Intravitreous CytokinE Level in pAtient With retiNal Detachment

Intravitreous CytokinE Level in pAtient With retiNal Detachment

Sponsors

Lead Sponsor: Central Hospital, Nancy, France

Source Central Hospital, Nancy, France
Brief Summary

Photoreceptor apoptosis is the basis for permanent visual loss in a number of retinal disorders including age-related macular degeneration (AMD) and retinal detachment (RD). Thus, despite tremendous advances in vitreoretinal surgery and management of rhegmatogenous RD leading to a primary reattachment rate over 95%, some patients show poor visual recovery because of photoreceptor apoptosis.

Physiologically, microglial cells (resident macrophages) are present only in the inner retina. The subretinal space, located between the retinal pigment epithelium (RPE) and the photoreceptor outer segments (POS), is devoid of all mononuclear phagocytes and form a zone of immune privilege. In AMD, several studies showed a strong association between subretinal mononuclear phagocytes infiltration and advanced forms of AMD. Experimental work in mice suggest that this infiltration plays an important role in the pathogenesis of this condition by producing inflammatory cytokines.

RD-induced photoreceptor apoptosis might result from similar mechanisms. The aim of this study is to determine the cytokine profile in vitreous samples from patients with RD and to compare it with those from control patients with macular hole.

Overall Status Unknown status
Start Date November 2017
Completion Date November 2019
Primary Completion Date May 2019
Study Type Observational
Primary Outcome
Measure Time Frame
Intravitreous cytokine levels up to one month after surgery
Enrollment 74
Condition
Intervention

Intervention Type: Procedure

Intervention Name: Vitrectomy

Description: Pars plana vitrectomy

Eligibility

Sampling Method: Probability Sample

Criteria:

Inclusion Criteria:

- Patients with primary retinal detachment requiring vitrectomy

- Patients with idiopathic macular hole requiring vitrectomy

Exclusion Criteria:

- History of retinal detachment or intraocular inflammatory diseases

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Overall Official
Last Name Role Affiliation
Jean-Baptiste CONART, MD Principal Investigator Brabois Hospital, Department of Ophthalmology
Overall Contact

Last Name: Jean-Baptiste CONART, MD

Phone: +(33)383155203

Email: [email protected]

Location
Facility: Brabois Hospital
Location Countries

France

Verification Date

October 2017

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Central Hospital, Nancy, France

Investigator Full Name: Docteur Jean-Baptiste CONART

Investigator Title: Medical Doctor

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Label: Case

Description: Patients undergoing vitrectomy for primary retinal detachment

Label: Control

Description: Patients undergoing vitrectomy for idiopathic macular hole

Acronym ICELAND
Patient Data Undecided
Study Design Info

Observational Model: Case-Control

Time Perspective: Prospective

Source: ClinicalTrials.gov