUS. Detecting change at an early stage will benefit patients and potentially reduce complications that result from chronic pancreatitis such as malnutrition, pain and osteoporosis.

• Study Type: Interventional
• Enrollment (Actual): 38
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United Kingdom
  • South Yorkshire
    • Sheffield, South Yorkshire, United Kingdom, S10 2JF
      • Sheffield Teaching Hospitals NHS FT

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 14 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Age 18 or over,
• Patients referred for EUS for investigation of abdominal pain without a cause found on assessment with MRI and FEL-1.
• Patients referred for EUS for chronic pancreatitis assessment based on MRI and/or FEL-1 testing.

Exclusion Criteria:

• Patients with known solid pancreatic lesions
• Patients under the age of 18
• Patients who decline EUS examination
• Patients referred for EUS with indications other than epigastric pain or suspicion of chronic pancreatitis

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: suspected chronic pancreatitis patients; Patients with suspected chronic pancreatitis will undergo Endoscopic ultrasound elastography to assess whether this detects chronic pancreatitis.	Procedure: Endoscopic ultrasound elastography; Endoscopic ultrasound elastography performed on both groups of patients as per routine
Other: Assessment of abdominal pain patients; Patients who are referred for assessment of abdominal pain without risk factors or any other tests suggesting chronic pancreatitis will undergo Endoscopic ultrasound elastography	Procedure: Endoscopic ultrasound elastography; Endoscopic ultrasound elastography performed on both groups of patients as per routine

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Elastography strain ratios	The primary outcome measure for this study will be Elastography strain ratios in patients found to have changes consistent with chronic pancreatitis on conventional EUS Rosemont criteria or other investigations and those without	through study completion which will be a maximum of one hour

Collaborators and Investigators

• Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust
• Investigators: Principal Investigator: Jennifer Campbell, Sheffield Teaching Hospitals NHS FT

Study record dates

Study Major Dates

• Study Start (Actual): November 29, 2016
• Primary Completion (Actual): November 29, 2019
• Study Completion (Actual): November 29, 2019

Study Registration Dates

• First Submitted: May 24, 2017
• First Submitted That Met QC Criteria: May 30, 2017
• First Posted (Actual): June 1, 2017

Study Record Updates

• Last Update Posted (Actual): April 24, 2024
• Last Update Submitted That Met QC Criteria: April 23, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Digestive System Diseases; Pathologic Processes; Disease Attributes; Pancreatic Diseases; Chronic Disease; Pancreatitis; Pancreatitis, Chronic
• Other Study ID Numbers: STH19471

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: no IPD sharing will occur

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No