Effects of Sleep Privation on Sensorimotor Integration of the Upper Limb During a Manual Endurance Test in Healthy Volunteers-Physiological Study

The investigator showed that a night of sleep deprivation halved the duration of an inspiratory endurance test and that this loss of endurance could be secondary to a lack of activation of the pre-motor cortex. However, the inspiratory endurance test is associated with a feeling of dyspnea that could lead to premature arrest, and the inspiratory drive is complex, both automatic and voluntary. The investigator can reproduce this results on a simpler drive.

During the execution of an exercise involving repeated contractions of the hand it is possible to record the activation of the pre-motor cortex corresponding to the phase of preparation of the movement. The amplitude of these premotor potentials is proportional to the developed motive force.

The purpose of this study is to assess the impact of sleep deprivation on the muscular endurance of non-dominant in healthy subjects.

Hypothesis: Sleep deprivation causes a decrease in manual motor endurance by decreasing cortical pre-motor control.

Main objective: To compare the motor endurance of healthy subjects after a night's sleep and after a sleepless night.

Secondary objective: To compare the amplitude of premature cortical control at the beginning of the endurance test after a night's sleep and after a sleepless night.

Study Overview

• Status: Completed
• Conditions: Healthy Volunteers; Sleep Deprivation; Skeletal Muscle
• Intervention / Treatment: Behavioral: Normal sleep night; Behavioral: Sleepless night

• Study Type: Interventional
• Enrollment (Actual): 21
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Vienne
    • Poitiers, Vienne, France, 86021
      • Centre Hospitalier de Poitiers

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 25 years to 45 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• adult male volunteers;
• 25 to 45 years old
• regularly sleeping more than 6 hours per night;
• no excessive consumers of coffee (<3 espressos / day);
• absence of muscular or neurological pathology ;
• with a BMI> 18 and <25 kg / m²;
• Horne and Ostberg score> 31 and <69 ;

Exclusion Criteria:

• female sex
• history of neuromuscular disease ;
• implanted metallic or electronic equipment (vascular stent, ocular implant, pacemaker ...)
• history of epilepsy, or discomfort after sleep deprivation ;
• poor sleepers (PSQI> 5);
• exercising an activity in staggered hours;
• regularly performing more than 2 nights without sleep per month;
• taking drugs interfering with sleep (antidepressants, benzodiazepines ...);
• having crossed 4 time zones in the previous 4 weeks.
• current participation in another clinical research study;

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Sham Comparator: Normal sleep night; The first endurance test is the endurance motor control test after a normal sleep night.	Behavioral: Normal sleep night; Usual hours of sleep
Experimental: Sleepless night; The first endurance test is the endurance motor test after a sleepless night.	Behavioral: Sleepless night; Total sleep deprivation the first night

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Test duration	Time, in minutes, measured between the beginning of the endurance test and the end of the test, defined by the volunteer's inability to maintain a force of at least 30% of the maximum strength for 5 seconds.	1 hour.

Collaborators and Investigators

• Sponsor: Poitiers University Hospital
• Investigators: Principal Investigator: Xavier Drouot, Poitiers university hospital

Study record dates

Study Major Dates

• Study Start (Actual): February 14, 2019
• Primary Completion (Actual): March 4, 2020
• Study Completion (Actual): March 4, 2020

Study Registration Dates

• First Submitted: January 12, 2018
• First Submitted That Met QC Criteria: January 12, 2018
• First Posted (Actual): January 19, 2018

Study Record Updates

• Last Update Posted (Actual): April 21, 2020
• Last Update Submitted That Met QC Criteria: April 20, 2020
• Last Verified: April 1, 2020

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Nervous System Diseases; Dyssomnias; Sleep Wake Disorders; Neurologic Manifestations; Sleep Deprivation
• Other Study ID Numbers: HANDY-SLEEP

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No