- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03645239
Post-operative Emesis and Pain Outcomes After Cesarean Delivery (EPOC)
Post-operative Emesis and Pain Outcomes After Cesarean Delivery (EPOC)
Study Overview
Status
Detailed Description
Previous studies demonstrated that pain scores upon local anesthetic injection is positively correlated to post-cesarean pain scores. Anxiety, anticipated post-operative pain score and anticipated medication need are also found to be promising risk factors to post-cesarean pain management.
The investigators would investigate the risk factors of causing post-cesarean emesis, and to reaffirm that there is a positive correlation between pain on local anesthetic injection, presence of mechanical temporal summation (MTS) and post-Cesarean pain scores. 470 parturients undergoing cesarean delivery and requiring regional anaesthesia will be recruited. Pain and anxiety assessment will be conducted via visual analogue scoring (VAS), MTS assessment and a series of questionnaires. After delivery, patients will be given appropriate analgesia, and pain score at movement will be recorded. Secondary outcomes include pain scores at rest, analgesia consumption, time-to-first-rescue analgesia, opioid-related side effects, patient satisfaction and postpartum depression. A separate 125 patients will be recruited to evaluate the feasibility and patient acceptability of the use of Headspace, a mindfulness mobile application during the pre- and postnatal period to improve the maternal outcomes (emesis, pain, anxiety, depression).
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: Ban Leong Sng, FANZCA
- Phone Number: +6563941081
- Email: sng.ban.leong@singhealth.com.sg
Study Locations
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-
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Singapore, Singapore, 229899
- KK Women's and Children's Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Pregnant and going to have caesarean delivery (36 weeks gestation or more; nulliparous and multiparous);
- Healthy or have mild medical problems that are well-controlled (American Society of Anesthesiologists physical status 1-2).
Exclusion Criteria:
- History of intravenous drug or opioid abuse;
- Previous history of chronic pain syndrome;
- Emergency cesarean section;
- Undergo general anaesthesia during cesarean delivery;
- Non-English speaking.
Study Plan
How is the study designed?
Design Details
- Observational Models: Case-Control
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Control
Questionnaires, Mechanical Temporal Summation assessment and preoperative pain assessment will be assigned to patient.
Patients will be assigned to this group when they have a pain score of less than 3 (out of 10) at 6-10 post-delivery online/phone survey.
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A 180 gram von Frey filament is applied on the subject's forearm.
Patient will then be asked to rate the pinprick pain score on a verbal rating scale, 0-100.
Following this, 10 consecutive touches at random locations are applied with a 1 second interstimulus interval and within a 1 cm diameter circle.
The patient will then be asked to rate the 10th pain score (0-100).
The Mechanical Temporal Summation Score is obtained by the difference between the 11th pain score and the 1st pain score.
If the score is greater than zero, the patient is implied to have presence of Mechanical Temporal Summation.
Other Names:
Patients will be asked to rate, using a 0-10mm visual analog scale (VAS), their surgical anxiety level ("On a scale of 0-100, with 0 being not anxious at all to 100 being extremely anxious, how anxious are you about your upcoming surgery?"), their anticipated pain (On a scale of 0-10, with 0 being no pain at all and 10 being pain as bad as you can imagine, how much pain do you anticipate experiencing after your upcoming surgery?"), and using a categorical scale, their anticipated pain medication need ("On a scale of 0 to 5, with 0 being none at all, 1 being much less than average, 2 being less than average, 3 being average, 4 being more than average, and 5 being much more than average, how much pain medication do you anticipate needing after your upcoming surgery?").
Questionnaires including Hospital Anxiety and Depression Scale (HADS), EQ-5D-3L, Edinburgh Postnatal Depression Scale (EPDS), Pain Catastrophizing Scale (PCS), Central Sensitisation Inventory (CSI), pain survey and breastfeeding questionnaire will be administered to the patient.
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Postoperative pain
Questionnaires, Mechanical Temporal Summation assessment and preoperative pain assessment will be assigned to patient.
