Community Acquired Sepsis Cohort (CASC)

The aim of this project is to constitute a prospective cohort of all the patients presenting to the adult emergencies of the University Hospital Centre (CHU) of Rennes for a septic syndrome of community origin.

Study Overview

• Status: Terminated
• Conditions: Septic Shock; Severe Septic Syndrome

Detailed Description

Severe septic syndrome (SSG) and septic shock (CS) are two frequent and serious complications of infectious diseases. In this context, the optimization of the management of septic patients from their reception in the emergency services must be a priority. However there are no predictors of progression or severity in patients admitted to emergencies despite the recommendations emphasizing the need for screening and early therapeutic management. Many scores have been proposed for intensive care unit but they remain difficult to extrapolate to other services because they are very comprehensive and require information that is difficult to obtain for emergency physicians.

• Study Type: Observational
• Enrollment (Actual): 796

Contacts and Locations

Study Locations

• France
  • Rennes, France, 35033
    • CHU de Rennes

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patient with a community infectious diseases

Description

Inclusion Criteria:

• Patient older than 18 years old
• Patient hospitalized during the study period for community infectious diseases at the CHU of Rennes

Exclusion Criteria:

• Written objection from the patient to the computer processing of his data
• Pregnant women
• Persons subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Assessment of morbidity in patients with septic syndrome of community origin	Study of prognostic factors	Day 90
Internal validity, severity score		Day 90
Internal validity, triage score by orientation nurses		Day 90
Study of the prognostic factors of patients with septic syndrome of community origin in terms of mortality		Day 90

Collaborators and Investigators

• Sponsor: Rennes University Hospital

Study record dates

Study Major Dates

• Study Start (ACTUAL): March 2, 2016
• Primary Completion (ACTUAL): August 27, 2018
• Study Completion (ACTUAL): August 27, 2018

Study Registration Dates

• First Submitted: August 18, 2017
• First Submitted That Met QC Criteria: September 12, 2017
• First Posted (ACTUAL): September 13, 2017

Study Record Updates

• Last Update Posted (ACTUAL): December 2, 2021
• Last Update Submitted That Met QC Criteria: December 1, 2021
• Last Verified: December 1, 2021

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Infections; Inflammation; Shock; Sepsis; Shock, Septic; Systemic Inflammatory Response Syndrome
• Other Study ID Numbers: 35RC16_3024_CASC

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No