Effects and Mechanism of Two Hybrid Exercise-cognitive Trainings in Mild Ischemic Stroke With Cognitive Decline

Effects and Mechanism of Two Hybrid Exercise-cognitive Trainings in Mild Ischemic Stroke With Cognitive Decline: fMRI for Brain Plasticity, and Biomarker and Behavioral Analysis

The purposes are to: (1) examine and compare the effects of two hybrid interventions on brain plasticity, physiological biomarkers and behavioral outcomes, including cognitive and physical functions, from pre- to post-training; (2) understand the neural mechanisms of cognitive recovery following two hybrid interventions using the functional magnetic resonance imaging (fMRI); (3) examine the long-term benefits of the two hybrid therapies; (4) to identify the correlations between brain activity, biomarkers and behavioral measures.

Study Overview

• Status: Completed
• Conditions: Stroke Patients With Cognitive Decline
• Intervention / Treatment: Behavioral: Sequential training; Behavioral: Dual training; Behavioral: Control training

Detailed Description

Cognitive decline after stroke is highly associated with functional disability. Empirical evidence shows that exercise combined cognitive training may induce neuroplastic changes that modulate cognitive function. However, it is unclear whether hybridized exercise-cognitive trainings can facilitate cortical activity and physiological outcome measures and further influence on the cognitive function after stroke. We aim to investigate the effects of two hybridized exercise-cognitive trainings on brain plasticity, physiological biomarkers and behavioral outcomes in stroke survivors with cognitive decline. This study is a single-blind randomized controlled trial. A target sample size of 75 participants will be recruited. Stroke survivors with mild cognitive decline will be stratified by Mini-Mental State Examination scores and then randomized 1:1:1 to sequential exercise-cognitive training, dual-task exercise-cognitive training or control groups. All groups will undergo trainings 60 min/day, 3 days/week, for a total of 12 weeks. The primary outcome is the resting-state functional connectivity and neural activation in the frontal, parietal and occipital lobes in functional magnetic resonance imaging. Secondary outcomes include physiological biomarkers, cognitive functions, physical function, daily functions and quality of life.

This study may differentiate the effects of two hybridized trainings on cognitive function and health-related conditions and detect appropriate neurological and physiological indices to predict training effects. This study capitalizes on the groundwork for non-pharmacological intervention of cognitive decline after stroke.

• Study Type: Interventional
• Enrollment (Actual): 44
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Taiwan
  • Kaohsiung, Taiwan, 812
    • Kaohsiung Municipal Siaogang Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

1. Stroke occurring at least 6 months prior to enrollment
2. Age range from 20 to 80 years
3. MMSE score < 28 or MoCA<25
4. Able to follow the study instruction
5. Adequate cardiopulmonary function to perform aerobic exercise
6. Able to walk with or without assistive devices

Exclusion Criteria:

1. Unstable medical history (e.g., recent myocardial infarction) that might limit participation
2. Concomitant with other neurological disorders (e.g., Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis)
3. Current participation in another interventional trial
4. Any contraindication to MRI (metallic implants, claustrophobia, seizure, pacemakers, et al)
5. Pregnant woman

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Sequential training group; Exercise training for 30 minutes followed by 30 minutes of cognitive-based intervention	Behavioral: Sequential training; The participant will cycle on a stationary bike for 30 minutes, which includes a 3-min warm-up phase followed by the aerobic training components (25 minutes), then a 2-min cool-down phase. The target heart rate during the aerobic training phase will be 40 to 70% of maximal heart rate (HRmax). After cycling, the participant will engage in a 30-minute of computer-based cognitive training program using BrainHQ (Posit Science Inc., San Francisco, CA, USA). The following are the areas of training: visuospatial processing, attention, memory, language, and logical thinking.
Experimental: Dual training group; Exercise training simultaneously combined cognitive-based intervention for 60 minutes	Behavioral: Dual training; The dual-task training group will cycling concurrently with the computer-based cognitive training. The training principle of cycling and cognitive training is similar to the SEQ group; however, the training intensity will be adjusted according to each participant's ability.
Active Comparator: Control training group; non-aerobic exercise (e.g., stretch, range of motion exercise...) and unstructured cognitive rehabilitation programs (e.g., reading newspapers, playing board games...) for 60 minutes	Behavioral: Control training; The control participants will receive 60 minutes of health-related rehabilitation programs which involves non-aerobic physical exercise (e.g., muscle stretching, range of motion exercises, relaxation techniques) and unstructured cognitive related rehabilitation programs (e.g., watch health-related videos or read newspapers or magazines and then answer the content-related questions raised by the therapist).

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
fMRI (change is being assessed)	Resting-state functional connectivity and neural activation in the frontal, parietal and occipital lobes	Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months).

