Parkinson's Disease in African American and Caucasian Patients
Characteristics of African American People With Parkinson's Disease: A Hospital Based Study at the University of Chicago of the African American Community in Chicago's South Side
Lead Sponsor: University of Chicago
|Source||University of Chicago|
More than 10 million people worldwide are living with Parkinson's disease (PD). While the actual number of African Americans with PD is unknown, it is clear that there are racial disparities in the access to health care, and diagnosis and treatment of PD. The lack of clear knowledge on the lower PD prevalence among African Americans compared to Caucasians further calls for more research in this field. The University of Chicago Medicine is an ideal facility to study this topic, due to its location on the South Side of Chicago with large African American population. By analyzing the demographics, socioeconomics and clinical features of PD patients in our Center for Research Informatics in African Americans compared to the Caucasians of similar geographical area all accessible to the same health care facility, the Investigators aim to work toward a better understanding of the unique features of PD in American Americans, which might help improve the healthcare among the African Americans in Chicago and possibly nationwide. Blood will also be drawn during follow-up visits for future genetic studies, which might also help understand the genetic aspect of the disparity in PD.
The first portion of study will be database search of patients with Parkinson's disease - which will not require seeing the patients or conducting assessments in the clinic space. The second portion will involve clinical assessment and blood drawl at routine clinic visit.
The investigators will focus on African American PD patients who have access to health insurance and are from a similar geographic location as white PD patients. Among these two populations, demographics and socioeconomic status will be compared. Disease features, such as the duration after the onset to have the first visit, severity of the disease at the first visit, compliance in follow-up, co-morbidity rates, and milestones of the disease progression (aspiration pneumonia, wheelchair bound, nursing home, death, etc.) will also be assessed. Socioeconomic status will also be factored into the analysis. The investigators will also compare information from the United Parkinson's Disease Rating Scale (UPDRS), Parkinson's Disease Questionnaire (PDQ-39), Montreal Cognitive Assessment (MoCA) and Schwab and England Activities of Daily Living (SEADL).
The genetic differences between blacks and whites with PD are poorly understood and studied. As such, the investigators will also be collecting blood samples at patients' follow-up visits for future genetic analysis, such as mutations in the LRRK2 and GBA genes and even GWAS study, to see if there are significant differences in the genetic profiles of African American and Caucasian PD patients that account for the low PD prevalence rate in the black population
|Start Date||August 9, 2017|
|Completion Date||June 30, 2020|
|Primary Completion Date||June 30, 2020|
Intervention Type: Genetic
Intervention Name: Genetic testing
Description: Two tubes of blood samples for genetic testing.
Sampling Method: Non-Probability Sample
Inclusion Criteria: - 15 years and older, confirmed diagnosis of PD, African American or Caucasian race Exclusion Criteria: Non-PD -
- 15 years and older, confirmed diagnosis of PD, African American or Caucasian race
Exclusion Criteria: Non-PD
Minimum Age: 15 Years
Maximum Age: 100 Years
Healthy Volunteers: No
Last Name: Tao Xie, MD, PhD
Email: [email protected]
|Has Expanded Access||No|
Label: African American
Description: Patient of African American race
Description: Patient of Caucasian race
|Study Design Info||
Observational Model: Ecologic or Community
Time Perspective: Other