The European Prospective Investigation Into Cancer in Norfolk Prospective Population Study (EPIC-Norfolk)

The European Prospective Investigation into Cancer and Nutrition in Norfolk is a population based prospective study of approximately 25,000 men and women resident in Norfolk United Kingdom. They were aged 39-79 years when first recruited from general practice age sex registers at baseline assessment 1993-1997. While part of a ten country half million participant European collaboration originally aimed to investigate diet and other lifestyle determinants of cancer, the objectives of the Norfolk cohort from inception were expanded to encompass the trajectory of health, ill health and mortality in a population over time and to examine the biological and lifestyle determinants of health and chronic disease.

Study Overview

• Status: Active, not recruiting
• Conditions: Cardiovascular Diseases; Neoplasms; Death
• Intervention / Treatment: Behavioral: diet

Detailed Description

The European Prospective Investigation into Cancer and Nutrition in Norfolk is a population based prospective study of approximately 25,000 men and women resident in Norfolk United Kingdom. They were aged 39-79 years when first recruited from general practice age sex registers at baseline assessment 1993-1997. While part of a ten country half million participant European collaboration originally aimed to investigate diet and other lifestyle determinants of cancer, the objectives of the Norfolk cohort from inception were expanded to encompass the trajectory of health, ill health and mortality in a population over time and to examine the biological and lifestyle determinants of health and chronic disease. Detailed data on sociodemographic, lifestyle, medical and family history were collected and a biological sample bank including urine and blood samples established. Participants have been followed up through repeat examinations, mailed questionnaires as well as through record linkage with routine health records including death certification by cause, cancer registration and hospital admissions by cause till present.

• Study Type: Observational
• Enrollment (Actual): 25639

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 39 years to 79 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Resident in Norfolk, United Kingdom on general practice age sex registers 1993-1997

Description

Inclusion Criteria:

• Willing to participate
• On general practice age sex registers in Norfolk, United Kingdom in 1993-1997

Exclusion Criteria:

• Not willing to participate in study
• terminal illness

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
neoplasms	cancer incidence	Through 25 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
cardiovascular diseases	incidence of cardiovascular diseases	through 25 years
death	total mortality by cause	through 25 years

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
fractures	incident fractures	through 25 years
diabetes mellitus	incident diabetes	through 25 years

Collaborators and Investigators

• Sponsor: University of Cambridge
• Collaborators: Medical Research Council; Cancer Research UK
• Investigators: Principal Investigator: Kay-Tee Khaw, MBBChir, University of Cambridge; Principal Investigator: Nicholas Wareham, MBBS, University of Cambridge

Publications and helpful links

General Publications

• Day N, Oakes S, Luben R, Khaw KT, Bingham S, Welch A, Wareham N. EPIC-Norfolk: study design and characteristics of the cohort. European Prospective Investigation of Cancer. Br J Cancer. 1999 Jul;80 Suppl 1:95-103. No abstract available.
• Bingham SA, Welch AA, McTaggart A, Mulligan AA, Runswick SA, Luben R, Oakes S, Khaw KT, Wareham N, Day NE. Nutritional methods in the European Prospective Investigation of Cancer in Norfolk. Public Health Nutr. 2001 Jun;4(3):847-58. doi: 10.1079/phn2000102.

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 1992
• Primary Completion (Anticipated): December 31, 2040
• Study Completion (Anticipated): December 31, 2040

Study Registration Dates

• First Submitted: January 25, 2018
• First Submitted That Met QC Criteria: January 31, 2018
• First Posted (Actual): February 7, 2018

Study Record Updates

• Last Update Posted (Actual): April 16, 2019
• Last Update Submitted That Met QC Criteria: April 15, 2019
• Last Verified: April 1, 2019

More Information

Terms related to this study

• Keywords: physical activity; nutrition; smoking; lifestyle
• Additional Relevant MeSH Terms: Cardiovascular Diseases
• Other Study ID Numbers: MR/N003284/1

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: EPIC Norfolk follows Medical Research Council UK good practice for data sharing. Requests for data are submitted to the EPIC Norfolk management committee to assess scientific feasibility and avoid duplication and within the requirements of NHS Digital data protection rules.
• IPD Sharing Time Frame: Data are available after collection, cleaning and quality control
• IPD Sharing Access Criteria: Bonafide researchers
• IPD Sharing Supporting Information Type: STUDY_PROTOCOL; SAP; ICF

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No