Neurorehabilitation Using a Virtual Reality-based Mirror Therapy

Effects of a Virtual Reality-Based Mirror NeuroRehabilitation System (VR-based MNRS) on Functional Performance of Upper Extremity for Unilateral Stroke Patients

Sponsors

Lead Sponsor: National Cheng-Kung University Hospital

Source National Cheng-Kung University Hospital
Brief Summary

In the proposed study, the investigators assumed that mirror therapy combined with virtual reality technology will provide a better treatment effects than traditional mirror therapy for the patients with unilateral stroke. The aim of the study is to examine the difference in the treatment effects among the combination of task-oriented training with either virtual reality based mirror therapy, mirror therapy or traditional occupational therapy on the upper extremity function and brain activity of the stroke patients.

Overall Status Recruiting
Start Date November 13, 2017
Completion Date October 2020
Primary Completion Date October 2020
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
Change in the result of Fugl-Meyer assessment (FMA) for motor function of upper extremity test baseline, 6 weeks and 18 weeks
Change in the result of Modified Ashworth scale (MAS) baseline, 6 weeks and 18 weeks
Change in the result of Box and blocks test baseline, 6 weeks and 18 weeks
Change in the result of Semmes-Weinstein monofilament (SWM) test baseline, 6 weeks and 18 weeks
Change in the result of Motor Activity Log baseline, 6 weeks and 18 weeks
Secondary Outcome
Measure Time Frame
Change in Power Spectrum of the Electroencephalography (EEG) baseline and 6 weeks
Changes in Cortical Excitability Assessed by Transcranial Magnetic Stimulation baseline and 6 weeks
Enrollment 66
Condition
Intervention

Intervention Type: Other

Intervention Name: task-oriented training

Description: Motor training targeted to goals that are relevant to the functional needs of the patient

Eligibility

Criteria:

Inclusion Criteria:

1. Clinical diagnosis of stroke with unilateral side involved;

2. A score of Mini-mental state examination greater than 24 for proving higher mental function;

3. Time of onset > 6 months before treatment begins, and

4. Premorbid right-handedness.

Exclusion Criteria:

1. Vision loss;

2. Major cognitive-perceptual deficit;

3. Other brain disease.

Gender: All

Minimum Age: 20 Years

Maximum Age: 80 Years

Healthy Volunteers: Accepts Healthy Volunteers

Location
Facility: Status: Contact: National Cheng-Kung University Hospital Hsiu-Yun Hsu, Ph.D. 886-6-2353535 2669 [email protected]
Location Countries

Taiwan

Verification Date

February 2020

Responsible Party

Type: Sponsor

Has Expanded Access No
Condition Browse
Number Of Arms 3
Arm Group

Label: Traditional occupational therapy

Type: Active Comparator

Description: The program includes 30 minutes of traditional occupational therapy (sensorimotor facilitation techniques, such as: Rood, Bobath and propriocetive-neuromuscular-facilitation), followed by 20 minutes of motor task specific training in each treatment session.

Label: Mirror therapy using a mirror box

Type: Active Comparator

Description: The program includes 30 minutes of mirror therapy, followed by 20 minutes of regular motor task specific training in each treatment session.

Label: Virtual reality based mirror therapy

Type: Experimental

Description: The program includes 30 minutes treatment session of virtual reality mirror therapy, followed by 20 minutes of motor task specific training in each treatment session.

Study Design Info

Allocation: Randomized

Intervention Model: Parallel Assignment

Primary Purpose: Treatment

Masking: Single (Outcomes Assessor)

Source: ClinicalTrials.gov