Anesthetic Cost Analysis With Desflurane in Automated Gas Control Mode

Anesthetic Cost Analysis With Desflurane in Automated Gas Control Mode With Maquet Flow-i Anaesthesia Machine

Inhalation agents constitute the major part of anesthetic drug costs (20% - 25%) and a significant portion of the applied inhalation agents are thrown into the atmosphere through the waste gas system without being absorbed by the patient. The amount of waste gas is directly correlated to the fresh gas flow (FGF). Reducing the TGA during general anesthesia reduces the consumption of inhalant agents and contributes to the reduction of greenhouse gas pollution. Risks such as hypoxia, hypercapnia, inadequate depth of anesthesia and potential toxic gas accumulation were associated with low flow anesthesia, but the patient was provided with adequate safety by following pulse oximetry, capnography, FiO2 and anesthetic gas analysis. We aimed to perform anesthetic cost analysis and patient security in automated gas control mode (AGC).

Study Overview

• Status: Completed
• Conditions: Safety Issues

Detailed Description

After the ethical approvel 60 adult patients scheduled for hepatectomy will be taken to study. Patients will be monitored after they are taken to the operating room (ECG, NIBP, SpO2, Body Temp, BIS, NIRS, PVI, PI, ORI). After the anesthesia induction and tarakeal entubation, first twenty patient will take 300 mL fresh gas flow with AGC mode (group 1), Second twenty patient will take 600 mL fresh gas flow with AGC mode (group 2), third twenty patient will take 600 mL fresh gas flow with manually. Hemodynamic and gas consumption data will be recorded. An operating room will be reserved for this study.

• Study Type: Observational
• Enrollment (Actual): 60

Contacts and Locations

Study Locations

• Turkey
  • Malatya, Turkey, 44280
    • Inonu Univercity

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 65 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients undergoing hepatectomy operation

Description

Inclusion Criteria:

• Adult patients undergoing hepatectomy with general anesthesia

Exclusion Criteria:

• Essential data missing
• Patient participating in other research projects
• Drug allergy
• Anesthetic complication story

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort
Group 1; The patient who receive 300 mL fresh gas flow with AGC mode during the general anesthesia
Group 2; The patient who receive 600 mL fresh gas flow with AGC mode during the general anesthesia
Group 3; The patient who receive 600 mL fresh gas flow with manuelly during the general anesthesia

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Amount of used anesthetic gas (desflurane)	Amount of used desflurane will be determined in milliliter by anesthesia machine (Maquet Flow i40) for each patient.	Through study completion, an average of 2 month

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Heart rate	Heart rate/min	Through study completion, an average of 2 month
Mean arterial pressure	Mean arterial pressure (mm/Hg)	Through study completion, an average of 2 month
Peripheral oxygen saturation	Peripheral oxygen saturation (%)	Through study completion, an average of 2 month

Collaborators and Investigators

• Sponsor: Inonu University
• Investigators: Principal Investigator: Yusuf Z Çolak, MD, Investigator

Study record dates

Study Major Dates

• Study Start (Actual): July 1, 2018
• Primary Completion (Actual): October 30, 2020
• Study Completion (Actual): March 1, 2021

Study Registration Dates

• First Submitted: February 1, 2018
• First Submitted That Met QC Criteria: March 13, 2018
• First Posted (Actual): March 14, 2018

Study Record Updates

• Last Update Posted (Actual): August 25, 2021
• Last Update Submitted That Met QC Criteria: August 24, 2021
• Last Verified: August 1, 2021

More Information

Terms related to this study

• Keywords: Desflurane; Cost analysis; Low flow anesthesia; Automated gas control
• Other Study ID Numbers: Inonu uni

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No