- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05956223
The Development of a System for Measurement of Tremor
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
This study aims to develop a way of objectively measuring the neurological disorders, Essential Tremor (ET) and Dystonia. These conditions can affect the upper and lower limbs, head, voice, face and trunk. ET and dystonia can be difficult to assess and treat, particularly if severe, and therapies are limited. Currently the severity of these conditions is formally assessed by clinician rated scales such as the Essential Tremor Rating Assessment Scale (TETRAS) which is biased towards the upper limbs, requires training and is not objective. There is a need for a more precise, less variable measure of tremor that can used easily be non-expert clinicians. This study questions whether it is possible to quantify ET and dystonia using a measurement system in a virtual reality (VR) environment.
We will collect data from measurement sensors embedded in the VR environment from control, ET and dystonic participants by placing them in a VR environment and instructing them to perform the TETRAS. This will help us to develop an algorithm which can measure ET severity using machine learning. We expect that the algorithm will provide a better assessment of ET and dystonia than the TETRAS.
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Sarah Osborn
- Phone Number: +61428051052
- Email: sarah.osborn@unimelb.edu.au
Study Locations
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Victoria
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East Melbourne, Victoria, Australia, 3002
- The Royal Victorian Eye and Ear Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria - Control participants
- Aged 18 to 80 years
- Able to provide informed consent for self
- Able to comply with all study procedures
Exclusion Criteria -Control participants
- Any neurological disorder
- Any other non-neurological cause of tremor e.g. medication induced
Inclusion Criteria - ET participants
- Aged 18 to 80 years
- Able to provide informed consent for self
- Clinical diagnosis of ET or ET plus syndrome
- Able to comply with all study procedures
Exclusion Criteria - ET Participants
- Tremor other than ET (e.g. parkinsonian, functional tremor)
- Presence of other movement disorder
- For DBS participants: willingness to turn off their IDU (deep brain stimulator battery) temporarily switched off during their assessment. Participants must have their own ability to turn this back on following the assessment.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: Non-Randomized
- Interventional Model: Sequential Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: Stage 1 Controls
Control participants - healthy volunteers without a known neurological disorder
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Experimental: Stage 2 Patients with Essential Tremor
Participants with moderately severe essential tremor
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Experimental: Stage 3 Patients with Essential Tremor of varying severities
Participants with essential tremor ranging from just detectable by neurologist to severe.
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Experimental: Stage 5
Participants with essential tremor and dystonia of the upper limbs, head and neck
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|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
TETRAS scores
Time Frame: up to 4 weeks
|
The TETRAS has 16 tasks each rated from 1 to 4 with 64 maximum points, with a score of 1 denoting a minimal or barely noticeable tremor and 4 denoting a severe tremor.
Scoring for the head provides 8 points; the voice and lower limbs 4 points each; and the upper limb each obtains 20 points, with an extra 4 points for handwriting and 4 for postural tremor.
|
up to 4 weeks
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Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: David R Szmulewicz, The Royal Victorian Eye and Ear Hospital
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 23-1562H
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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