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Serum BDNF level	Up-regulation of neurotrophic and vascular growth factors	Baseline, posttest (an expected average of 3 months)
Antioxidative marker	Antioxidative markers will be used to reflect the changes on oxidative stress. In particular, we will be analyzing the total antioxidant capacity (TAC).	Baseline, posttest (an expected average of 3 months)]
Glucose indicator	HbA1C level will be tested to investigate the relationships between blood glucose level and aerobic exercise	Baseline, posttest (an expected average of 3 months)
Plasma lipid level	The cholesterol ratio (total cholesterol divided by high-density lipid) will be evaluated to reflect the lipid level in the blood	Baseline, posttest (an expected average of 3 months)
Montreal Cognitive Assessment (MoCA)	The MoCA will be used to assess general cognitive functions. It examines several cognitive domains with a total score of 30	Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months)
Wechsler Memory Scale - Third Edition (WMS-III)	The WMS-III is a standardized and reliable neuropsychological examination tool designed to evaluate visuospatial and memory functions	Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months)
Wechsler Adult Intelligence Scale - Third Edition (WAIS-III)	The WAIS-III is developed to measure an individual's intelligence level. It includes tests that evaluate cognitive functions in verbal comprehension, working memory, perceptual organization, and processing speed	Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months)
Useful Field of View (UFOV)	The UFOV assessment is a computer-based visual test containing three subtests: visuomotor processing speed, divided attention, and selective attention.	Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months)
Stroop Color-Word test	The Stroop Color-Word assesses the abilities of selective attention, inhibition and executive function. The participants will be tested under congruent and incongruent conditions.	Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months)
Dual-task test	The dual-task test evaluates the ability to shift attention between one task and another. Participants will perform the box and block test (BBT) while doing secondary cognitive tasks while sitting. Participants will perform BBT by affected and less affected hand.	Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months)
Time up and go test (TUG)	The TUG assesses the dynamic balance ability and mobility. The participants will be required to stand up from a chair, walk 3 meters, turn around, walk back to the chair, and sit down.	Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months)
Six-minute walk test (6MWT)	The 6MWT measures the maximum distance walked over 6 minutes, which assess the endurance and mobility level of the participants. The participants could rest as needed during the course of the test.	Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months)
International Physical Activity Questionnaires (IPAQ)	The IPAQ is an international measure of health-related physical activity.	Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months)
Fugl-Meyer Assessment (FMA)	The 33-item upper limb subscale of the FMA will be used to assess motor impairments.	Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months)
Rivermead Mobility Index (RMI)	The RMI evaluates the participant's bed mobility, postural transfers and walking ability. It contains a 15-item scale which includes 14 questions and one direct observation, with a total of score of 15.	Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months)
Muscle strength	Accelerometers will be used to provide an objective measure of the amount of arm movements in real-life situations. The participants will be asked to wear an Actigraphy activity monitor.	Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months)
Mobility level	Accelerometers will be used to provide an objective measure of the amount of arm movements in real-life situations. The participants will be asked to wear an Actigraphy activity monitor.	Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months)
Functional Independence Measure (FIM)	The FIM assesses the dependence level of individuals with stroke to perform 18 activities (13 motor and five cognitive tasks) in daily living. The score ranges from 18 to 126 and higher scores demonstrate greater independent participation in daily activities.	Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months)
Lawton Instrumental Activities of Daily Living Scale (Lawton LADL)	The Lawton IADL scale assesses independent living skills, such as shopping or managing finances.	Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months)
Stroke Impact Scale (SIS)	The SIS 3.0 will be used to evaluate health-related quality of life for patients with stroke. The SIS assesses eight domains (strength, hand function, ADL/IADL, mobility, communication, emotion, memory and thinking, and participation/role function) with 59 test items.	Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months)
Caregiver Burden Scale (CB scale)	B scale evaluates the burden of the primary caregiver of the participants. Lessening the burden of caregivers after the intervention may significantly improve the quality of life for patients with stroke and their family.	Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months)
EuroQol-5D questionnaire (EQ-5D)	The quality of life will be assessed by the EQ-5D questionnaire which comprises the following five dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression.	Baseline, posttest (an expected average of 3 months), follow-up (up to 9 months)

Collaborators and Investigators

• Sponsor: Chang Gung Memorial Hospital
• Investigators: Principal Investigator: Ching-yi Wu, ScD, Chang Gung University

Publications and helpful links

General Publications

• Gibson E, Koh CL, Eames S, Bennett S, Scott AM, Hoffmann TC. Occupational therapy for cognitive impairment in stroke patients. Cochrane Database Syst Rev. 2022 Mar 29;3(3):CD006430. doi: 10.1002/14651858.CD006430.pub3.

Study record dates

Study Major Dates

• Study Start (Actual): April 19, 2018
• Primary Completion (Actual): July 3, 2020
• Study Completion (Actual): July 31, 2020

Study Registration Dates

• First Submitted: July 18, 2017
• First Submitted That Met QC Criteria: July 25, 2017
• First Posted (Actual): July 26, 2017

Study Record Updates

• Last Update Posted (Actual): October 26, 2020
• Last Update Submitted That Met QC Criteria: October 22, 2020
• Last Verified: September 1, 2020

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Cardiovascular Diseases; Vascular Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Cognition Disorders; Stroke; Ischemic Stroke; Cognitive Dysfunction
• Other Study ID Numbers: KMUHIRB-F(II)-20170040

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No