Parkinson's Disease in African American and Caucasian Patients

Characteristics of African American People With Parkinson's Disease: A Hospital Based Study at the University of Chicago of the African American Community in Chicago's South Side

Sponsors

Lead Sponsor: University of Chicago

Source University of Chicago
Brief Summary

More than 10 million people worldwide are living with Parkinson's disease (PD). While the actual number of African Americans with PD is unknown, it is clear that there are racial disparities in the access to health care, and diagnosis and treatment of PD. The lack of clear knowledge on the lower PD prevalence among African Americans compared to Caucasians further calls for more research in this field. The University of Chicago Medicine is an ideal facility to study this topic, due to its location on the South Side of Chicago with large African American population. By analyzing the demographics, socioeconomics and clinical features of PD patients in our Center for Research Informatics in African Americans compared to the Caucasians of similar geographical area all accessible to the same health care facility, the Investigators aim to work toward a better understanding of the unique features of PD in American Americans, which might help improve the healthcare among the African Americans in Chicago and possibly nationwide. Blood will also be drawn during follow-up visits for future genetic studies, which might also help understand the genetic aspect of the disparity in PD.

Detailed Description

The first portion of study will be database search of patients with Parkinson's disease - which will not require seeing the patients or conducting assessments in the clinic space. The second portion will involve clinical assessment and blood drawl at routine clinic visit.

The investigators will focus on African American PD patients who have access to health insurance and are from a similar geographic location as white PD patients. Among these two populations, demographics and socioeconomic status will be compared. Disease features, such as the duration after the onset to have the first visit, severity of the disease at the first visit, compliance in follow-up, co-morbidity rates, and milestones of the disease progression (aspiration pneumonia, wheelchair bound, nursing home, death, etc.) will also be assessed. Socioeconomic status will also be factored into the analysis. The investigators will also compare information from the United Parkinson's Disease Rating Scale (UPDRS), Parkinson's Disease Questionnaire (PDQ-39), Montreal Cognitive Assessment (MoCA) and Schwab and England Activities of Daily Living (SEADL).

The genetic differences between blacks and whites with PD are poorly understood and studied. As such, the investigators will also be collecting blood samples at patients' follow-up visits for future genetic analysis, such as mutations in the LRRK2 and GBA genes and even GWAS study, to see if there are significant differences in the genetic profiles of African American and Caucasian PD patients that account for the low PD prevalence rate in the black population

Overall Status Recruiting
Start Date August 9, 2017
Completion Date June 30, 2020
Primary Completion Date June 30, 2020
Study Type Observational
Primary Outcome
Measure Time Frame
Demographic information compared between African American and Caucasian population (year of diagnosis, symptom progression, healthcare details etc.) Through study completion - up to two years
Secondary Outcome
Measure Time Frame
The difference in genetic profiles in these two populations with PD Through study completion - up to two years
Enrollment 600
Condition
Intervention

Intervention Type: Genetic

Intervention Name: Genetic testing

Description: Two tubes of blood samples for genetic testing.

Eligibility

Sampling Method: Non-Probability Sample

Criteria:

Inclusion Criteria:

- 15 years and older, confirmed diagnosis of PD, African American or Caucasian race

Exclusion Criteria: Non-PD

-

Gender: All

Minimum Age: 15 Years

Maximum Age: 100 Years

Healthy Volunteers: No

Overall Official
Last Name Role Affiliation
Tao Xie, MD, PhD Principal Investigator University of Chicago
Overall Contact

Last Name: Tao Xie, MD, PhD

Phone: 7737023038

Email: [email protected]

Location
Facility: Status: Contact: Contact Backup: Investigator: University of Chicago Medical Center Tao Xie, MD, PhD 773-702-3081 [email protected] Tao Xie, MD, PhD Principal Investigator Mahesh Padmanaban, MD Sub-Investigator
Location Countries

United States

Verification Date

March 2020

Responsible Party

Type: Sponsor

Has Expanded Access No
Condition Browse
Arm Group

Label: African American

Description: Patient of African American race

Label: Caucasian

Description: Patient of Caucasian race

Patient Data No
Study Design Info

Observational Model: Ecologic or Community

Time Perspective: Other

Source: ClinicalTrials.gov