- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03272841
TransplantLines: the Transplantation Biobank
September 2, 2017 updated by: Prof. dr. S.J.L. Bakker, MD, PhD, University Medical Center Groningen
TransplantLines is an observational cohort study in all solid transplant recipients, i.e. kidney, heart, lung, liver, small bowel and pancreas.
In this study we will gather questionnaires about topics affecting transplant recipients, e.g.
QoL, work and physical capacity.
Moreover, we will collect multiple urine and blood samples for analysis.
Additionally, we will store hair, nails and faeces from the transplant recipients.
Next to this, we will perform physical capacity tests and cognitive tests.
Study Overview
Status
Unknown
Conditions
Detailed Description
The last decades, the acute period after transplantation has markedly improved due to improved tissue-matching techniques and better immunosuppressive drugs.
However, nowadays the major aim after transplantation is the long-term patient and graft survival which are still poor, where half of the RTR looses their graft after 10 years.
With TransplantLines we are setting up an extensive biobank to improve the long-term survival after transplantation.
Moreover, we are one of the few studies to collect across transplant specialities.
Like mentioned in the brief summary, extensive questionnaires will be send to participants prior to the visit containing multiple questionnaires (e.g.
SF-36, WHODAS, PQ-SGA etc.).
During the visit, we will collect multiple blood samples who will be taken during the regularly visit to the clinician.
Moreover, two tubes from 24-hour urine collection will be collected, faeces, hair and nails will be stored.
Finally, physical tests and cognitive tests will be performed with the participants (e.g.
2-min walking test, 4m walking test, timed-up-and-go test etc.).
Study Type
Observational
Enrollment (Anticipated)
3000
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Groningen, Netherlands
- University Medical Center Groningen
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
All solid organ transplantation patients
Description
Inclusion Criteria:
- Solid organ transplant recipients
Exclusion Criteria:
- Age younger than 18 years old
- Cognitive dysfunction
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
---|
Transplant recipients
Renal, heart, lung, liver, small bowel, pancreas or combined transplant recipients
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Graft failure / mortality
Time Frame: Untill 2020
|
Development of graft failure or mortality in the transplant recipients
|
Untill 2020
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Vinke JSJ, Wouters HJCM, Stam SP, Douwes RM, Post A, Gomes-Neto AW, van der Klauw MM, Berger SP, Bakker SJL; TransplantLines Investigators; De Borst MH, Eisenga MF. Decreased haemoglobin levels are associated with lower muscle mass and strength in kidney transplant recipients. J Cachexia Sarcopenia Muscle. 2022 Aug;13(4):2044-2053. doi: 10.1002/jcsm.12999. Epub 2022 Jun 3.
- Sotomayor CG, Giubergia F, Groothof D, Ferreccio C, Nolte IM, Navis GJ, Gomes-Neto AW, Kremer D, Knobbe TJ, Eisenga MF, Rodrigo R, Touw DJ, Bakker SJL; TransplantLines Investigators. Plasma Lead Concentration and Risk of Late Kidney Allograft Failure: Findings From the TransplantLines Biobank and Cohort Studies. Am J Kidney Dis. 2022 Jul;80(1):87-97.e1. doi: 10.1053/j.ajkd.2021.10.009. Epub 2021 Dec 4.
- Shahabeddin Parizi A, Vermeulen KM, Gomes-Neto AW, van der Bij W, Blokzijl H, Buskens E, Bakker SJ, Krabbe PF. Using a novel concept to measure outcomes in solid organ recipients provided promising results. J Clin Epidemiol. 2021 Nov;139:96-106. doi: 10.1016/j.jclinepi.2021.07.005. Epub 2021 Jul 14.
- Douwes RM, Swarte JC, Post A, Annema C, Harmsen HJM, Bakker SJL. Discrepancy between self-perceived mycophenolic acid-associated diarrhea and stool water content after kidney transplantation. Clin Transplant. 2021 Jul;35(7):e14321. doi: 10.1111/ctr.14321. Epub 2021 May 2.
