Predicting Dropout and Outcome From Neuropsychological Functions in SUD Patients

Predicting Early Treatment Termination (Dropout) and Post-treatment Clinical Outcome From Neuropsychological Functions in Abstinent Substance Use Dependent (SUD) Patients

The aim of this project is to gain a more specific understanding of how different cognitive profiles predict residential treatment drop-out, treatment retention and post-treatment outcome in a population with Substance Use Disorder.

Study Overview

• Status: Active, not recruiting
• Conditions: Substance Use Disorder (SUD)

Detailed Description

This project collects the neuropsychological profile of residential SUD patients, in addition to treatment length, exit reason, hospital journal data and post-treatment clinical outcome data. The project aims to identify clinically relevant neurocognitive domains that predict treatment dropout and post-treatment clinical outcome. This will make it possible for future clinicians to focus their effort on neurocognitive functions most relevant for this particular patient group.

RESEARCH QUESTIONS:

1. What neurocognitive domain (and sub-domain) are the strongest predictor of treatment drop-out and retention?
2. What neurocognitive domain (and sub-domain) are the strongest predictor of post-treatment clinical outcome variables such as drug use, health and social integration.
3. Will data on treatment length, age, gender, substance abuse history or psychiatric co-morbidity predict outcome independently, or in interaction with, the neuropsychological profile?

This longitudinal prospective cohort study aims for a continuous collection of neuropsychological data baseline and post-treatment follow-up data until 2030.

• Study Type: Observational
• Enrollment (Estimated): 200

Contacts and Locations

Study Locations

• Norway
  • Oslo, Norway, 0320
    • Oslo University Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 16 years to 78 years (Adult, Older Adult)
• Accepts Healthy Volunteers: N/A

• Sampling Method: Non-Probability Sample

Study Population

Treatment seeking Substance Use Disorder (SUD) patients.

Description

Inclusion Criteria:

• Substance Use Disorder (SUD) patients.
• 18 years or older.
• Qualified to consent to research participation.
• Able to speak and write in Norwegian.

Exclusion Criteria:

• Not qualified to consent to research participation.
• Insufficient understanding of Norwegian.

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Exit reason	Reason for terminating residential SUD treatment (Treatment completed or Drop-out)	On average 3 months
Treatment retention	Number of days in treatment	On average 3 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Substance use	DUDIT (Drug Use Disorders Identification Test)	1 year after neuropsychological assessment
Psychological distress	SCL-10 (Symptom Checklist)	1 year after neuropsychological assessment
Quality of Life	QoL-5 (Quality of Life)	1 year after neuropsychological assessment
ADHD symptoms	ASRS (ADHD Self-Report Scale)	1 year after neuropsychological assessment
Income	Nature of income	1 year after neuropsychological assessment
Housing	Nature of present accommodation	1 year after neuropsychological assessment

Collaborators and Investigators

• Sponsor: Oslo University Hospital
• Investigators: Principal Investigator: Espen Walderhaug, PhD, Oslo University Hospital

Study record dates

Study Major Dates

• Study Start (Actual): March 7, 2017
• Primary Completion (Estimated): December 31, 2029
• Study Completion (Estimated): December 31, 2029

Study Registration Dates

• First Submitted: March 8, 2017
• First Submitted That Met QC Criteria: July 16, 2017
• First Posted (Actual): July 18, 2017

Study Record Updates

• Last Update Posted (Actual): January 5, 2024
• Last Update Submitted That Met QC Criteria: January 3, 2024
• Last Verified: January 1, 2024

More Information

Terms related to this study

• Keywords: Cognition; Follow-up; Neuropsychology; Drop-out
• Additional Relevant MeSH Terms: Mental Disorders; Chemically-Induced Disorders; Substance-Related Disorders
• Other Study ID Numbers: 2015/11288

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No