Patients will be assigned to this group when they have a pain score of equal or more than 3 (out of 10) at 6-10 post-delivery online/phone survey.
|
A 180 gram von Frey filament is applied on the subject's forearm.
Patient will then be asked to rate the pinprick pain score on a verbal rating scale, 0-100.
Following this, 10 consecutive touches at random locations are applied with a 1 second interstimulus interval and within a 1 cm diameter circle.
The patient will then be asked to rate the 10th pain score (0-100).
The Mechanical Temporal Summation Score is obtained by the difference between the 11th pain score and the 1st pain score.
If the score is greater than zero, the patient is implied to have presence of Mechanical Temporal Summation.
Other Names:
Patients will be asked to rate, using a 0-10mm visual analog scale (VAS), their surgical anxiety level ("On a scale of 0-100, with 0 being not anxious at all to 100 being extremely anxious, how anxious are you about your upcoming surgery?"), their anticipated pain (On a scale of 0-10, with 0 being no pain at all and 10 being pain as bad as you can imagine, how much pain do you anticipate experiencing after your upcoming surgery?"), and using a categorical scale, their anticipated pain medication need ("On a scale of 0 to 5, with 0 being none at all, 1 being much less than average, 2 being less than average, 3 being average, 4 being more than average, and 5 being much more than average, how much pain medication do you anticipate needing after your upcoming surgery?").
Questionnaires including Hospital Anxiety and Depression Scale (HADS), EQ-5D-3L, Edinburgh Postnatal Depression Scale (EPDS), Pain Catastrophizing Scale (PCS), Central Sensitisation Inventory (CSI), pain survey and breastfeeding questionnaire will be administered to the patient.
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Control (non-Headspace)
Questionnaires, Mechanical Temporal Summation assessment and preoperative pain assessment will be assigned to patient.
Twenty five patients will be assigned to this group when they agree to participate in a sub-study on the use of a mindfulness exercise mobile app (Headspace).
Patients will have a follow-up online/phone call survey at day 7-20 and 4-8 weeks after delivery.
|
A 180 gram von Frey filament is applied on the subject's forearm.
Patient will then be asked to rate the pinprick pain score on a verbal rating scale, 0-100.
Following this, 10 consecutive touches at random locations are applied with a 1 second interstimulus interval and within a 1 cm diameter circle.
The patient will then be asked to rate the 10th pain score (0-100).
The Mechanical Temporal Summation Score is obtained by the difference between the 11th pain score and the 1st pain score.
If the score is greater than zero, the patient is implied to have presence of Mechanical Temporal Summation.
Other Names:
Patients will be asked to rate, using a 0-10mm visual analog scale (VAS), their surgical anxiety level ("On a scale of 0-100, with 0 being not anxious at all to 100 being extremely anxious, how anxious are you about your upcoming surgery?"), their anticipated pain (On a scale of 0-10, with 0 being no pain at all and 10 being pain as bad as you can imagine, how much pain do you anticipate experiencing after your upcoming surgery?"), and using a categorical scale, their anticipated pain medication need ("On a scale of 0 to 5, with 0 being none at all, 1 being much less than average, 2 being less than average, 3 being average, 4 being more than average, and 5 being much more than average, how much pain medication do you anticipate needing after your upcoming surgery?").
Questionnaires including Hospital Anxiety and Depression Scale (HADS), EQ-5D-3L, Edinburgh Postnatal Depression Scale (EPDS), Pain Catastrophizing Scale (PCS), Central Sensitisation Inventory (CSI), pain survey and breastfeeding questionnaire will be administered to the patient.
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Experimental (Headspace)
Questionnaires, Mechanical Temporal Summation assessment and preoperative pain assessment will be assigned to patient.
Fifty five patients will be assigned to this group when they agree to participate in a sub-study on the use of a mindfulness exercise mobile app (Headspace).
Patients will have a follow-up online/phone call survey at day 7-20 and 4-8 weeks after delivery.
|
A 180 gram von Frey filament is applied on the subject's forearm.
Patient will then be asked to rate the pinprick pain score on a verbal rating scale, 0-100.
