ACES - ACE Inhibitors Combined With Exercise for Seniors With Hypertension (ACES)

The purpose of this project is to conduct a randomized, controlled trial (RCT) to determine if choice of antihypertensive medication influences changes in functional status and other cardiovascular risk factors among older persons with hypertension when combined with physical exercise.

Study Overview

• Status: Active, not recruiting
• Conditions: Hypertension; Sedentary Lifestyle; Aging
• Intervention / Treatment: Behavioral: Aerobic exercise; Drug: Perindopril; Drug: Losartan; Drug: HCTZ

Detailed Description

The purpose of this project is to conduct a randomized, controlled trial (RCT) to determine if choice of antihypertensive medication influences changes in functional status and other cardiovascular risk factors among older persons with hypertension. Functional status, determined by measures of physical performance, is an important predictor of cardiovascular outcomes in older adults. Seniors with compromised function experience more CV events, have a higher risk of undergoing cardiac surgery and higher risk of CVD-related death than higher-functioning peers. Seniors with hypertension experience accelerated declines in function, and presently physical exercise is the primary strategy for preventing this decline. However, functional responses to exercise are highly variable and appear to be influenced by the type of antihypertensive medication(s) utilized to control blood pressure. Preliminary evidence suggests that, compared to other first-line antihypertensive agents, angiotensin converting enzyme (ACE) inhibitors enhance exercise-derived improvements in functional status among hypertensive seniors. This RCT will test this hypothesis. Sedentary men and women > 60 years of age with functional limitations and hypertension will be recruited from two sites to participate in a longitudinal intervention study. Participants will be randomly assigned to one of three first-line antihypertensive agents: (1) the ACE inhibitor perindopril, (2) AT1 receptor antagonist losartan, or (3) the thiazide diuretic hydrochlorothiazide. Note: Participants with a documented history of hypersensitivity to ACE inhibitors will be randomized 1:1 to one of the two other study drugs. All participants will also participate in a structured aerobic exercise intervention. The primary aim is to determine if, compared to losartan and HCTZ, perindopril improves self-paced gait speed. The secondary aim is to determine the relative effect of perindopril on a) exercise capacity, b) body mass and composition, and c) circulating indices of cardiovascular risk. This study is expected to differentiate beneficial effects of three FDA-approved antihypertensive medications on an emerging cardiovascular risk factor in a clinically-relevant population. Thus the study has important implications for expeditiously influencing clinical practice guidelines in the prescription of antihypertensive drugs to millions of Americans.

• Study Type: Interventional
• Enrollment (Estimated): 213
• Phase: Phase 2

Contacts and Locations

• Study Contact: Name: Thomas Buford, PhD; Phone Number: 2059963008; Email: twbuford@uabmc.edu

Study Locations

• United States
  • Alabama
    • Birmingham, Alabama, United States, 35205
      • UAB Center for Exercise Medicine
  • Florida
    • Orlando, Florida, United States, 32804
      • Translational Research Institute

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 60 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Age 60 years and older
• Hypertension - untreated (SBP ≥ 140 mm Hg or DBP ≥ 90 mm Hg) or treated
• > 290 seconds needed to complete long-distance corridor walk test
• Sedentary lifestyle, defined as <150 min/wk of moderate physical activity
• Willingness to participate in all study procedures, including allowing study team to communicate with primary care physician regarding changes in antihypertensive treatment

Exclusion Criteria:

• BP > 140/90, despite the use of three or more anti-hypertensive drugs
• SBP > 180 mm Hg or DBP > 110 mm Hg
• Chronic kidney disease
• Serum creatinine >2.5 mg/dL in men or >2.0 mg/dL in women
• Serum potassium outside normal reference range
• Urinary protein > 1 on dipstick
• Abnormal liver enzymes (AST, ALT, or alkaline phosphatase > 2.5 times the upper limit of normal)
• Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina
• Acute myocardial infarction identified by ECG
• Significant cognitive impairment, defined as a known diagnosis of dementia or a Mini-Mental State Examination exam score < 24;
• Simultaneous participation in another intervention trial
• Known hypersensitivity to ACE inhibitors (exclusion only to perindopril arm; will be randomized among other two interventions)
• Any other condition that would preclude participating based upon judgement of PI or study clinician team

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Quadruple

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Perindopril; 4 mg qd titrated to 8 mg qd perindopril + aerobic exercise	Behavioral: Aerobic exercise; Twice weekly centered based aerobic exercise + 3/week home-based walking; Drug: Perindopril; 4 mg qd titrated to 8 mg qd perindopril
Active Comparator: Losartan; 50 mg qd titrated to 100 mg qd losartan + aerobic exercise	Behavioral: Aerobic exercise; Twice weekly centered based aerobic exercise + 3/week home-based walking; Drug: Losartan; 50 mg qd titrated to 100 qd losartan
Active Comparator: HCTZ; 12.5 mg qd titrated to 25 mg qd HCTZ + aerobic exercise	Behavioral: Aerobic exercise; Twice weekly centered based aerobic exercise + 3/week home-based walking; Drug: HCTZ; 12.5 mg qd titrated to 25 qd HCTZ

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Gait speed	Self-paced gait speed over 4m distance	32 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Six minute walk test	maximal distance covered over six minutes	32 weeks
Body composition	% body fat/lean mass collected via dual x-ray absorptiometry	32 weeks
Circulating indices of cardiovascular risk	TNF-α, IL-6, VCAM-1, E-selectin; oxidized LDL; myeloperoxidase	32 weeks

Collaborators and Investigators

• Sponsor: University of Alabama at Birmingham
• Collaborators: University of Colorado, Denver; Translational Research Institute for Metabolism and Diabetes, Advent Health Hospital
• Investigators: Principal Investigator: Thomas Buford, PhD, University of Alabama at Birmingham; Principal Investigator: Bret Goodpaster, PhD, Translational Research Institute, Advent Health

Publications and helpful links

General Publications

• Harper SA, Baptista LC, Roberts LM, Wherry SJ, Boxer RS, Hildreth KL, Seay RS, Allman PH, Carter CS, Aban I, Kohrt WM, Buford TW. Angiotensin Converting Enzyme Inhibitors Combined with Exercise for Hypertensive Seniors (The ACES Trial): Study Protocol of a Randomized Controlled Trial. Front Med (Lausanne). 2020 Jan 22;6:327. doi: 10.3389/fmed.2019.00327. eCollection 2019.

Study record dates

Study Major Dates

• Study Start (Actual): May 29, 2018
• Primary Completion (Estimated): May 1, 2024
• Study Completion (Estimated): May 1, 2024

Study Registration Dates

• First Submitted: September 21, 2017
• First Submitted That Met QC Criteria: September 22, 2017
• First Posted (Actual): September 28, 2017

Study Record Updates

• Last Update Posted (Actual): March 22, 2024
• Last Update Submitted That Met QC Criteria: March 21, 2024
• Last Verified: March 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Hypertension; Molecular Mechanisms of Pharmacological Action; Anti-Arrhythmia Agents; Antihypertensive Agents; Enzyme Inhibitors; Protease Inhibitors; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Losartan; Perindopril

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: Yes
• Studies a U.S. FDA-regulated device product: No