Overall Diet Quality and Breast Cancer Risk

October 9, 2017 updated by: Vikram Haridass, University of California, Irvine

Diet Quality Scores and Risk of Incident Breast Cancer in Healthy Women

The purpose of this study was to examine the relationship between indices of overall diet quality and incident breast cancer risk in a large prospective cohort of women.

Study Overview

Status

Completed

Conditions

Detailed Description

This study examined the role of overall diet quality on the risk of developing invasive breast cancer among 96,959 women in the California Teachers Study, in which 4,826 women were diagnosed with breast cancer during follow-up (1995-2011). Participants' dietary habits were recorded at baseline (1995) using a 103-item Block95 Food Frequency Questionnaire to allow for the assessment of overall diet quality. Specifically, diet quality was characterized by the Alternate Mediterranean Diet (aMED), Alternative Healthy Eating Index-2010 (AHEI-2010), Dietary Approaches to Stop Hypertension (DASH), and Paleolithic Index scores. Associations between diet quality and the risk of developing breast cancer were examined using multivariate Cox proportional hazard regression models to provide hazard ratios and corresponding 95% confidence intervals.

Study Type

Observational

Enrollment (Actual)

96959

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Genders Eligible for Study

Female

Sampling Method

Non-Probability Sample

Study Population

Female participants of the California Teachers Study who met the eligibility criteria.

The California Teachers Study is comprised entirely of female participants aged 22-104 years old at enrollment who were current and former public school teachers and administrators and completed a 16-page mailed questionnaire at study entry in 1995-1996. Details of the California Teachers Study (CTS) have been described previously (Bernstein L, et al.; 2002).

Description

Inclusion Criteria:

  • Participants with no history of cancer diagnosis prior to baseline.
  • Participants with no history of myocardial infarction prior to baseline.
  • Participants with no history of stroke prior to baseline.
  • Participants with no history of diabetes prior to baseline.
  • Participants who are not missing excessive dietary data.
  • Participants with energy intake values at ≥1% and ≤99% of the population distribution.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Prospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Incident Invasive Breast Cancer
Time Frame: 1995-2011
All incident cancer cases were identified through linkage with the California Cancer Registry (CCR) records, which is a population-based cancer registry for California residents.
1995-2011

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of California, Irvine

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 1, 1995

Primary Completion (Actual)

December 31, 2011

Study Completion (Actual)

December 31, 2011

Study Registration Dates

First Submitted

October 3, 2017

First Submitted That Met QC Criteria

October 3, 2017

First Posted (Actual)

October 6, 2017

Study Record Updates

Last Update Posted (Actual)

October 11, 2017

Last Update Submitted That Met QC Criteria

October 9, 2017

Last Verified

October 1, 2017

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 1998-453

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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