EEG Monitoring for PERFormance Anticipation (MEEGAPERF)

September 30, 2025 updated by: Hospices Civils de Lyon

Electrophysiological and Bioenergetic Study of Variations in Cognitive and Physical Performance in Healthy Humans: EEG Monitoring for PERFormance Anticipation

Identify, characterize and then validate electrophysiological markers linking electrophysiological cerebral activity and performance in cognitive and physical fatigability in humans. To do this, noninvasive explorations of electroencephalography (EEG) and magnetoencephalography (MEG) will be carried out under two conditions of different experiments, the first one that induces a cognitive fatigability and the second one that induces physical fatigability.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

169

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Bron, France, 69500
        • Hospices Civils de Lyon, HFME

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 70 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria MGPFco group:

  • Adult subjects, male or female, right-handed or left-handed, from 18 years up to 70 years;
  • Having duly completed the entire confidential medical questionnaire;
  • Written consent of free, informed and express participation;
  • No hearing problems;
  • Having normal or corrected vision;
  • Affiliation to a Social Security scheme.

Inclusion Criteria MGPFph group:

  • Adult subjects, male or female, right-handed or left-handed, from 18 years up to 35 years;
  • Practicing at least five hours of sports per week;
  • Presenting a certificate of no contraindication to an exercise test, intense sports practice or an energy sport in competition of the current year;
  • Having duly completed the entire confidential medical questionnaire;
  • Without cardiovascular or motor disability;
  • Without tumoral, inflammatory, cardiac, pulmonary, renal, digestive (malabsorption syndrome) or liver disease;
  • Written consent of free, informed and express participation;
  • Affiliation to a Social Security scheme.

Exclusion Criteria:

  • Pregnant women, nursing mothers or those of childbearing age without contraception
  • Persons under guardianship, curatorship or any other administrative or judicial measure of deprivation of liberty or of liberty
  • Persons protected by the law
  • Persons who have performed a maximum stress test within 15 days of the date of inclusion,
  • In the course of drug treatments against indicated for the protocol (treatment for neurological diseases, psychiatric ...).
  • Metal implants incompatible with MRI (for the subjects concerned, see appendices)
  • Metallic implants incompatible with the MEG (for the subjects concerned, see appendices)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Non-Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Other: Cognitive Fatigability
Other: Electroencephalography (EEG) multi-sensor
Electrophysiological measurements of cerebral activity will be performed by multi-sensor electroencephalography (EEG), which is a non-invasive method.
Other: Magnetoencephalography (MEG)
Electrophysiological measurements of brain activity will be performed by magnetoencephalography (MEG) which is a non-invasive method.
Other: Behavioral Measures
The evaluation of cognitive performance will be carried out by means of behavioral measures, push-button type, handling of a mouse or a joystick.
Other: Reaction time measurement
The assessment of cognitive performance will be carried out using standard behavioral measures, such as reaction time measurement.
Other: Assessment of physical performance
The assessment of physical performance will be based both on bioenergetic measurements and on quantitative data collected in continuous and relative to the effort (eg instantaneous pedaling speed).
Other: Electrooculogram (EOG)
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
Other: Electromyogram (EMG)
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
Other: Electrocardiogram with 3 leads
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
Other: Physical Fatigability
Other: Electroencephalography (EEG) multi-sensor
Electrophysiological measurements of cerebral activity will be performed by multi-sensor electroencephalography (EEG), which is a non-invasive method.
Other: Magnetoencephalography (MEG)
Electrophysiological measurements of brain activity will be performed by magnetoencephalography (MEG) which is a non-invasive method.
Other: Behavioral Measures
The evaluation of cognitive performance will be carried out by means of behavioral measures, push-button type, handling of a mouse or a joystick.
Other: Reaction time measurement
The assessment of cognitive performance will be carried out using standard behavioral measures, such as reaction time measurement.
Other: Assessment of physical performance
The assessment of physical performance will be based both on bioenergetic measurements and on quantitative data collected in continuous and relative to the effort (eg instantaneous pedaling speed).
Other: Electrooculogram (EOG)
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
Other: Electromyogram (EMG)
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
Other: Electrocardiogram with 3 leads
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
Other: Electrodermogram (EDG)
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
Other: Consumption of O2 (VO2)
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
Other: Production of CO2 (VCO2)
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Identify electrophysiological markers in humans depending on whether the experimental conditions induce cognitive fatigability.
Time Frame: 7 hours
The evaluation of cognitive performance will be carried out by means of conventional behavioral measures, of the press-button type, handling of a mouse or of a joystick and measurement of reaction time.
7 hours
Identify electrophysiological markers in humans depending on whether the experimental conditions induce physical fatigability with EEG.
Time Frame: 7 hours
Electrophysiological measurements of cerebral activity will be performed by multi-sensor electroencephalography (EEG).
7 hours
Identify electrophysiological markers in humans depending on whether the experimental conditions induce physical fatigability with MEG.
Time Frame: 7 hours
Electrophysiological measurements of cerebral activity will be carried out by magnetoencephalography (MEG)
7 hours

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Refine (locate at the level of the cortex), the origin of these physiological markers
Time Frame: 7 hours

Several types of recordings, passive and non-invasive, will be realized:

  • Electrooculogram (EOG);
  • electromyography (EMG);
  • electrocardiogram (ECG); Systematically in "physical" experiments and for some "cognitive" experiments.
7 hours
Distinguish between different time scales of performance
Time Frame: 7 hours

Several types of recordings, passive and non-invasive, will be realized:

  • electrodermogram (EDG);
  • the consumption of O2 (VO2);
  • production of CO2 (VCO2). Only and systematically, in "physical" experiments.
7 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Hospices Civils de Lyon

Investigators

  • Principal Investigator: Julien JUNG, MD, Hospices Civils de Lyon

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 30, 2013

Primary Completion (Actual)

May 31, 2018

Study Completion (Actual)

May 31, 2018

Study Registration Dates

First Submitted

April 25, 2017

First Submitted That Met QC Criteria

July 25, 2017

First Posted (Actual)

July 28, 2017

Study Record Updates

Last Update Posted (Estimated)

October 3, 2025

Last Update Submitted That Met QC Criteria

September 30, 2025

Last Verified

September 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 69HCL16_0661

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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