Following this, 10 consecutive touches at random locations are applied with a 1 second interstimulus interval and within a 1 cm diameter circle.
The patient will then be asked to rate the 10th pain score (0-100).
The Mechanical Temporal Summation Score is obtained by the difference between the 11th pain score and the 1st pain score.
If the score is greater than zero, the patient is implied to have presence of Mechanical Temporal Summation.
Other Names:
Patients will be asked to rate, using a 0-10mm visual analog scale (VAS), their surgical anxiety level ("On a scale of 0-100, with 0 being not anxious at all to 100 being extremely anxious, how anxious are you about your upcoming surgery?"), their anticipated pain (On a scale of 0-10, with 0 being no pain at all and 10 being pain as bad as you can imagine, how much pain do you anticipate experiencing after your upcoming surgery?"), and using a categorical scale, their anticipated pain medication need ("On a scale of 0 to 5, with 0 being none at all, 1 being much less than average, 2 being less than average, 3 being average, 4 being more than average, and 5 being much more than average, how much pain medication do you anticipate needing after your upcoming surgery?").
Questionnaires including Hospital Anxiety and Depression Scale (HADS), EQ-5D-3L, Edinburgh Postnatal Depression Scale (EPDS), Pain Catastrophizing Scale (PCS), Central Sensitisation Inventory (CSI), pain survey and breastfeeding questionnaire will be administered to the patient.
The mindfulness exercise mobile application, Headspace, will be downloaded into the patients' mobile devices.
Patients will be asked to experience a mindfulness exercise for 10-30 minutes before delivery.
HADS and pain score will be asked after the intervention.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Postsurgical pain scores in both groups: Numeric Rating Scale
Time Frame: 6 -10 weeks after delivery
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Pain scores (Numeric Rating Scale 0-10) at 6-10 weeks follow-up evaluations.
Zero being no pain, and 10 being the worst pain possible.
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6 -10 weeks after delivery
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Pain vulnerability in both groups: Pain Catastrophizing Scale
Time Frame: 7 weeks (Upon recruitment until 5-14 days after delivery)
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Assessment will be done via Pain Catastrophizing Scale (PCS) questionnaire before surgery.
Pain catastrophizing refers to the negative thought processes patients have when they are exposed to pain or painful experiences.
The PCS is a 13-item scale, with each item rated on a 5-point scale: 0 (Not at all) to 4 (all the time).
It is broken into three subscales being magnification (0-12), rumination (0-16), and helplessness (0-24).
A higher value in each subscale indicates a higher tendency to that subscale (worse outcome).
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7 weeks (Upon recruitment until 5-14 days after delivery)
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Mechanical Temporal Summation as measured by von Frey filament in both groups
Time Frame: 1 day (10 minutes)
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Assessment will be done via Mechanical Temporal Summation assessment before surgery.
A 180 gram von Frey filament is applied on the subject's forearm.
Patient will then be asked to rate the pinprick pain score on a verbal rating scale, 0-100.
Following this, 10 consecutive touches at random locations are applied with a 1 second interstimulus interval and within a 1 cm diameter circle.
The patient will then be asked to rate the 10th pain score (0-100).
The Mechanical Temporal Summation Score is obtained by the difference between the 11th pain score and the 1st pain score.
If the score is greater than zero, the patient is implied to have presence of Mechanical Temporal Summation.
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1 day (10 minutes)
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Edinburgh Postnatal Depression Scale (EPDS) before and after delivery
Time Frame: 6 -10 weeks after delivery
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Edinburgh Postnatal Depression Scale (EPDS) is a 10-item self reporting scale to evaluate the postnatal depression.
Participants are asked to respond according to how they have felt in the past seven days.
Each item is measured on a 4-point scale (0-3), with a total score in the range of 0 to 30.
A higher total score indicates a greater degree of depressive symptoms.
A score of 10 and above indicates clinically significant depressive symptoms.
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6 -10 weeks after delivery
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Collaborators and Investigators
Investigators
- Principal Investigator: Farida Ithnin, MB BCh BAO, KK Women's and Children's Hospital
Publications and helpful links
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- ANAESPRG18/02
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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