- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03271775
Vestibulopathy With Vestibulo Ocular Reflex (VOR) Gain Deficit (VOR)
August 31, 2017 updated by: Carmeli Eli, University of Haifa
Vestibulopathy With Vestibulo Ocular Reflex (VOR) Gain Deficit - Characteristics of Overt and Covert Saccadic Eye Movements Measured by the Video Head Impulse Test (vHIT)
The study is examine the eye movements characteristics of patients with VOR gain deficits (overt and covert saccades) before and after physical therapy intervention program and examine the most effective physical therapy treatment program for patients with vestibulopathy.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Detailed Description
The vestibular system receives and conveys information about head motion in space, and is the main human sensory system dedicated to detecting self-motion.The vestibular system plays a crucial role in static and dynamic balance control, stabilizing the head and trunk, especially on unstable surfaces .
In terms of postural control and falls, the literature describes a direct association between VOR deficits, gait instability, and falls.The "gain" of the VOR is defined as the change in the eye angle divided by the change in the head angle during the head turn.
Under ideal conditions, the gain of the rotational VOR is 1.0, meaning there is a compensatory eye velocity equal to the head velocity and in the opposite direction.
In case of a positive vHIT, the VOR gain is decreased and refixating saccades are observed.
The video Head Impulse Test measures eye velocity during head rotation.
Instant feedback about every single head impulse allows the examiner to apply a set of standardized graded impulses.
The system is easy to use in a clinical setting, provides an objective measure of the VOR, and detects both overt and covert catch-up saccades in patients with vestibular loss.
Measurements are quick and noninvasive, and the automated analysis software provides instant results.
Study Type
Interventional
Enrollment (Anticipated)
100
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Liraz Tencer-Lagziel, MA
- Phone Number: +972-9-7440429
- Email: liraztencer@gmail.com
Study Contact Backup
- Name: Oz Zur, PHD
- Phone Number: +972-9-7440429
- Email: zurbalance@gmail.com
Study Locations
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-
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Ra'anana, Israel, 4330010
- Israeli Center for the Treatment of Dizziness and Imbalance
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
40 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Diagnosed with unilateral or bilateral vestibulopathy living independently in the community
Exclusion Criteria:
- cognitive state decline neurological disorder disease or disorders that can affect balance
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
No Intervention: control group
Patients in the control group will follow the doctor's instructions (medications and etc.) and will not participate in any physical therapy program.
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Experimental: PT treatment group for balance disorder
Patients in this research group will join to a 3 months' physical therapy treatment group designed to improve balance.
The service for the group is provided by laboratory.
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Exercises group transmitted by physical therapist (Up to four participant in each group).
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Experimental: independant home computerized exercises
Patients in this group will be treated by 3 months' independent home computerized exercise program.
Each patient will receive a personal access code for the exercise program.
The duration of each practice is 5-10 minutes per day.
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Remote exercises program accompanied by a physical therapist guidance
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change from baseline saccadic eye movements after 3 and 6 months measured by The video head impulse test (vhit)
Time Frame: up to 7 days after acute vestibulopathy, after 3 and 6 months after acute vestibulopathy
|
The Vhit incorporates a new technology that uses a high speed light weight video goggle to measure high velocity and record "catch up" saccades in patients with impaired VOR function.
we will examine the changes from baseline in the latency, frequency and duration of the overt and covert saccadic eye movements.
In addition, we would like to examine changes over time in the ratio between the head and the eye movement (Gain).
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up to 7 days after acute vestibulopathy, after 3 and 6 months after acute vestibulopathy
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change from baseline velocity sway at 3 and 6 months measured by force platform
Time Frame: up to 7 days after acute vestibulopathy, after 3 and 6 months after acute vestibulopathy
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The force plate is designed to measure the forces and moments applied to its top surface as a subjects stands, steps, or jumps on it.
Force plates are regularly used in research and clinical studies looking at balance, gait, and sports performance (www.amti.biz).
Center of pressure (COP) data during the stability tests will be sampled at a frequency of 100 Hz.
We will perform the zur balance scale (ZBS) on the plate at each time and evaluate the changes from baseline.
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up to 7 days after acute vestibulopathy, after 3 and 6 months after acute vestibulopathy
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Changes from baseline in balance confidence at 3 and 6 months after vestibulopathy measured by the ABC questionnire
Time Frame: up to 7 days after acute vestibulopathy, after 3 and 6 months after acute vestibulopathy
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The ABC is one of a several tools designed to measure an individual's confidence in her/his ability to perform daily activities without falling.
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up to 7 days after acute vestibulopathy, after 3 and 6 months after acute vestibulopathy
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Carmeli Eli, Prof, Haifa University
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Anticipated)
October 1, 2017
Primary Completion (Anticipated)
October 31, 2018
Study Completion (Anticipated)
December 31, 2019
Study Registration Dates
First Submitted
August 2, 2017
First Submitted That Met QC Criteria
August 31, 2017
First Posted (Actual)
September 5, 2017
Study Record Updates
Last Update Posted (Actual)
September 5, 2017
Last Update Submitted That Met QC Criteria
August 31, 2017
Last Verified
August 1, 2017
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- UHaifa2808
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Yes
IPD Plan Description
the data for all primary and secondary outcome measure will be available
IPD Sharing Time Frame
data will be available within 6 months of study completion
IPD Sharing Access Criteria
Requestor will be required to sign a data access agreement
IPD Sharing Supporting Information Type
- Study Protocol
- Informed Consent Form (ICF)
- Clinical Study Report (CSR)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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