Sensori-motor and Perceptual Functions of the PPC. (PPCfonctions)

Sensori-motor and Perceptual Functions of the Posterior Parietal Cortex (PPC) in Patients With Optic Ataxia (AO) and Healthy Subjects.

To produce hand's movement directed towards a target, the investigator must combine several sensory information, such as vision or proprioception. The posterior parietal cortex (PPC) is a region of the cortex involved in this multisensory integration. A lesion of the PPC cause a visuo-motor trouble called optic ataxia but these patients also have perceptual troubles.

The aim of the study is to understand the different functions of the PPC and especially how the processes of spatial coding of the sensory information influences perception and motor planning.

In this study, the investigator want to explore the sensory motor and the perceptual performance of patients with optic ataxia compared with healthy subjects, using 6 behavioral tests.

Objectify the consequences of PPC impairment (visual-motor and perceptual consequences) on patients' quality of life and autonomy.

Study Overview

• Status: Recruiting
• Conditions: Healthy Volunteers; Optic Ataxia
• Intervention / Treatment: Behavioral: point targets; Behavioral: tactile stimulation; Behavioral: visual images

• Study Type: Interventional
• Enrollment (Estimated): 160
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Laure Pisella, PhD; Phone Number: +33 4 72 91 34 05; Email: laure.pisella@inserm.fr

Study Locations

• France
  • Bron, France, 69500
    • Recruiting
    • U1028 INSERM - CNRS UMR 5292 Equipe ImpAct
    • Contact: Laure Pisella, PhD; Phone Number: +33 4 72 91 34 05; Email: laure.pisella@inserm.fr
    • Principal Investigator: Laure Pisella, PhD
    • Sub-Investigator: Sophie JACQUIN-COURTOIS, MD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 75 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

All patients and healthy subjects:

• male and female, age from 18 to 75 years included
• normal vision or corrected vision
• covered by social security
• signed written informed consent

Patients:

• neurological injury in posterior parietal cortex supported by a cerebral MRI
• present optic ataxia symptoms Healthy subjects
• no known neurological injury

Exclusion Criteria:

- unable to comply with the tasks (neurological, psychiatric, sensory or motor troubles)

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

6

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Experience 1	Behavioral: point targets; In the experiences 1 and 2, the participant needs to point different visual targets (LED) in the dark.
Experimental: Experience 2	Behavioral: point targets; In the experiences 1 and 2, the participant needs to point different visual targets (LED) in the dark.
Experimental: Experience 3	Behavioral: tactile stimulation; In the experience 3, a tactile stimulation is applied to the middle finger of the 2 hands. The participant needs to indicate into a microphone when he feels the stimulation.
Experimental: Experience 4	Behavioral: visual images; Target dots or visual images are presented on a computer screen. The participant is required to point to the targets or to react as soon as possible by pressing a response button when they are detected.
Experimental: Experience 5	Behavioral: visual images; Target dots or visual images are presented on a computer screen. The participant is required to point to the targets or to react as soon as possible by pressing a response button when they are detected.
Experimental: Experience 6	Behavioral: visual images; Target dots or visual images are presented on a computer screen. The participant is required to point to the targets or to react as soon as possible by pressing a response button when they are detected.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
response error - number of pointing error	Day 0 after each stimulation
response error -measure of reaction times	Day 0 after each stimulation
response error - percentage of right responses	Day 0 after each stimulation

Collaborators and Investigators

• Sponsor: Hospices Civils de Lyon
• Investigators: Principal Investigator: Laure PISELLA, PhD, INSERM U1028 - Impact - CRNL

Study record dates

Study Major Dates

• Study Start (Actual): February 22, 2018
• Primary Completion (Estimated): February 22, 2031
• Study Completion (Estimated): February 22, 2031

Study Registration Dates

• First Submitted: September 14, 2017
• First Submitted That Met QC Criteria: September 14, 2017
• First Posted (Actual): September 18, 2017

Study Record Updates

• Last Update Posted (Actual): January 20, 2026
• Last Update Submitted That Met QC Criteria: January 16, 2026
• Last Verified: January 1, 2026

More Information

Terms related to this study

• Keywords: multisensory integration; optic ataxia; posterior parietal cortex functions
• Additional Relevant MeSH Terms: Neurologic Manifestations; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Dyskinesias; Cerebellar Diseases; Ataxia; Cerebellar Ataxia
• Other Study ID Numbers: 69HCL17_0341; 2017-A02562-51 (Other Identifier: ID-RCB)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No