Dyslexia, Motor Control and Proprioception

Relationships Between Proprioception, Motor Control and Reading in Children With Dyslexia

The investigators hypothesize that children with dyslexia present proprioceptive disorders and the purpose of the present study is to better understand relationships between motor control, proprioception and academic learnings. The investigators compare a group of French students with and without dyslexia aged 10-12.

Study Overview

• Status: Terminated
• Conditions: Dyslexia
• Intervention / Treatment: Behavioral: Evaluation of proprioception; Behavioral: Evaluation of motor learning; Behavioral: Evaluation of written language

Detailed Description

2 groups of children (dyslexics and control) will be evaluated on 2 tasks:

• Evaluation of the proprioception: Perception of the speed and Perception of the position
• Evaluation of the motor learning: Estimation of state in the framework of a motor perturbation

• Study Type: Interventional
• Enrollment (Actual): 56
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Jeremie Gaveau, PH.D; Phone Number: +33380396772; Email: jeremie.gaveau@u-bourgogne.fr
• Study Contact Backup: Name: Julie LAPREVOTTE; Phone Number: 03 80 39 67 67; Email: Julie.Laprevotte@u-bourgogne.fr

Study Locations

• France
  • Bourgogne
    • Dijon, Bourgogne, France, 21000
      • Inserm U1093

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 10 years to 12 years (Child)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion criteria for all children

• Child with a French social security
• School child
• Native French speaker
• right-handed
• Normal or corrected vision
• Without neurological or psychiatric histories
• Agree to participate in the study in agreement with parental rights representatives

For the dyslexic group :

• pluridisciplinary diagnostic
• never consulted for proprioception before
• without any other leaning disorders like dysphasia
• attention deficit hyperactivity disorder (ADHD) or developmental coordination disorder (DCD)

For the control group :

• regular school attendance
• never consulted for learning disabilities
• No learning disorders known for their parents or siblings.

Exclusion criteria for all children

• genetic disorder
• neurological or psychiatric history
• Delayed psychomotor development
• Reeducation or current treatment interfering with the evaluation

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Dyslexic and non dyslexic Children; Children aged 10-12 Evaluation of proprioception Evaluation of motor learning Evaluation of written language	Behavioral: Evaluation of proprioception; Velocity perception and Position perception; Behavioral: Evaluation of motor learning; Motor accurancy and State Estimation with visual perturbations; Behavioral: Evaluation of written language; Text reading, Identifying words and Phonological awareness: phonemic blending and phonemic elision

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Evaluation of proprioception through velocity perception	The ability to perceive motion at 3 different velocities for 3 different joints is assessed using a motorized ergometer. A passive movement is performed by the ergometer and children are tasked to press a button as soon as they feel the movement. We calculate the angle of detection for each speed and compare it between Dyslexic and healthy children.	1day

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Evaluation of proprioception through position perception	The ability to perceive position is assessed using an ergometer that produces passive movements of 3 different amplitudes on the dominant arm. In a second time, the ergometer produces a passive movement of the same arm and children are tasked to press a button as soon as they feel they are in the exact previously-experienced position. We calculate the angular error and compare it between Dyslexic and healthy children.	1 day
Motor learning	The ability to learn new motor tasks is assessed using virtual reality and motor acquisition systems. First we evaluate the motor accuracy and the state estimation by pointing tests. Then visual perturbations are introduced during pointing. Finally, we evaluate motor accuracy and state estimation again.	1 day
Text reading	The ability to read aloud a text is assessed using the French standardized test " Alouette ", which provide accuracy in reading aloud age-normed texts (ratio between words that have been correctly read and all the words that have been read).	1day
Phonological awareness: phonemic blending and phonemic elision	The ability to derive a phonemic pattern from distinct phonemic units or to substitute a phonemic pattern for another is assessed using the French standardized test " Nepsy2, phonological process " which provide standard deviation in reading aloud by the investigator.	1day
Identifying words	The ability to identify words is assessed using the French standardized test " Timé3 ", which provide lexical level and delay reading in silent reading age-normed words.	1day

Collaborators and Investigators

• Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
• Investigators: Principal Investigator: Patrick QUERCIA, dr, Unité Inserm d'affiliation : Laboratoire U1093 Cognition, Action et Plasticité Sensorimotrice

Publications and helpful links

General Publications

• Laprevotte J, Papaxanthis C, Saltarelli S, Quercia P, Gaveau J. Movement detection thresholds reveal proprioceptive impairments in developmental dyslexia. Sci Rep. 2021 Jan 11;11(1):299. doi: 10.1038/s41598-020-79612-4.

Study record dates

Study Major Dates

• Study Start (Actual): January 4, 2018
• Primary Completion (Actual): May 9, 2019
• Study Completion (Actual): June 2, 2021

Study Registration Dates

• First Submitted: September 27, 2017
• First Submitted That Met QC Criteria: November 30, 2017
• First Posted (Actual): December 6, 2017

Study Record Updates

• Last Update Posted (Estimate): February 21, 2023
• Last Update Submitted That Met QC Criteria: February 17, 2023
• Last Verified: February 1, 2023

More Information

Terms related to this study

• Keywords: Motor control; Proprioception
• Additional Relevant MeSH Terms: Mental Disorders; Nervous System Diseases; Neurologic Manifestations; Neurobehavioral Manifestations; Neurodevelopmental Disorders; Language Disorders; Communication Disorders; Learning Disabilities; Dyslexia
• Other Study ID Numbers: C17-14; 2017-A01547-46 (Registry Identifier: RCB)

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No