- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03366103
Navitoclax and Vistusertib in Treating Patients With Relapsed Small Cell Lung Cancer and Other Solid Tumors
Phase 1/2 Study of Navitoclax Plus Vistusertib in Patients With Relapsed Small Cell Lung Cancer (SCLC) and Other Solid Tumors
Study Overview
Status
Conditions
- Refractory Malignant Solid Neoplasm
- Recurrent Malignant Solid Neoplasm
- Metastatic Malignant Solid Neoplasm
- Unresectable Solid Neoplasm
- Recurrent Lung Small Cell Carcinoma
- Stage IIIA Lung Small Cell Carcinoma AJCC v7
- Stage IIIB Lung Small Cell Carcinoma AJCC v7
- Stage IV Lung Small Cell Carcinoma AJCC v7
- Stage III Lung Small Cell Carcinoma, by American Joint Committee on Cancer (AJCC) v7
Intervention / Treatment
Detailed Description
PRIMARY OBJECTIVES:
I. To evaluate the safety and tolerability of the combination of navitoclax and vistusertib in patients with advanced solid tumors. (Phase I) II. To determine the maximum tolerated dose (MTD), dose limiting toxicities (DLT), and recommended phase 2 doses (RP2D) of navitoclax and vistusertib. (Phase I) III. To determine the objective response rate (ORR), defined as complete plus partial response, of the combination of navitoclax and vistusertib in patients with recurrent small cell lung cancer (SCLC). (Phase II)
SECONDARY OBJECTIVES:
I. To evaluate the pharmacokinetics of navitoclax and vistusertib when administered together. (Phase I) II. To observe and record anti-tumor activity. (Phase I) III. To confirm the safety and tolerability of navitoclax and vistusertib at the RP2D. (Phase II) IV. To estimate progression free survival (PFS) and overall survival (OS) of the combination of navitoclax and vistusertib at the RP2D. (Phase II) V. To estimate disease control rate (DCR) of the combination of navitoclax and vistusertib at the RP2D. (Phase II)
CORRELATIVE OBJECTIVES:
I. To assess pharmacodynamic changes in levels of phosphorylated 4EBP1 (p4EBP1) the ratio of p4EBP1 to total (p4EBP1/4EBP1) in paired pre-treatment and on-treatment biopsies at the RP2D. (Phase II) II. To correlate changes in BAX and MCL-1 with response. (Phase II) III. To estimate the baseline inter-patient variability in p4EBP1, pS6, BAX, and MCL-1. (Phase II) IV. To explore exposure-response relationships between navitoclax and vistusertib exposure and the pharmacodynamic endpoints (safety, efficacy, and laboratory correlatives). (Phase II)
OUTLINE: This is a phase I, dose-escalation study followed by a phase II study.
Patients receive navitoclax orally (PO) once daily (QD) and vistusertib PO twice daily (BID) on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up for 30 days and then every 8-12 weeks for up to 2 years.
Study Type
Enrollment (Actual)
Phase
- Phase 2
- Phase 1
Contacts and Locations
Study Locations
-
-
California
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Los Angeles, California, United States, 90033
- USC / Norris Comprehensive Cancer Center
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Los Angeles, California, United States, 90033
- Los Angeles County-USC Medical Center
-
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Maryland
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Baltimore, Maryland, United States, 21287
- Johns Hopkins University/Sidney Kimmel Cancer Center
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Massachusetts
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Boston, Massachusetts, United States, 02215
- Beth Israel Deaconess Medical Center
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Boston, Massachusetts, United States, 02215
- Dana-Farber Cancer Institute
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Boston, Massachusetts, United States, 02115
- Brigham and Women's Hospital
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Boston, Massachusetts, United States, 02114
- Massachusetts General Hospital Cancer Center
-
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New Jersey
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Basking Ridge, New Jersey, United States, 07920
- Memorial Sloan Kettering Basking Ridge
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Middletown, New Jersey, United States, 07748
- Memorial Sloan Kettering Monmouth
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Montvale, New Jersey, United States, 07645
- Memorial Sloan Kettering Bergen
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New York
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Commack, New York, United States, 11725
- Memorial Sloan Kettering Commack
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Harrison, New York, United States, 10604
- Memorial Sloan Kettering Westchester
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New York, New York, United States, 10065
- Memorial Sloan Kettering Cancer Center
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Uniondale, New York, United States, 11553
