Essential Tremor in Children and Adolescent

Clinical and Electrophysiological Characterization of Essential Tremor in Children and Adolescents

Essential tremor (TE) is the most common abnormal movement of the adult. His diagnosis is based on a bundle of clinical arguments (Movement Disorders Society, 1998). Well characterized in the adult, little data is available concerning child. The objective of this work is (1) to define the demographic and clinical characteristics of the TE of children and adolescents, (2) to determine the electrophysiological characteristics in the child, (3) evaluate the functional impact of TE, and assess the functional impact of TE, and assess the current management modalities of TE in children and adolescent.

Study Overview

• Status: Terminated
• Conditions: Essential Tremor
• Intervention / Treatment: Other: electromyographic essential tremor

Detailed Description

A multicenter, descriptive cross-sectional study will include children and adolescents whose diagnosis of TE has been retained by an abnormal movement specialist before the age of 18 years.

Each child will benefit from an examination and a neurological and general clinical examination, a functional questionnaire, an electromyogram with accelerometer.

Will be determined: demographic characteristics (age, sex and ethnicity), family history of essential tremor, age of onset of tremor, tremor characteristics (location, occurrence conditions, aggravating or precipitating factors, scalability); additional examinations carried out and the treatments proposed or taken by the child as well as the functional repercussions of TE in the child.

Patients with tremor who meet the inclusion and exclusion criteria will be selected retrospectively or prospectively from the active queue of patients at each center.

• Study Type: Interventional
• Enrollment (Actual): 18
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Montpellier, France, 34295
    • CHU Gui de Chauliac

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 3 years to 18 years (Child, Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Subject whose age is between 3 and 18 years
• Subject affiliated to a social security scheme
• Parents or subjects who have been informed of the course and consequences of the study by an investigator and who have signed the informed consent form for prospective inclusion or who have given their non-opposition for retrospective inclusion.
• Diagnosis of essential tremor established according to the diagnostic criteria of the Movement Disorders Society (1998), by a neuropediatrician or a neurologist, specialist in abnormal movements. The diagnosis is based on the presence of the following criteria: bilateral action tremor of the hands and forearms, absence of other neurological signs.
• Availability of an electromyogram for retrospective inclusions.

Exclusion Criteria:

• Abnormal neurological examination outside tremor
• Family history or personal dysthyroidism
• Existence of a global psychomotor or motor developmental delay
• Taking medication that may induce tremor
• known poisoning by heavy metals, bismuth, mercury, methyl bromide
• Severe appearance of the tremor
• Tremor suggestive of a psychogenic origin
• Abnormal or non-existent brain MRI if family case

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: child essential tremor; electromyogram with accelerometer	Other: electromyographic essential tremor; Making a recording electromyographic recording of the essential tremors in each child included at prospective.; Collect an electromyographic recording of essential tremors already made in each child included at retrospective.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
characteristics of TE	échelle Fahn-Marin- Tolosa FMT	1 day

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
determine the electrophysiological characteristics impact of TE functional questionnaire, an electromyogram with accelerometer.	electromyogram with accelerometer	1 day

Collaborators and Investigators

• Sponsor: University Hospital, Montpellier
• Investigators: Principal Investigator: Agathe ROUBERTIE, Pr, University Hospital, Montpellier

Study record dates

Study Major Dates

• Study Start (Actual): July 1, 2018
• Primary Completion (Actual): July 2, 2021
• Study Completion (Actual): July 2, 2021

Study Registration Dates

• First Submitted: February 1, 2018
• First Submitted That Met QC Criteria: March 27, 2018
• First Posted (Actual): April 4, 2018

Study Record Updates

• Last Update Posted (Actual): November 18, 2021
• Last Update Submitted That Met QC Criteria: November 10, 2021
• Last Verified: September 1, 2021

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Central Nervous System Diseases; Nervous System Diseases; Neurologic Manifestations; Movement Disorders; Dyskinesias; Tremor; Essential Tremor
• Other Study ID Numbers: UF9770

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No