- Nolte S, van Londen M, Elting JWJ, de Greef BTA, Kuks JBM, Faber CG, Nolte IM, Groen RJM, Bakker SJL, Groothof D, Lesman-Leegte I, Berger SP, Drost G. Vibration threshold in non-diabetic subjects. PLoS One. 2020 Oct 7;15(10):e0237733. doi: 10.1371/journal.pone.0237733. eCollection 2020.
- Hijmans RS, van Londen M, Sarpong KA, Bakker SJL, Navis GJ, Storteboom TTR, de Jong WHA, Pol RA, van den Born J. Dermal tissue remodeling and non-osmotic sodium storage in kidney patients. J Transl Med. 2019 Mar 18;17(1):88. doi: 10.1186/s12967-019-1815-5.
- Hessels AC, van der Hoeven JH, Sanders JSF, Brouwer E, Rutgers A, Stegeman CA. Leg muscle strength is reduced and is associated with physical quality of life in Antineutrophil cytoplasmic antibody-associated vasculitis. PLoS One. 2019 Feb 4;14(2):e0211895. doi: 10.1371/journal.pone.0211895. eCollection 2019.
- Eisenga MF, Gomes-Neto AW, van Londen M, Ziengs AL, Douwes RM, Stam SP, Oste MCJ, Knobbe TJ, Hessels NR, Buunk AM, Annema C, Siebelink MJ, Racz E, Spikman JM, Bodewes FAJA, Pol RA, Berger SP, Drost G, Porte RJ, Leuvenink HGD, Damman K, Verschuuren EAM, de Meijer VE, Blokzijl H, Bakker SJL. Rationale and design of TransplantLines: a prospective cohort study and biobank of solid organ transplant recipients. BMJ Open. 2018 Dec 31;8(12):e024502. doi: 10.1136/bmjopen-2018-024502.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
June 1, 2015
Primary Completion (ANTICIPATED)
September 1, 2020
Study Completion (ANTICIPATED)
January 1, 2021
Study Registration Dates
First Submitted
September 2, 2017
First Submitted That Met QC Criteria
September 2, 2017
First Posted (ACTUAL)
September 6, 2017
Study Record Updates
Last Update Posted (ACTUAL)
September 6, 2017
Last Update Submitted That Met QC Criteria
September 2, 2017
Last Verified
September 1, 2017
More Information
Terms related to this study
Other Study ID Numbers
- TXLINES01
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Solid Organ Tranplant Recipients, 18+ Years
-
National Institute of Allergy and Infectious Diseases...Clinical Trials in Organ Transplantation in ChildrenCompletedSolid Organ Transplant Recipients | Parent(s)/Guardian of Referenced Transplant RecipientsUnited States
-
Michael IsonViraCor LaboratoriesCompletedInfection in Solid Organ Transplant Recipients | Awaiting Organ TransplantUnited States
-
Rabin Medical CenterCompletedInfection in Solid Organ Transplant RecipientsIsrael
-
University of California, Los AngelesActive, not recruitingInfection in Solid Organ Transplant RecipientsUnited States
-
Nuria LloberasMinisterio de Sanidad, Servicios Sociales e IgualdadCompletedInfection in Solid Organ Transplant RecipientsSpain
-
Hospices Civils de LyonWithdrawnSolid Organ Transplant RecipientsFrance
-
Methodist Health SystemCompletedInfection in Solid Organ Transplant RecipientsUnited States
-
Oxford ImmunotecCompletedInfection in Solid Organ Transplant RecipientsUnited States, United Kingdom, Canada
-
Duke UniversityBaylor College of Medicine; Children's Hospital of Philadelphia; Albert Einstein... and other collaboratorsCompletedRespiratory Viral Infection | Infection in Solid Organ Transplant Recipients | Complications of Organ TransplantUnited States
-
Imperial College LondonUniversity of Nottingham; Nottingham University Hospitals NHS Trust; NHS Blood... and other collaboratorsCompletedAutoimmune Diseases | Haematological Malignancies | Solid Organ Transplant RecipientsUnited Kingdom