- Memorial Sloan Kettering Nassau
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- PHASE 1 SPECIFIC ELIGIBILITY CRITERIA
- Patients must have histologically or cytologically confirmed malignancy that is metastatic or unresectable and for which standard curative or palliative measures do not exist or are no longer effective
- PHASE 2 SPECIFIC ELIGIBILITY CRITERIA
- Patients must have histologically or cytologically confirmed small cell lung cancer whose disease has relapsed or progressed after >= 1 prior therapy, one of which must have been a platinum doublet; pathology confirmation must be done at Sidney Kimmel Comprehensive Cancer Center (SKCCC) or at the local participating site
- Patients must have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded for non-nodal lesions and short axis for nodal lesions) as >= 20 mm (>= 2 cm) by chest x-ray or as >= 10 mm (>= 1 cm) with computed tomography (CT) scan, magnetic resonance imaging (MRI), or calipers by clinical exam
- Subjects must be willing to undergo 2 sets of core needle biopsies (pre-treatment and on-treatment), if there are lesions amenable to biopsy; an optional core biopsy will be requested at progression
- GENERAL ELIGIBILITY CRITERIA
- Eastern Cooperative Oncology Group (ECOG) performance status =< 1 (Karnofsky >= 70%)
- Life expectancy of greater than 12 weeks
- Leukocytes >= 3,000/mcL
- Absolute neutrophil count >= 1,500/mcL
- Hemoglobin >= 9.0 g/dL
- Platelets >= 100,000/mcL
- Activated partial thromboplastin time (aPTT), prothrombin time (PT) =< 1.2 x upper limit of normal (ULN)
- Total bilirubin =< 1.5 x ULN (patients with Gilbert's syndrome may have serum bilirubin > 1.5 ULN)
- Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional ULN if no demonstrable liver metastases or =< 5 x ULN in the presence of liver metastases
- Creatinine =< 1.5 x ULN and concurrent creatinine clearance (CrCl) >= 50 mL/min/1.73 m^2 for patients with creatinine (Cr) > 1.5 x ULN
- Proteinuria < 1+ on dipstick testing (if 2+ seen on first test, retest >= 24 hours later)
- Patients with a history of central nervous system (CNS) metastases must have documentation of stable or improved status based on brain imaging for at least 2 weeks after completion of definitive treatment and within 2 weeks prior to first dose of study drug, off or on a stable dose of corticosteroids
- Patients must have completed chemotherapy, biological or radiotherapy >= 3 weeks prior to entering the study
- Patients must have recovered to =< grade 1 adverse events or to =< grade 2 alopecia and sensory neuropathy due to prior treatment
- Patients must be able to understand and the willingness to sign a written informed consent document
- Patients must be able to swallow pills
The effects of navitoclax and vistusertib on the developing human fetus are unknown; for this reason, women of child-bearing potential and men must agree to use adequate contraception prior to study entry, for the duration of study participation, and up to 90 days following completion of therapy; for women this should include one highly effective method of contraception and one barrier method as defined below
Highly effective methods include:
- Total abstinence from sexual intercourse (minimum one complete menstrual cycle prior to study drug administration);
- Vasectomized partner;
- Medroxyprogesterone acetate depot injection;
- Placement of a copper-banded intrauterine device (IUD) or intrauterine system (IUS);
- Bilateral tubal ligation;
Barrier methods include:
- Condom;
- Occlusive cap (e.g. diaphragm or cervical/vault caps) with spermicide
- Please note: use of other oral, injected or implanted hormonal methods of contraception cannot be considered highly effective as it is currently unknown whether vistusertib may reduce their effectiveness; periodic abstinence, the rhythm method, and the withdrawal method are not acceptable methods of contraception
- Additionally, male subjects (including those who are vasectomized) whose partners are pregnant or might be pregnant must agree to use condoms for the duration of the study and for 90 days following completion of therapy
- Women of childbearing potential must have a negative urine pregnancy test within 7 days prior to initiation of treatment, women will be considered not of childbearing potential if they are surgically sterile (bilateral oophorectomy or hysterectomy) and/or post-menopausal (amenorrheic for at least 12 months)
- Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately; men treated or enrolled on this protocol must also agree to use adequate contraception prior to the study, for the duration of study participation, and for 90 days after completion of navitoclax and/or vistusertib administration
Exclusion Criteria:
- PHASE 2 SPECIFIC EXCLUSION CRITERIA
- Prior treatment with a TORC1, dual TORC1/2 inhibitor, or BCL-2/xL inhibitor
- Patients with active malignancies other than SCLC or patients with prior curatively treated malignancy at high risk of relapse during the study period with the exception of localized squamous or basal cell skin cancers
- PHASE 1 AND GENERAL EXCLUSION CRITERIA
- Major surgery within 21 days of starting protocol treatment
- Patients who are receiving any other investigational agents
- History of allergic reactions attributed to compounds of similar chemical or biologic composition to navitoclax or vistusertib
Patients receiving anticoagulation or anti-platelet therapy are excluded due to the risk of thrombocytopenia with navitoclax
- Excluded agents include heparin or low molecular weight heparin, warfarin, clopidogrel, ibuprofen and other non-steroidal anti-inflammatory drugs (NSAIDS), tirofiban, and other anticoagulants, drugs, or herbal supplements that affect platelet function
- Administration of heparin to keep subject's infusion lines patent is allowed; low-dose anticoagulation medications that are used to maintain the patency of a central intravenous catheter are allowed
- Aspirin will not be allowed within 7 days prior to the first dose of navitoclax or during navitoclax administration; however, subjects who have previously received aspirin therapy for thrombosis prevention, may resume a low dose (i.e., maximum 100 mg once daily [QD]) of aspirin if platelet counts are stable (>= 50,000/mm3) through 6 weeks of navitoclax administration
- All decisions regarding treatment with aspirin therapy will be determined by the investigator in conjunction with the medical monitor
- Patients with an underlying condition predisposing them to bleeding or currently exhibiting signs of clinically significant bleeding
- Patients with a recent history of non-chemotherapy-induced thrombocytopenic-associated bleeding within 1 year prior to the first dose of study drug
- Patients with a significant history of cardiovascular disease or procedures within the preceding 6 months (e.g., myocardial infarction [MI], coronary artery bypass graft placement, angioplasty, vascular stent, angina pectoris, ventricular arrhythmias requiring continuous therapy, congestive heart failure New York Heart Association [NYHA] grade >= 2, thrombotic or thromboembolic event)
Any of the following cardiac criteria:
- Mean resting corrected QT interval (QTc using Fridericia's formula [QTcF]) > 470 msec obtained from 3 electrocardiograms
- Congenital or family history of long or short QT syndrome, Brugada syndrome, known history of QTc prolongation or torsades de pointes within 12 months of entering the study
- Abnormal echocardiogram at baseline (left ventricular ejection fraction [LVEF] < 40% and shortening fraction [SF] < 15%)
- Drugs which have an increased risk for QTc prolongation should be avoided
- Patients with uncontrolled type 1 or type 2 diabetes. Vistusertib belongs to a class of drugs that causes hyperglycemia. In order to assess toxicity, patients with an elevated risk of hyperglycemia should be excluded from study
Patients currently receiving medications or herbal supplements of the classes below are ineligible; patients are eligible if they stop use of these compounds at least 1 week prior to receiving any treatment on this protocol
- Potent inhibitors or inducers of CYP3A4 /5 (CYP3A4 inhibitors such as ketoconazole and clarithromycin are not allowed 7 days prior to the first dose of navitoclax and during navitoclax administration)
- Strong or moderate inhibitors of Pgp or BRCP1
- Sensitive substrates of CYP2C9 (i.e. phenytoin and warfarin)
- Substrates of certain drug transporters (OATP1B1, OATP1B3, MATE1 or MATE2K)
- Pregnant women are excluded from this study because navitoclax and vistusertib have the potential for teratogenic or abortifacient effects; because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with navitoclax and vistusertib breastfeeding should be discontinued if the mother is treated with navitoclax and vistusertib
Patients positive for human immunodeficiency virus (HIV) are not excluded from this study, but HIV-positive patients must have:
- A stable regimen of highly active anti-retroviral therapy (HAART) that does not include strong or moderate CYP3A4 inducers or inhibitors
- No requirement for concurrent antibiotics or antifungal agents for the prevention of opportunistic infections
- A CD4 count above 250 cells/mcL and an undetectable HIV viral load on standard polymerase chain reaction (PCR)-based test
- Any hematopoietic growth factors (e.g., filgrastim [granulocyte colony-stimulating factor; G-CSF], sargramostim [granulocyte-macrophage colony-stimulating factor; GM-CSF]) within 14 days prior to receiving study treatment
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- Patients who have received a live, attenuated vaccines within 4 weeks of first dose of drug
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Treatment (navitoclax, vistusertib)
Patients receive navitoclax PO QD and vistusertib PO BID on days 1-28.
Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.
|
Given PO
Other Names:
Given PO
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Number of Participants With Dose Limiting Toxicities (Phase I)
Time Frame: Up to 30 days after last treatment, an average of 3 months
|
Graded by National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version (v) 4.0.
The number of participants with dose limiting toxicities at each dose level will be reported with exact binomial 95% confidence intervals.
All patients who receive at least 1 dose of both study drugs, regardless of their eligibility for the study, will be evaluable for toxicity.
|
Up to 30 days after last treatment, an average of 3 months
|
Overall Response Rate (ORR) (Phase II)
Time Frame: Up to 1.5 years
|
Defined as Response Evaluation Criteria in Solid Tumors (RECIST) 1.1.
partial response or complete response, of the combination in patients with recurrent small cell lung cancer.
The ORR will be reported with its corresponding 95% confidence interval.
|
Up to 1.5 years
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Occurrence of a Bi-directional Pharmacokinetic (PK) Interaction
Time Frame: Through Day 15
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Concentrations of each study agent present in the blood at the specified time point are reported for each study agent.
|
Through Day 15
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Number of Participants Experiencing Adverse Events by Grade (Phase II)
Time Frame: Up to 1.5 years
|
Graded by NCI CTCAE v 4.0.
The number of participants with toxicities by grade in the phase 2 study will be reported with exact binomial 95% confidence intervals.
|
Up to 1.5 years
|
Progression Free Survival (PFS) (Phase II)
Time Frame: Up to 1.5 years
|
Based on RECIST 1.1.
Standard life table methods will be used to analyze PFS.
We will report the one-year and median PFS with 95% confidence intervals.
|
Up to 1.5 years
|
Overall Survival (OS) at Year 1 (Phase II)
Time Frame: At Year 1
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Standard life table methods will be used to analyze OS.
We will report the one-year and median OS with 95% confidence intervals.
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At Year 1
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Disease Control Rate (Phase II)
Time Frame: Up to 1.5 years
|
Based on RECIST 1.1.
The proportion of patients achieving disease control will be reported with exact 95% binomial confidence intervals.
|
Up to 1.5 years
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in p4EBP1 Expression
Time Frame: Baseline up to 1.5 years
|
Descriptive statistics and box plots with jittered data points will be used to visualize all raw data.
Will be assessed with paired t-tests.
|
Baseline up to 1.5 years
|
Change in Ratio p4EBP1/4EBP1
Time Frame: Baseline up to 1.5 years
|
Descriptive statistics and box plots with jittered data points will be used to visualize all raw data.
Will be assessed with paired t-tests.
|
Baseline up to 1.5 years
|
Change in Ratio pS6/S6
Time Frame: Baseline up to 1.5 years
|
Descriptive statistics and box plots with jittered data points will be used to visualize all raw data.
Will be assessed with paired t-tests.
|
Baseline up to 1.5 years
|
Change in BAX and MCl-1 Expression
Time Frame: Baseline up to 1.5 years
|
Descriptive statistics and box plots with jittered data points will be used to visualize all raw data.
Will be assessed with paired t-tests.
|
Baseline up to 1.5 years
|
Pharmacodynamic Parameters
Time Frame: Up to 1.5 years
|
Exploratory correlative studies with pharmacodynamic (biological endpoints, toxicity and efficacy) will be analyzed using nonparametric statistics.
|
Up to 1.5 years
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Christine L Hann, JHU Sidney Kimmel Comprehensive Cancer Center LAO
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pathologic Processes
- Respiratory Tract Diseases
- Neoplasms by Histologic Type
- Lung Diseases
- Neoplasms by Site
- Neoplasms, Glandular and Epithelial
- Disease Attributes
- Respiratory Tract Neoplasms
- Thoracic Neoplasms
- Carcinoma, Bronchogenic
- Bronchial Neoplasms
- Lung Neoplasms
- Neoplasms
- Carcinoma
- Recurrence
- Small Cell Lung Carcinoma
- Carcinoma, Small Cell
- Antineoplastic Agents
- Navitoclax
Other Study ID Numbers
- NCI-2017-00037 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- UM1CA186691 (U.S. NIH Grant/Contract)
- 10070 (Other Identifier: CTEP)
- ETCTN10070
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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